Results 101 to 110 of about 2,200,340 (304)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Determinants of Asthma Severity [PDF]

International Archives of Allergy and Immunology, 2009
Djukanović, Ratko, Howarth, Peter, Vrugt, Bart, Wilson, Susan, Semper, Amanda, Bradding, Peter, Aalbers, Rene, Holgate, Stephen   +7 more
openaire   +4 more sources

Assessing severe asthma [PDF]

European Respiratory Journal, 2016
Structured assessment of patients identifies asthma misdiagnosis, and improves asthma control and quality of life http://ow.ly ...
openaire   +2 more sources

Differences between patients who achieved asthma control and those who remain uncontrolled after standardized severe asthma care strategy

, 2020
Objective: To assess clinical, functional, and inflammatory patterns of children and adolescents with severe uncontrolled asthma, and investigate the differences between patients who achieved asthma control and those who remain uncontrolled after ...
Morcillo, André Moreno, Mazzola, Taís Nitsch, Hashimoto, Simone, Matsunaga, Natasha Yumi, Toro, Adyleia Aparecida Dalbo Contrera, Gianfrancesco, Lívea, Oliveira, Marina Simões, Ribeiro, Maria Ângela Gonçalves Oliveira, Ribeiro, José Dirceu, Adyleia Aparecida Dalbo Contrera Toro, Lívea Gianfrancesco, Maria Ângela Gonçalves Oliveira Ribeiro, André Moreno Morcillo, José Dirceu Ribeiro, Simone Hashimoto, Natasha Yumi Matsunaga, Taís Nitsch Mazzola, Marina Simões Oliveira   +17 more
core   +1 more source

Oral corticosteroid-sparing effects of reslizumab in the treatment of eosinophilic granulomatosis with polyangiitis

ERJ Open Research, 2020
Brian D. Kent, Grainne d'Ancona, Mariana Fernandes, Linda Green, Cris Roxas, Louise Thomson, Alexandra M. Nanzer, Joanne Kavanagh, Sangita Agarwal, David J. Jackson   +9 more
doaj   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis

ERJ Open Research, 2020
Alexandra M. Nanzer, Jaideep Dhariwal, Joanne Kavanagh, Andrew Hearn, Mariana Fernandes, Louise Thomson, Cris Roxas, Linda Green, Grainne D'Ancona, Sangita Agarwal, Brian D. Kent, David J. Jackson   +11 more
doaj   +1 more source

Understanding disease burden, challenges in current treatment strategies and call for action for management of severe asthma in Asia: a position statement from Asian respiratory experts

Frontiers in Allergy
In the Asia-Pacific region, there is limited data on the full extent of the burden of severe asthma, as well as a lack of clear guidance on improving care standards.
Mariko Siyue Koh, Mariko Siyue Koh, Ken Ka Pang Chan, Ken Ka Pang Chan, Koichi Fukunaga, Sang-Heon Kim, Le Thi Tuyet Lan, Azza Omar, Thitiwat Sriprasart, Deepak Talwar, Min Zhang, Shih-Lung Cheng, Shih-Lung Cheng   +12 more
doaj   +1 more source

Factors Associated With the Control of Severe Asthma

, 2010
Introduction: Control is a priority treatment objective in asthma, and classification based on control is recommended in the follow-up of asthmatic patients. Different factors affect this control, and there are several regional differences, both in terms
Rodríguez Hermosa, Juan Luis, Barcina Sánchez, Carlos, Muñoz Mínguez, Mercedes, Calle Rubio, Myrian, Álvarez-Sala Walther, José Luis, Myriam Calle Rubio, Jose Luis Alvarez-Sala Walther, Mercedes Muñoz Mínguez, Juan Luis Rodriguez Hermosa, Carlos Barcina Sánchez   +9 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source