Results 31 to 40 of about 136,816 (264)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

High probability of comorbidities in bronchial asthma in Germany

npj Primary Care Respiratory Medicine, 2017
Bronchial asthma: Prevalence of co-existing diseases in Germany Patients in Germany with bronchial asthma are highly likely to suffer from co-existing diseases and their treatments should reflect this.
S. Heck, S. Al-Shobash, D. Rapp, D. D. Le, A. Omlor, A. Bekhit, M. Flaig, B. Al-Kadah, W. Herian, R. Bals, S. Wagenpfeil, Q. T. Dinh   +11 more
doaj   +1 more source

Middle Lobe Syndrome Associated with Bronchial Anthracofibrosis

Acta Medica Lituanica, 2020
Bronchial anthracofibrosis has been defined as airway narrowing associated with dark pigmentation on bronchoscopy without an appropriate history of pneumoconiosis or smoking. We present a case of a 67-year-old, non-smoking female patient who was referred
Ugur Gonlugur, Tanseli Gonlugur, Sule Ozer   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Diagnosis of osteopenic syndrome. Osteopenic syndrome in bronchial asthma patients

Бюллетень сибирской медицины, 2006
Osteopenic syndrome in chronic obstructive pulmonary diseases including bronchial asthma represents actual and insufficiently studied area of medical science in view of ambiguous data on influence of glucocorticosteroid therapy and inflammation as basic ...
O. P. Zorkaltseva, V. D. Zavadovskaya, O. S. Kobyakova, O. Yu. Kilina, E. Sh. Nigmatova   +4 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Development and validation of a nomogram to predict atelectasis in adult lymph node fistula tracheobronchial tuberculosis patients

Frontiers in Medicine
BackgroundLymph node fistula tracheobronchial tuberculosis (TBTB) is a severe respiratory condition that can result in complications such as airway stenosis and atelectasis, posing significant clinical challenges, particularly in adults.
Quhua Yin, Guojian Ou, Yi Zhou, Xiaojian Wen, Heping Huang, Jie Ling, Li Luo   +6 more
doaj   +1 more source

The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset

Gut Microbes, 2023
Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases.
Takashi Ito, Yumiko Nakanishi, Ryohei Shibata, Noriko Sato, Toshi Jinnohara, Sayo Suzuki, Wataru Suda, Masahira Hattori, Ikuo Kimura, Taiji Nakano, Fumiya Yamaide, Naoki Shimojo, Hiroshi Ohno   +12 more
doaj   +1 more source

Efficacy of Bronchial Artery Embolization for Clinically Suspected Bronchial Dieulafoy’s Disease

Current Medical Imaging Formerly Current Medical Imaging Reviews, 2023
Background:: The efficacy of bronchial artery embolization (BAE) for bronchial Dieulafoy’s disease (BDD) has not been well established. Objective:: This study aimed to evaluate the safety and efficacy of BAE in patients with clinically suspected BDD presenting with major hemoptysis, and to describe angiographic findings. Methods:: 17 patients (all
Jung Guen Cha, Jihoon Hong, Gab Chul Kim, Byunggeon Park, Jongmin Park, Seo Young Park, Kyung Min Shin, Jae-Kwang Lim, So Mi Lee   +8 more
openaire   +2 more sources

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source