Results 211 to 220 of about 84,064 (299)

Investigation of the Effects of Perfluorooctane Sulfonic Acid (PFOS) and Perfluorooctanoic Acid (PFOA) Exposure on Interleukin‐17 Signalling and Poly(I:C)‐Induced Lung Inflammation in BALB/c Mice

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT The aim of this study was to investigate the effects of co‐exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on the IL‐17‐related immune responses and the Poly(I:C)‐induced lung inflammation. A total of 66 adult male BALB/c mice were divided into 11 groups, including controls, dose groups receiving PFOS+PFOA (1,
Eda Nur İnkaya   +2 more
wiley   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan   +17 more
wiley   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

open access: yesCancer Science, Volume 117, Issue 8, Page 2305-2316, August 2026.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai   +5 more
wiley   +1 more source

Evaluation of Global Immune Biomarkers to Predict Infections in Lung Transplant Recipients

open access: yesClinical Transplantation, Volume 40, Issue 8, August 2026.
ABSTRACT Background Immune biomarkers could assess levels of immunosuppression and predict infections in transplant recipients. We aimed to evaluate the absolute lymphocyte count (ALC), absolute neutrophil count (ANC), Quantiferon‐Monitor and the mitogen component of the Quantiferon‐CMV assay alone and combined to predict serious opportunistic ...
Quoc Nguyen   +6 more
wiley   +1 more source

The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity

open access: yesImmunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT CD4+ T cells orchestrate adaptive immunity against respiratory viruses through functionally distinct subsets, yet the qualitative differences between vaccine‐ and infection‐induced responses remain incompletely understood. This review summarizes current evidence on how CD4+ T cell subsets shape the magnitude, breadth, and durability of ...
Masato Kubo
wiley   +1 more source

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