Results 121 to 130 of about 136,816 (264)

The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma

Pediatric Discovery, EarlyView.
ABSTRACT Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first‐line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways.
Tangqiaochu Gan, Zhou Fu, Chao Niu
wiley   +1 more source

Histone Lactylation Enhances Th17 Cell Differentiation Through DPP4 to Promote Epithelial-Mesenchymal Transition in Asthma. [PDF]

Lung
Zhong X, Luo Y, Su J, Liang Y, Ding K, He X, Xiao B, Hou L, Xue F, Zhou G, Ling F, Gou Y, Ma L.   +12 more
europepmc   +1 more source

Evidence‐based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China

Pediatric Investigation, EarlyView.
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols. Recent years have witnessed substantial progress in clinical
Committee of Pediatrics, China Medical Education Association, Cooperative Group of Asthma, the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, Pediatric Respiratory Work Committee, Society of Pulmonologists, Chinese Medical Doctor Association, Committee of Pediatrics, Chinese Research Hospital Association, Pediatric Professional Committee of the Chinese Non‐public Medical Institutions Association, Professional Committee of Children's Health and Pharmaceutical Research, China Association of Traditional Chinese Medicine, Children's Safe Medication Branch of China News of Drug Information Association, Pediatric Expert Committee of China Primary Health Care Foundation, China International Medical Foundation   +16 more
wiley   +1 more source

Pulmonary Langerhans Cell Histiocytosis Presenting as Multiple Obstructing Bronchial Lesions and Pulmonary Masses. [PDF]

Clin Respir J
Fan J, Liu C, Yang Z, Sun D.
europepmc   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Narrative review: mucus plugging in chronic obstructive lung diseases and bronchiectasis. [PDF]

Eur Clin Respir J
Schou C, Thomander T, Hisinger-Mölkänen H, Genberg E, Mäkitalo L, Kreivi HR, Bjerrehave Nielsen L, Mazur W, Kauppi P.   +8 more
europepmc   +1 more source

[Bronchial asthma as a multifactorial disease].

Postepy higieny i medycyny doswiadczalnej, 2004
Asthma is a common condition that results from the interaction of an unknown number of genes with environmental factors. Here, we describe the recent advances in this field including results of genome-wide searches for susceptibility genes.
openaire   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Alterations to the Bronchial Gene-Expression Effects of Tobacco Smoking in People Living With HIV. [PDF]

J Acquir Immune Defic Syndr
Lee M, Olson A, Pickering RT, Ieong MH, Kivett D, Roche S, Xiao X, Liu G, Asundi A, Lin NH, Lenburg ME.   +10 more
europepmc   +1 more source

Variation on Toxic and Inflammatory Potential of Coal Smoke of Different Sources From a Region With High Lung Cancer Risk

Environmental Toxicology, EarlyView.
ABSTRACT Excess lung cancer risk in Xuanwei and Fuyuan, China, has been attributed to household air pollution from use of a locally sourced smoky (bituminous) coal. However, the carcinogenic mechanisms remain unclear. Given the important role of inflammation in lung cancer development, this study compared the proinflammatory potentials of the ...
Yongliang Zhang, Wei Hu, Nathanial Rothman, Dingyu Liu, Jihua Li, Jun Xu, Bofu Ning, Roel Vermeulen, Qing Lan, Flemming R. Cassee, George S. Downward   +10 more
wiley   +1 more source