Results 91 to 100 of about 2,200,340 (304)

The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project

Journal of Allergy and Clinical Immunology: Global
Background: Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. Objective: We sought to determine the burden (prevalence, mortality, and activity and work impairment) of severe ...
Bruce J. Kirenga, MBChB, MMed, PhD, Jeremiah Chakaya, MBChB, MMed, Getnet Yimer, MD, PhD, George Nyale, MBChB, MMed, Tewodros Haile, MD, Winters Muttamba, MBChB, MPH, Levicatus Mugenyi, PhD, Winceslaus Katagira, MBChB, MMed, William Worodria, MBChB, MMed, PhD, Hellen Aanyu-Tukamuhebwa, MBChB, MMed, Njira Lugogo, MD, Moses Joloba, MBChB, MS, PhD, Tesfaye B. Mersha, PhD, Amsalu Bekele, MD, Fred Makumbi, PhD, Amha Mekasha, PhD, Cynthia L. Green, PhD, Corina de Jong, PhD, Moses Kamya, MBChB, MMed, MPH, PhD, Thys van der Molen, MD, PhD   +19 more
doaj   +1 more source

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

World Allergy Organization Journal, 2017
There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra- to extra-cellular mediators to the whole organ structure und functioning of the lung.
Iris Koper, Karin Hufnagl, Rainer Ehmann
doaj   +1 more source

Severe Asthma Questionnaire (SAQ) and Asthma Control Questionnaire (ACQ) as Early Predictors of Biologic Response in Severe Asthma [PDF]

Drew Davies,1 Joseph W Lanario,2,3 Michael E Hyland,2 Matthew Masoli1,3 1Department of Respiratory Medicine, Royal Devon and Exeter Hospital, University of Exeter, Exeter, UK; 2Faculty of Health, University of Plymouth, Plymouth, UK; 3University of ...
Lanario JW, Masoli M, Hyland ME, Davies D   +3 more
core  

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

Asthma Is More Severe in Older Adults.

PLoS ONE, 2015
BackgroundSevere asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration.MethodsThis is a cross-sectional study of prospectively
Joe G Zein, Raed A Dweik, Suzy A Comhair, Eugene R Bleecker, Wendy C Moore, Stephen P Peters, William W Busse, Nizar N Jarjour, William J Calhoun, Mario Castro, K Fan Chung, Anne Fitzpatrick, Elliot Israel, W Gerald Teague, Sally E Wenzel, Thomas E Love, Benjamin M Gaston, Serpil C Erzurum, Severe Asthma Research Program   +18 more
doaj   +1 more source

Efficacy of azithromycin in severe asthma from the AMAZES randomised trial

ERJ Open Research, 2019
Background Low-dose azithromycin is an effective therapy for persistent asthma; however, its benefit in severe asthma is not defined. Methods Participants with severe asthma were identified from the AMAZES randomised, placebo-controlled trial of long ...
Peter G. Gibson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guy B. Marks, Melissa Baraket, Heather Powell, Jodie L. Simpson   +11 more
doaj   +1 more source

Rhinosinusitis Predispose Asthmatic Patients to Severe Bronchial Asthma [PDF]

In this study, we evaluated the relationship between rhinosinusitis to the severity of asthma in asthmatic patients. This cross-sectional study was conducted on 90 patients with asthma referring to Imam Khomeini Hospital in Ardabil city.
غفرانی, محسن, اناری, حسن, اعظمی, احد, حبیب زاده, الهام, شرقی, افشان   +4 more
core   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Editorial : experimental models of asthma [PDF]

, 2008
Since 2002, a workshop entitled “Asthma in animal models” has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in collaboration with the collaborative research centre ...
Thomas Tschernig, David A Groneberg, Tschernig, Thomas, Braun, Armin, Groneberg, Jan David Alexander, Armin Braun, Groneberg, D.A., Braun, A., Tschernig, T.   +8 more
core   +1 more source

The Mixed Neutrophilic–Eosinophilic Endotype of CRSwNP Blunts Postsurgical Improvement as Determined by the Completeness of Surgery Index

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The Completeness of Surgery Index (CoSI) is a novel metric for assessing surgical quality in chronic rhinosinusitis with nasal polyps (CRSwNP). Structured histopathology (SHP) is helpful for characterizing drivers of inflammation. Integrating these two tools to identify patients at higher risk for surgically recalcitrant disease has
Vidit M. Talati, Kerol Faltas, Michael R. Xiang, Randy Bach, Spencer L. Yueh, Margaret B. Mitchell, Alan D. Workman, Michael A. Kohanski, Nithin D. Adappa, Jennifer E. Douglas, Noam A. Cohen, John V. Bosso, James N. Palmer   +12 more
wiley   +1 more source