Results 71 to 80 of about 312,536 (265)

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Determinants of Asthma Severity [PDF]

International Archives of Allergy and Immunology, 2009
Djukanović, Ratko, Howarth, Peter, Vrugt, Bart, Wilson, Susan, Semper, Amanda, Bradding, Peter, Aalbers, Rene, Holgate, Stephen   +7 more
openaire   +4 more sources

Burden of asthma exacerbations and health care utilization in pediatric patients with asthma in the US and England

Immunity, Inflammation and Disease, 2020
Background Data on asthma burden in pediatric patients are limited; this real‐world study investigated exacerbation frequency and health care resource utilization (HCRU) in pediatric asthma patients from the US and England.
Mugdha Gokhale, Takako Hattori, Lee Evitt, Warren Lenney, Beth Nordstrom, Jenna Collins, Anna Schultze, Melissa K. Van Dyke   +7 more
doaj   +1 more source

Female‐Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital‐Based Cohort Study From the Taiwan Precision Medicine Initiative

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Bitter taste receptors (T2Rs) function in the innate immune defense of the sinonasal mucosa; however, the genetic association between the TAS2R gene family and chronic rhinosinusitis (CRS) remains understudied in Asian populations.
Rong‐San Jiang, Man‐Wei Hua, I‐Chieh Chen, Yi‐Ming Chen, Shun‐Hung Lin, Kuan‐Yu Lai, Yi‐Chen Chen   +6 more
wiley   +1 more source

Oral corticosteroid-sparing effects of reslizumab in the treatment of eosinophilic granulomatosis with polyangiitis

ERJ Open Research, 2020
Brian D. Kent, Grainne d'Ancona, Mariana Fernandes, Linda Green, Cris Roxas, Louise Thomson, Alexandra M. Nanzer, Joanne Kavanagh, Sangita Agarwal, David J. Jackson   +9 more
doaj   +1 more source

Understanding disease burden, challenges in current treatment strategies and call for action for management of severe asthma in Asia: a position statement from Asian respiratory experts

Frontiers in Allergy
In the Asia-Pacific region, there is limited data on the full extent of the burden of severe asthma, as well as a lack of clear guidance on improving care standards.
Mariko Siyue Koh, Mariko Siyue Koh, Ken Ka Pang Chan, Ken Ka Pang Chan, Koichi Fukunaga, Sang-Heon Kim, Le Thi Tuyet Lan, Azza Omar, Thitiwat Sriprasart, Deepak Talwar, Min Zhang, Shih-Lung Cheng, Shih-Lung Cheng   +12 more
doaj   +1 more source

Assessing Surgical Extent in Endoscopic Sinus Surgery: A Scoping Review of Scoring Systems

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Endoscopic sinus surgery (ESS) varies substantially in the extent of surgical dissection performed, even when described under the same procedural label. In chronic rhinosinusitis, this heterogeneity may influence postoperative outcomes, revision rates, and response to biologic therapies.
Alexander Lein, Marie T. Ehrgott, Linda Liu, Archana Jaiswal, Rajiv K. Bhalla, Noel Ayoub, Faris F. Brkic, David T. Liu   +7 more
wiley   +1 more source

Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis

ERJ Open Research, 2020
Alexandra M. Nanzer, Jaideep Dhariwal, Joanne Kavanagh, Andrew Hearn, Mariana Fernandes, Louise Thomson, Cris Roxas, Linda Green, Grainne D'Ancona, Sangita Agarwal, Brian D. Kent, David J. Jackson   +11 more
doaj   +1 more source

Severe asthma in Japan

Allergology International, 2019
The characteristic phenotype of severe asthma in Japan seems to be distilled into the following two features: low incidence of obesity and high prevalence of patients with type 2 inflammation. Only 5-7% of Japanese severe asthma patients had a body mass index (BMI) ≥30 kg/m2, and more than 80% of patients with severe asthma exhibited type 2 ...
openaire   +3 more sources

Mepolizumab and COPD in Real Life

Open Respiratory Archives, 2022
Fernando Revuelta-Salgado, Rocío Magdalena Díaz-Campos, Ascensión Hernando-Sanz, Carlos Melero-Moreno   +3 more
doaj   +1 more source