Results 201 to 210 of about 20,435 (278)
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In vitro studies on the relative potency of bronchodilator agents
Lung, 1985This study describes a rapid in vitro assay for the order of potency of bronchodilator drugs using specific binding of (−)-[3H] dihydroalprenolol ([3H]DHA) to rat lung membranes. Under linear conditions with respect to tissue, specific binding of [3H]DHA showed saturability, rapid kinetics of association and dissociation of radioligand, and ...
Joseph H. Fleisher, Jacob L. Pinnas
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ChemInform Abstract: TRICYCLIC QUINUCLIDYLIDENES AS POTENTIAL ANTIHISTAMINE‐BRONCHODILATING AGENTS
Chemischer Informationsdienst, 1975AbstractAus den Oxo‐Verbindungen (I) erhält man mit 3‐Chlorchinuclidin (II) in Gegenwart von Na die Carbinole (III), aus (IV) erhält man über das Li‐Derivat mit 3‐Chinuclidon (V) die Carbinole (VI).
F. J. Villani +2 more
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Journal of Medicinal Chemistry, 1975
The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the ...
F J, Villani +11 more
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The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the ...
F J, Villani +11 more
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LG 30435 is a new bronchodilator agent with multiple sites of action
European Journal of Pharmacology, 1986LG 30435, a new quaternary derivative of the H1-histamine antagonist mequitazine, was evaluated against bronchospasm induced by different agonists. This compound inhibited equipotently methacholine- and histamine-induced contractions of isolated guinea-pig trachea. When administered to guinea-pig by the i.v. and/or the aerosol route, LG 30435 inhibited
Marco Criscuoli +2 more
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The variable effect of a bronchodilating agent on pulmonary function in cystic fibrosis
The Journal of Pediatrics, 1973Nine of 50 patients with cystic fibrosis were found to have a measurable response to bronchodilators. The maximum expiratory flow-volume curve was the most sensitive test for detecting it. Of these nine patients, five improved and could be considered to have an associated asthmatic diathesis.
L.I. Landau, P.D. Phelan
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Humidification, Nebulization, and Bronchodilator Agents
1978These defense mechanisms include: (a) ciliary escalator system—the mucus carpet carrying microorganisms and small foreign particles at a normal rate of about 1 cm/min from bronchioles and bronchi to the larynx entrance, (b) coughing, and (c) phagocytosis—macrophages in alveoli clearing via interstitial spaces (lymphatics) and upward via the ciliary ...
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Journal of Pharmaceutical Sciences, 1967
A technique for measuring pulmonary resistance to airflow without the interference of compliance changes was used to obtain data on the bronchodilator activity of ephedrine sulfate and methoxyphenamine hydrochloride. The resting pulmonary resistance of cats was increased by injecting histamine (100 mcg., base, i.v.) or 5-hydroxytryptophan creatinine ...
Leon C. Greene +2 more
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A technique for measuring pulmonary resistance to airflow without the interference of compliance changes was used to obtain data on the bronchodilator activity of ephedrine sulfate and methoxyphenamine hydrochloride. The resting pulmonary resistance of cats was increased by injecting histamine (100 mcg., base, i.v.) or 5-hydroxytryptophan creatinine ...
Leon C. Greene +2 more
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Archives of Pharmacal Research, 2012
Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma. Recently, it was found that bacterial infection has a role in asthma pathogenesis. The present work involves the design and synthesis of 8-substituted theophylline derivatives as bronchodilators and antibacterial agents.
Abdel Alim M. Abdel Alim +2 more
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Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma. Recently, it was found that bacterial infection has a role in asthma pathogenesis. The present work involves the design and synthesis of 8-substituted theophylline derivatives as bronchodilators and antibacterial agents.
Abdel Alim M. Abdel Alim +2 more
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Bronchodilator Responses to Anticholinergic and Beta-Adrenergic Agents in Acute and Stable COPD
Chest, 1991Patients with COPD may respond differently to anticholinergic and beta-agonist bronchodilators. Previously, in acutely ill COPD patients, we showed similar improvements in pulmonary function after each drug (study 1). The responses of the same patients when stable are now reported (study 2). Patients received ipratropium bromide (54 micrograms) (n = 16)
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Respiration, 1978
The development of beta2-specific sympathomimetic bronchodilators (rimiterol, salbutamol, terbutaline) has made the basic treatment of asthmatic patients more safe and effective. Despite that, the asthmatics should be under careful control and all patients should be taught the correct way to use their bronchodilator aerosols.
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The development of beta2-specific sympathomimetic bronchodilators (rimiterol, salbutamol, terbutaline) has made the basic treatment of asthmatic patients more safe and effective. Despite that, the asthmatics should be under careful control and all patients should be taught the correct way to use their bronchodilator aerosols.
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