Results 241 to 250 of about 79,138 (287)
Some of the next articles are maybe not open access.
, 1994
Objective. —To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV 1 ) in smokers aged 35 to 60 years who have mild obstructive ...
N. Anthonisen +97 more
semanticscholar +1 more source
Objective. —To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV 1 ) in smokers aged 35 to 60 years who have mild obstructive ...
N. Anthonisen +97 more
semanticscholar +1 more source
Journal of Applied Physiology, 1992
Recent advances in computed tomographic imaging provide a unique method to serially and directly visualize acute physiological response in the lung. To directly investigate the airway response to hypoxia, high-resolution computed tomographic scans of the lungs of eight intact anesthetized minipigs were serially repeated before, during, and after ...
R C, Wetzel +3 more
openaire +2 more sources
Recent advances in computed tomographic imaging provide a unique method to serially and directly visualize acute physiological response in the lung. To directly investigate the airway response to hypoxia, high-resolution computed tomographic scans of the lungs of eight intact anesthetized minipigs were serially repeated before, during, and after ...
R C, Wetzel +3 more
openaire +2 more sources
Bronchodilator testing: confidence intervals derived from placebo inhalations.
American Review of Respiratory Disease, 2015We developed criteria for a statistically significant response to an inhaled bronchodilator by measuring changes in spirometry during blinded placebo inhalation in 40 patients referred to our pulmonary function laboratory for routine testing. Ninety-five
R. L. Sourk, K. Nugent
semanticscholar +1 more source
Pharmacology and Therapeutics of Bronchodilators
Pharmacological Reviews, 2012Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of the current management of chronic obstructive pulmonary disease (COPD) and are critical in the symptomatic management of asthma, although controversies around the use of these drugs remain. Bronchodilators work through their direct relaxation effect on airway
Cazzola M +3 more
openaire +5 more sources
American Review of Respiratory Disease, 2015
Response to bronchodilator aerosols delivered by metered dose inhalers (MDI) depends in part upon the amount of drug depositing on the airways. Ideally, the MDI should be actuated during a slow deep inhalation followed by a breathholding pause, an ...
M. Tobin +5 more
semanticscholar +1 more source
Response to bronchodilator aerosols delivered by metered dose inhalers (MDI) depends in part upon the amount of drug depositing on the airways. Ideally, the MDI should be actuated during a slow deep inhalation followed by a breathholding pause, an ...
M. Tobin +5 more
semanticscholar +1 more source
Current Opinion in Pharmacology, 2012
Bronchodilators are central in the treatment of airway diseases including chronic obstructive pulmonary disease (COPD). Bronchodilators in COPD aim to improve lung function, reduce symptoms, prevent exacerbation, and enhance quality of life. The majority of programs in development for novel bronchodilators are focused on enhancing existing targets to ...
Garbo, Mak, Nicola A, Hanania
openaire +2 more sources
Bronchodilators are central in the treatment of airway diseases including chronic obstructive pulmonary disease (COPD). Bronchodilators in COPD aim to improve lung function, reduce symptoms, prevent exacerbation, and enhance quality of life. The majority of programs in development for novel bronchodilators are focused on enhancing existing targets to ...
Garbo, Mak, Nicola A, Hanania
openaire +2 more sources
Clinics in Chest Medicine, 1989
Bronchodilator response is usually tested to establish reversibility of airflow obstruction, to aid in diagnosis, and to help plan long-term bronchodilator therapy. Among the various tests to establish bronchodilator response, FEV1, FEF25-75% or FEF50%, and FVC are the most widely used.
openaire +2 more sources
Bronchodilator response is usually tested to establish reversibility of airflow obstruction, to aid in diagnosis, and to help plan long-term bronchodilator therapy. Among the various tests to establish bronchodilator response, FEV1, FEF25-75% or FEF50%, and FVC are the most widely used.
openaire +2 more sources
Novel bronchodilators in asthma
Current Opinion in Pulmonary Medicine, 2010Because of the central role of bronchodilators in the treatment of asthma, in recent years there has been a renewed interest in the field and now once-daily bronchodilators are in development in an attempt to simplify their use.A variety of beta2-agonists with long half-lives, also called ultra long-acting beta2-agonists (ultra-LABAs; indacaterol ...
CAZZOLA M +2 more
openaire +4 more sources
Archives of Internal Medicine, 1979
From the clinician's standpoint, an ideal bronchodilator should have (1) selectivity for bronchial smooth muscle, (2) minimal stimulatory effects on the cardiovascular and central nervous system, (3) prolonged action, (4) rapid onset of action, and (5) oral effectiveness for patient convenience. In addition, bronchodilation should occur in both central
openaire +3 more sources
From the clinician's standpoint, an ideal bronchodilator should have (1) selectivity for bronchial smooth muscle, (2) minimal stimulatory effects on the cardiovascular and central nervous system, (3) prolonged action, (4) rapid onset of action, and (5) oral effectiveness for patient convenience. In addition, bronchodilation should occur in both central
openaire +3 more sources
Journal of the American Medical Association (JAMA), 1995
OBJECTIVE To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV1) in smokers aged 35 to 60 years who have mild obstructive ...
N. R. Anthoisen +13 more
semanticscholar +1 more source
OBJECTIVE To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV1) in smokers aged 35 to 60 years who have mild obstructive ...
N. R. Anthoisen +13 more
semanticscholar +1 more source