Results 61 to 70 of about 4,122,734 (351)

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

European Respiratory Journal, 2019
This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the European Respiratory Society/American ...
F. Holguin, J. Cardet, K. Chung, S. Diver, D. S. Ferreira, A. Fitzpatrick, M. Gaga, L. Kellermeyer, S. Khurana, Shandra L. Knight, V. McDonald, R. Morgan, V. Ortega, D. Rigau, P. Subbarao, T. Tonia, I. Adcock, E. Bleecker, C. Brightling, L. Boulet, M. Cabana, M. Castro, P. Chanez, A. Custovic, R. Djukanović, U. Frey, B. Frankemölle, P. Gibson, D. Hamerlijnck, N. Jarjour, S. Konno, Huahao Shen, C. Vitary, A. Bush   +33 more
semanticscholar   +1 more source

Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era

Thorax, 2020
Background The UK Severe Asthma Registry (UKSAR) is the world’s largest national severe asthma registry collecting standardised data on referrals to UK specialist services.
D. Jackson, J. Busby, P. Pfeffer, A. Menzies-Gow, T. Brown, R. Gore, M. Doherty, A. Mansur, S. Message, R. Niven, M. Patel, L. Heaney   +11 more
semanticscholar   +1 more source

Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]

, 2012
Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose, Markus A., Schubert, Ralf, Schulze, Johannes, Voss, Sandra, Zielen, Stefan, Zissler, Ulrich   +5 more
core   +2 more sources

Recent Advances in Severe Asthma: from Phenotypes to Personalized Medicine.

Chest, 2020
This review focuses on recent clinical and translational discoveries in severe and uncontrolled asthma that now enable phenotyping and personalized therapies in these patients.
Nathan Schoettler, M. Strek
semanticscholar   +1 more source

Asthma control in severe asthma and occupational exposures to inhalable asthmagens

BMJ Open Respiratory Research
Introduction Work-related asthma accounts for ≥25% of asthma in working-age populations, though the relationship between work exposures and symptoms is frequently missed, leading to poor health and employment outcomes.
Mamidipudi Thirumala Krishna, Adel H Mansur, Gareth I Walters, Nicole Le Moual, Christopher C Huntley, Julie Marsh, Christopher Reilly, Hanan Hussein, Ali Bahron   +8 more
doaj   +1 more source

Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study [PDF]

, 2011
Background The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes.
Taehoon Lee, null null, Yoon Su Lee, Yun-Jeong Bae, Tae-Bum Kim, Seon Ok Kim, Sang-Heon Cho, Hee-Bom Moon, You Sook Cho   +8 more
core   +1 more source

Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Five biologicals have been approved for severe eosinophilic asthma, a well‐recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to
I. Agache, Jessica Beltran, C. Akdis, M. Akdiş, C. Canelo-Aybar, W. Canonica, T. Casale, T. Chivato, J. Corren, S. D. Del Giacco, T. Eiwegger, D. Firinu, J. Gern, E. Hamelmann, N. Hanania, M. Mäkelä, I. H. Martín, Parameswaran Nair, L. O’Mahony, N. Papadopoulos, A. Papi, Hae‐Sim Park, L. A. Pérez de Llano, M. Posso, Claudio Rocha, S. Quirce, J. Sastre, M. Shamji, Yang Song, Corinna Steiner, J. Schwarze, P. Alonso-Coello, Ó. Palomares, M. Jutel   +33 more
semanticscholar   +1 more source

Detection of Rs9939609 Polymorphism of Fto Gene and Rs324011 Polymorphism of Stat6 Gene and Severity Degree of Bronchial Asthma Associated with Obesity [PDF]

, 2017
The aim of this research was to analyze the distribution of FTO and STAT6 genes polymorphism in patients with bronchial asthma (BA), associated with obesity (Ob) depending on the main disease severity degree.Materials and methods.
Fediv, A. (Alexander), Melnik, E. (Elena)   +1 more
core   +2 more sources

Clinical utility of fractional exhaled nitric oxide in severe asthma management

European Respiratory Journal, 2020
Asthma is a chronic inflammatory disease of the airways, affecting over 350 million people worldwide and placing a significant burden on healthcare providers and wider society.
A. Menzies-Gow, A. Mansur, C. Brightling
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source