Results 51 to 60 of about 4,122,734 (351)

EAACI Biologicals Guidelines—Recommendations for severe asthma

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care pathways and differences between national or regional healthcare systems ...
I. Agache, C. Akdis, M. Akdiş, G. Canonica, T. Casale, T. Chivato, J. Corren, D. Chu, S. D. Del Giacco, T. Eiwegger, B. Flood, D. Firinu, J. Gern, E. Hamelmann, N. Hanania, I. Hernández-Martín, R. Knibb, M. Mäkelä, Parameswaran Nair, L. O' Mahony, N. Papadopoulos, A. Papi, Hae‐Sim Park, L. A. Pérez de Llano, O. Pfaar, S. Quirce, J. Sastre, M. Shamji, J. Schwarze, Ó. Palomares, M. Jutel   +30 more
semanticscholar   +1 more source

Severe Asthma Toolkit: an online resource for multidisciplinary health professionals—needs assessment, development process and user analytics with survey feedback

BMJ Open, 2020
Objectives Severe asthma imposes a significant burden on individuals, families and the healthcare system. New treatment and management approaches are emerging as effective options for severe asthma.
Peter G Gibson, Vanessa M McDonald, Peter A B Wark, John W Upham, Bruce Thompson, Mark Hew, Guy B Marks, Steven Maltby, Helen K Reddel, Gregory G King, Vanessa L Clark, Louisa Owens, Stephen Oo, Alan L James   +13 more
doaj   +1 more source

Biological therapy for severe asthma

Asthma Research and Practice, 2021
Around 5–10% of the total asthmatic population suffer from severe or uncontrolled asthma, which is associated with increased mortality and hospitalization, increased health care burden and worse quality of life. In the last few years, new drugs have been
S. Dragonieri, G. E. Carpagnano
semanticscholar   +1 more source

The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma [PDF]

The Korean Journal of Internal Medicine, 2022
Severe asthma constitutes a serious health burden with significant morbidity and socioeconomic costs. The development and introduction of new biologics targeting type 2 inflammation changed the paradigm for management of severe asthma and initiated a ...
Sang-Heon Kim, Hyun Lee, So-Young Park, So Young Park, Woo-Jung Song, Joo-Hee Kim, Heung-Woo Park, You Sook Cho, Ho Joo Yoon, on behalf of the KoSAR investigators   +9 more
doaj   +1 more source

Mepolizumab effectiveness and identification of super-responders in severe asthma

European Respiratory Journal, 2020
Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from randomised controlled trials are applicable in a broader population.
E. Harvey, D. Langton, C. Katelaris, S. Stevens, C. Farah, A. Gillman, J. Harrington, M. Hew, V. Kritikos, N. Radhakrishna, P. Bardin, M. Peters, P. Reynolds, J. Upham, M. Baraket, S. Bowler, J. Bowden, Jimmy Chien, L. Chung, C. Grainge, C. Jenkins, G. Katsoulotos, Joy Lee, V. McDonald, H. Reddel, J. Rimmer, P. Wark, P. Gibson   +27 more
semanticscholar   +1 more source

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source

Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India

Respirology Case Reports, 2021
Severe asthma can be associated with eosinophilic or allergic phenotypes or both. Eosinophilic inflammation is associated with exacerbations and disease severity due to biological activity of interleukin‐5 (IL‐5).
Venkata Nagarjuna Maturu, Priti Meshram, Soumya Das, Ashok Kumar Rajput, Arun Chowdary Kotaru, Bhavesh Kotak, Neeraj Markandeywar, Simran Chhatwal   +7 more
doaj   +1 more source

Increasing prevalence of asthma diagnosis and symptoms in children is confined to mild symptoms [PDF]

, 2001
BACKGROUND: The prevalence of childhood asthma is increasing but few studies have investigated trends in asthma severity. We investigated trends in asthma diagnosis and symptom morbidity between an eight year time period in a paired prevalence study.
Billings, C., Das, C., Duggan, R., Ng Man Kwong, G., Powell, C.V.E., Primhak, R.A., Proctor, A., Whyte, M.K.B.   +7 more
core   +2 more sources

Biologics in severe asthma: a state-of-the-art review

European Respiratory Review
Asthma is considered severe if it remains uncontrolled despite optimal conventional therapy, characterised by poor symptom control, frequent exacerbations and increased exposure to systemic corticosteroids.
Bishal Gyawali, Steve N. Georas, Sandhya Khurana   +2 more
semanticscholar   +1 more source

Clinical characteristics of complete responders versus non-complete responders to omalizumab, benralizumab and mepolizumab in patients with severe asthma: a long-term retrospective analysis

Annals of Medicine
Background Some patients with severe asthma may benefit from treatment with biologics, but evidence has been mostly collected from randomized controlled trials (RCTs), in which patients’ characteristics are different from those encountered in asthma ...
Maria Basagaña, Carlos Martínez-Rivera, Clara Padró, Ignasi Garcia-Olivé, Mimar Martínez-Colls, Juan Navarro, Laura Pardo, Paula Cruz, Gloria Cardona Peitx, Lídia Carabias, Albert Roger, Jorge Abad, Antoni Rosell   +12 more
doaj   +1 more source