Results 61 to 70 of about 2,200,340 (304)

Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort

ERJ Open Research, 2023
Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns of severe asthma at ...
Susanne Hansen, Anna von Bülow, Patrik Sandin, Olivia Ernstsson, Christer Janson, Lauri Lehtimäki, Hannu Kankaanranta, Charlotte Ulrik, Bernt Bøgvald Aarli, Hanna Fues Wahl, Kirk Geale, Sheila Tuyet Tang, Maija Wolf, Tom Larsen, Alan Altraja, Helena Backman, Maritta Kilpeläinen, Arja Viinanen, Dora Ludviksdottir, Paula Kauppi, Asger Sverrild, Sverre Lehmann, Vibeke Backer, Valentyna Yasinska, Tina Skjold, Jussi Karjalainen, Apostolos Bossios, Celeste Porsbjerg   +27 more
doaj   +1 more source

Managing the pediatric patient with refractory asthma: a multidisciplinary approach [PDF]

, 2017
Children with asthma that is refractory to high levels of prescribed treatment are described as having problematic severe asthma. Those in whom persistent symptoms result from a failure of basic asthma management are described as having “difficult asthma”
Winch, D, Bush, A, Housley, G, Valentina Fainardi, Beresford, F, Angela Jamalzadeh, Sejal Saglani, Hall, P, Fainardi, V, Saglani, S, David Winch, Michelle Nightingale, Fran Beresford, Andrew Bush, Cook, J, Louise Fleming, Fleming, L, James Cook, Jamalzadeh, A, Nightingale, M, Pippa Hall, Georgie Housley, Winch D., Beresford F., Fleming L., Bush A., Cook J., Nightingale M., Fainardi V., Saglani S., Hall P., Housley G., Jamalzadeh A.   +32 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Severe asthma and acute attacks: diagnosis and management in adults and children

South African Family Practice, 2007
Patients who continue to have symptoms with frequent attacks of asthma despite being adherent to treatment with multiple asthma medications, have severe asthma.
S. Kling
doaj   +1 more source

SEVERE ASTHMA IS REALLY UNCOMMON [PDF]

, 2012
We describe the case of a 10-year-old girl with a history of severe persistent asthma and exercise-induced-asthma, controlled using an appropriate treatment with inhaled corticosteroid-long-acting beta-2 adrenergic agonists (ICS+LABA) and leukotriene ...
Ilaria Ernesti, Valentina De Vittori, Valeria Lollobrigida, Camilla Celani, CELANI, CAMILLA, LOLLOBRIGIDA, VALERIA, Anna Maria Zicari, CESONI, AZZURRA, DUSE, MARZIA, Marzia Duse, DE VITTORI, VALENTINA, Renato Cutrera, ZICARI, Anna Maria, Azzurra Cesoni Marcelli   +13 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

People with moderate to severe asthma [PDF]

Updated Sept. 11, 2020This information is based on what we currently know about the spread and severity of coronavirus disease 2019 (COVID-19).Risk of Severe Illness from COVID-19 -- Treatment -- Prepare for COVID-19 -- Follow your Asthma Action Plan ...

core   +6 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Allergy in severe asthma

Allergy, 2016
It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from ...
DEL GIACCO, STEFANO, Bakirtas, Arzu, Bel, Elizabeth, Custovic, Adnan, Diamant, Zuzana, Hamelmann, Eckard, Heffler, Enrico, Kalayci, Ömer, Saglani, Sejal, Sergejeva, Svetlana, Seys, Sven, Simpson, Angela, Bjermer, Leif   +12 more
openaire   +9 more sources