Results 71 to 80 of about 84,064 (299)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Detection of Aspergillus spp. by PCR in Bronchoalveolar Lavage Fluid [PDF]

, 2001
peer reviewedThe usefulness of a nested PCR assay for detection of Aspergillus sp. DNA was evaluated in 177 bronchoalveolar lavage (BAL) fluid specimens.
G. Christiaens, Vaira, Dolorès, Suzin, Fabrice, D. Vaira, P. De Mol, F. Susin, M.-P. Hayette, P. Melin, Boland, Pascal, P. Boland, Hayette, Marie-Pierre, De Mol, Patrick, Christiaens, Geneviève, Melin, Pierrette   +13 more
core   +1 more source

Preservation and Utilization of Clinical Bronchoalveolar Lavage Fluid Specimen

Xiehe Yixue Zazhi
Bronchoalveolar lavage fluid (BALF) is rich in various bioactive substances such as cytokines and enzymes, making it a high-quality clinical specimen and research sample.
ZHANG Hui, LI Le, FANG Yun, YANG Ning, YUAN Xin, LIU Yan   +5 more
doaj   +1 more source

Prognostic Implications of Bronchoalveolar Fluid Analysis in Ventilator-Associated Pneumonia: An Observational Cohort Study

Egyptian Journal of Critical Care Medicine, 2022
Background Ventilator-associated pneumonia (VAP) is one of the most frequent infections with high mortality rates in intensive care units (ICUs) and the prediction of outcome is paramount in the decision-making process. Objective To assess the prognostic
Walid M. Kamel, Ahmad S. Fayed, Raef H. Emam, Ashraf W. Andraos   +3 more
doaj   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Comparison of the adherence of nontypeable haemophilus influenzae to lung epithelial cells

BMC Infectious Diseases
Objective Nontypeable Haemophilus influenzae (NTHi) plays an important role in respiratory tract infections, and adherence to lung epithelial cells is the first step in lung infections.
Yuwei Rong, Zihao Liu, Heping Wang, Zuguo Zhao   +3 more
doaj   +1 more source

Nested–polymerase chain reaction detection of f. sp. in a suspected immunocompromised Cavalier King Charles spaniel with multiple infections

SAGE Open Medical Case Reports, 2019
A 7-month-old Cavalier King Charles Spaniel female was referred due to a chronic cough refractory to antibiotic treatments. Laboratory findings showed leukocytosis, increased serum C-reactive protein, hypogammaglobulinemia, and decreased total serum ...
Matteo Petini, Tommaso Furlanello, Patrizia Danesi, Andrea Zoia   +3 more
doaj   +1 more source

Expression of complement-related membrane proteins on lymphocytes and alveolar macrophages in bronchoalveolar lavage fluid

Allergology International, 1998
Interstitial lung disease (ILD) can be separated into two groups: (i) that in which the causes are known; and (ii) that in which the etiologies have not been determined.
Risa Nakahara, Shuhei Takemura, Hideki Onodera, Yoshihiro Kasamatsu, Nobuyuki Seto, Naoko Ichio, Takashi Doi, Sadanobu Nakanishi, Masayuki Okamoto, Kunio Yanagida, Masahiro Ueda, Masako Deguchi, Motoharu Kondo   +12 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. [PDF]

, 2007
BACKGROUND: Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV).
Ed Zijlstra, Jambo Kondwani C, Zijlstra, Ed, Jambo, Kondwani C, Gordon, Stephen, French Neil, Jambo, Kondwani, Kondwani C Jambo, Neil French, Stephen B Gordon, French, Neil, Gordon, Stephen B, Zijlstra Ed, Gordon Stephen B, Kondwani C Jambo   +14 more
core   +1 more source