Results 141 to 150 of about 56,629 (301)

Big Bear billboard near Main street

, 1930
A long and narrow billboard, near the 2030 East Main Street store, helping to introduce Big Bear's second supermarket. The billboard reads, "Big Bear: The one complete, one stop stop super food market.
Big Bear
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H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

The Big Bear family album

, 1984
Photograph album created by Big Bear supermarkets to celebrate their 50th anniversary. The cover reads, " The Big Bear Family Album: The First 50 Years: 1934-1984 [50 Years: Quality Supermarkets Since 1934]." The first pages of the album give a brief ...
Big Bear
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Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Canned goods at the North High street Big Bear location

, 1948
Canned goods at 1101 North High Street Big Bear location, in October of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
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Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Sex, size, and dependent young influence how brown bears select habitat relative to salmon streams

Global Ecology and Conservation
To survive and reproduce, animals must balance resource acquisition with mortality avoidance and thus should maximize food intake while minimizing risk.
Sarah L. Schooler, Nathan J. Svoboda, Shannon P. Finnegan, Jerrold L. Belant   +3 more
doaj   +1 more source

Canned goods at the Newark Big Bear location

, 1940
Canned goods at the Newark, Ohio Big Bear location. This store opened on July 1, 1940 and was remodeled in September of 1962. Big Bear is responsible for many innovations in the supermarket business.
Big Bear
core  

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Canned goods at the Toledo Big Bear location

, 1940
Canned goods at the 350 West Central Ave. Toledo, Ohio Big Bear location, in September of 1940. Big Bear is responsible for many innovations in the supermarket business.
Big Bear
core