Results 51 to 60 of about 83,414 (306)

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus

Respiratory Research, 2021
Although large advances have recently been made mapping out the cellular composition of lung tissue using single cell sequencing, the composition and distribution of the cellular elements within the lining fluid of the lung has not been extensively ...
S. D. Pouwels, Janette K. Burgess, Erik Verschuuren, Dirk-Jan Slebos   +3 more
doaj   +1 more source

Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid [PDF]

Journal of Antimicrobial Chemotherapy, 2000
The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BAL(f)) was investigated. Clinical respiratory isolates were added to BAL(f) suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine-BAL(f) compared with controls ...
K M, Olsen, T E, Peddicord, G D, Campbell, M E, Rupp   +3 more
openaire   +2 more sources

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Comparison of different microbiological procedures for the diagnosis of Pneumocystis jirovecii pneumonia on bronchoalveolar-lavage fluid

BMC Microbiology, 2022
Background The current diagnostic gold standard for Pneumocystis jirovecii is represented by microscopic visualization of the fungus from clinical respiratory samples, as bronchoalveolar-lavage fluid, defining “proven” P.
Iacopo Franconi, Alessandro Leonildi, Gianluca Erra, Roberta Fais, Marco Falcone, Emilia Ghelardi, Antonella Lupetti   +6 more
doaj   +1 more source

Cytokine production in bronchoalveolar lavage fluid.

, 2014
Results were reported as means ± SEM.*P
Chengcheng Ren (640883), Qiuxiang Zhang (216630), Chunqing Ai (640882), Xiaoming Liu (47653), Fengwei Tian (640884), Yong Q. Chen (193277), Gang Wang (36685), Jianxin Zhao (640885), Wei Chen (23863), Hao Zhang (15339)   +9 more
core   +1 more source

Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma

Animal Models and Experimental Medicine, EarlyView.
Lung maneuvers of small amplitudes, such as the ones performed in oscillometry, are the current gold standard to probe lung mechanics in animals, but they are insensitive to detect baseline physiological alterations in mouse models of asthma. Herein, lung maneuvers of different amplitudes were compared in two mouse models of asthma.
Magali Boucher, Cyndi Henry, Marie‐Josée Beaulieu, Andrés Rojas‐Ruiz, Ynuk Bossé   +4 more
wiley   +1 more source

Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis [PDF]

Lung, 2010
There has been only one report showing high levels of transferrin (Tf) in bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis. This study was designed to assess the levels of Tf in both BALF and serum and to examine the relationship between the levels of Tf and other disease markers in sarcoidosis.
Shigemura, Masahiko, Nasuhara, Yasuyuki, Konno, Satoshi, Hattori, Takeshi, Shimizu, Chikara, Matsuno, Kazuhiko, Nishimura, Masaharu   +6 more
openaire   +3 more sources

Increased levels of endothelin-1 in bronchoalveolar lavage fluid of patients with lung allografts

, 1996
The aim of the present study was to determine levels of endothelin-1 in bronchoalveolar lavage fluid and in plasma in patients with lung and heart-lung allografts.
McGregor, C.G.A., Nilsson, F.N., Miller, V.M., Mårtensson, G., Scherstén, H., Hedner, T., Riise, G.C.   +6 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source