Results 81 to 90 of about 79,818 (276)

A Combined Model‐Based Meta‐Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model‐based meta‐analysis allows integration of aggregated‐level data (AD) from different clinical trials in one model to assess population efficacy/safety. However, AD is limited in individual‐level information, while individual‐patient‐level data (IPD) are hard to obtain. Combined modeling may take advantage of both sources.
Liang Yang, Carolina Llanos‐Paez, Shuying Yang, Claire Ambery, Alienor Berges, Maria C. Kjellsson, Mats O. Karlsson   +6 more
wiley   +1 more source

Nasal microRNA signatures for disease severity in infants with respiratory syncytial virus bronchiolitis: a multicentre prospective study

BMJ Open Respiratory Research
Background Respiratory syncytial virus (RSV) bronchiolitis contributes to a large morbidity and mortality burden globally. While emerging evidence suggests that airway microRNA (miRNA) is involved in the pathobiology of RSV infection, its role in the ...
Carlos A Camargo, Kohei Hasegawa, Zhaozhong Zhu, Tadao Ooka, Andrea Hahn, Marcos Pérez-Losada, Jonathan M Mansbach, Michihito Kyo, Ryohei Shibata, Brennan Harmon   +9 more
doaj   +1 more source

Nasopharyngeal fungal subtypes of infant bronchiolitis and disease severity riskResearch in context

EBioMedicine, 2023
Summary: Background: Bronchiolitis is a leading cause of infant hospitalization. Recent research suggests the heterogeneity within bronchiolitis and the relationship of airway viruses and bacteria with bronchiolitis severity.
Ryohei Shibata, Zhaozhong Zhu, Michihito Kyo, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Pérez-Losada, Carlos A. Camargo, Jr., Kohei Hasegawa   +8 more
doaj  

Epidemic dynamics of respiratory syncytial virus in current and future climates. [PDF]

, 2019
A key question for infectious disease dynamics is the impact of the climate on future burden. Here, we evaluate the climate drivers of respiratory syncytial virus (RSV), an important determinant of disease in young children.
Baker, Rachel E, Grenfell, Bryan T, Mahmud, Ayesha S, Metcalf, C Jessica E, Pitzer, Virginia E, Vecchi, Gabriel A, Viboud, Cecile, Wagner, Caroline E, Yang, Wenchang   +8 more
core   +2 more sources

Hyaluronic Acid‐Decorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis

Small Science, EarlyView.
Hyaluronic acid‐decorated imatinib‐loaded liposomes are developed to specific target CD44 receptor expressed by interstitial lung fibrosis cells, demonstrating higher uptake than empty liposomes. Based on promising in vitro data, they are administered intratracheally and intraperitoneally in a mouse bleomycin model, assessing their ability to decrease ...
Sara Bozzini, Valeria Bincoletto, Laura Pandolfi, Roberta Fusco, Rosanna Di Paola, Salvatore Cuzzocrea, Ilaria Andreana, Barbara Rolando, Eleonora Bozza, Cecilia Bagnera, Manuela Monti, Barbara Stella, Federica Meloni, Silvia Arpicco   +13 more
wiley   +1 more source

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus

Journal of Immunology Research, 2021
Background/Aim. Bronchiolitis is a common acute lower respiratory tract infectious disease in infants. Respiratory syncytial virus (RSV) infection is one of the main causes.
Liwen Zhang, Yu Wan, Liang Ma, Kaihong Xu, Baojin Cheng   +4 more
doaj   +1 more source

Factors Associated With Early Recurrence in Non‐Surgically Managed Primary Spontaneous Pneumothorax

World Journal of Surgery, EarlyView.
The indications for surgery in primary spontaneous pneumothorax (PSP) at first episode are clearly defined. Despite the indications, some patients avoid surgical treatment. This study examines the factors affecting early recurrence in patients who have not undergone surgical intervention.
Sercan Aydin, Seda Kahraman Aydin, Dilara Gursoy, Ayse Gul Ergonul, Tevfik Ilker Akcam, Kutsal Turhan, Ufuk Cagirici, Alpaslan Cakan, Omer Faruk Dadas   +8 more
wiley   +1 more source

Lung Injury Pathways: Adenosine Receptor 2B Signaling Limits Development of Ischemic Bronchiolitis Obliterans Organizing Pneumonia [PDF]

, 2017
Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. Materials and Methods: Ischemia was achieved by either left main pulmonary artery or complete hilar
Auchampach, John, Audi, Said H., Densmore, John C., Dwinell, Melinda R., Geurts, Aron M., Jacobs, Elizabeth R., Jeziorczak, Paul M., Medhora, Meetha, Nayak, Shraddha, Schaid, Terry R.   +9 more
core   +1 more source

Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective

World Medical &Health Policy, EarlyView.
ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley   +1 more source

Antenatal Corticosteroid Administration and Childhood Respiratory Morbidity: A Regression Discontinuity Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine if routine administration of antenatal corticosteroids affects the risk of infant lower respiratory tract infection and/or childhood asthma. Design Linked population‐based cohort analysed using a regression discontinuity design, which better controls for confounding than standard observational studies.
Jennifer A. Hutcheon, Sam Harper, M. Claire Cordingley, Jessica Liauw, M. Amanda Skoll, Peter M. Socha, Myriam Srour, Joseph Y. Ting, Erin C. Strumpf   +8 more
wiley   +1 more source