Results 21 to 30 of about 4,976 (187)

Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study

Respiratory Research, 2009
Background To evaluate the sensitivity, specificity and predictive values of fractional exhaled nitric oxide (FENO) for the diagnosis of asthma in general practice. Methods Prospective diagnostic study with 160 patients attending 10 general practices for
Laux Gunter, Gindner Lena, Schermer Tjard, Tilemann Lisa, Schneider Antonius, Szecsenyi Joachim, Meyer Franz   +6 more
doaj   +1 more source

Based on Real-world Data Analysis about Clinical Application of Bronchial Provocation Test [PDF]

Zhongguo quanke yixue
Background The bronchial provocation test (BPT) is a widely utilized method for assessing airway hyperreactivity (AHR) and serves as a crucial tool for both the diagnosis and therapeutic evaluation of asthma.
LIU Shuyi, LI Yun, YE Peitao, TAN Lunfang, XIE Yanqing, GAO Yi, ZHENG Jinping
doaj   +1 more source

Determining Chronic Cough Using the Methacholine Bronchial Provocation Test

Jurnal Respirasi
Introduction: Chronic cough is a common symptom in pulmonology outpatient clinics, often associated with lung conditions, though extrapulmonary causes can also be responsible.
Esra Arslan Aksu, Oğuz Uzun
doaj   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Severe Occupational Hypersensitivity Pneumonitis: A Case Series of Four Patients Requiring Lung Transplantation

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Hypersensitivity pneumonitis (HP) is an immune‐mediated interstitial lung disease triggered by repeated inhalation of organic or chemical antigens. Occupational exposures account for approximately 19% of all cases. Early diagnosis, identification of the responsible antigen(s), and immediate avoidance of exposure are crucial to prevent ...
Ludwig Frei‐Stuber, Judith Mohren, Ester Mau, Bernhard Werner, Rudolf A. Hatz, Jürgen Barton, Dennis Nowak   +6 more
wiley   +1 more source

Assessment of Allergen-Induced Respiratory Hyperresponsiveness before the Prescription of a Specific Immunotherapy

Allergy & Rhinology, 2015
Background Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective The aim of this study was to appreciate and correlate the local and spirometric changes elicited by ...
Celso Eduardo Olivier M.D., Ph.D., Daiana Guedes Pinto Argentão B.Biomed, Regiane Patussi dos Santos Lima B.Biomed, Mariana Dias da Silva Pharm.D., Raquel Acácia Pereira Gonçalves dos Santos B.S.N., Natalia Fabbri D.Physio, Ph.D.   +5 more
doaj   +1 more source

Small Airway Function as an Indicator for Persistent Airflow Limitation Asthma: A Retrospective Study. [PDF]

Clin Respir J
ABSTRACT Background Asthma is a heterogeneous disease characterized by chronic inflammatory changes in the airways and reversible airflow limitation. Persistent airflow limitation (PAL) asthma, as a common phenotype of asthma, is usually defined as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) ratio lower than 0.7 after ...
Wang Z, Du X, Luo Y, Gong H, Tang H.
europepmc   +2 more sources

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Estudo da hiper-responsividade brônquica em pacientes portadores de refluxo gastroesofágico Bronchial hyperreactivity in patients with gastroesophageal reflux disease

Jornal Brasileiro de Pneumologia, 2005
OBJETIVO: O intuito deste trabalho foi evidenciar a existência desse reflexo vagal, através de uma broncoprovocação, em pacientes portadores de refluxo gastroesofágico.
Mônica Silveira Lapa, Roberto Rodrigues Júnior, Elie Fiss   +2 more
doaj   +1 more source

Hyperreactivity of the bronchi in children, whooping cough convalescents

Журнал инфектологии, 2020
Objective: to assess the presence and degree of bronchial hyperreactivity in convalescents of whooping cough based on the results of bronchial provocation tests.Materials and methods.
Yu. V. Nesterova, A. V. Orlov, I. V. Babachenko   +2 more
doaj   +1 more source