Results 151 to 160 of about 56,629 (301)

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao   +19 more
wiley   +1 more source

Produce at the Lancaster Big Bear location

open access: yes, 1940
Produce department at the Lancaster, Ohio Big Bear location. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
core  

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

Big Bear stores company common stock report

open access: yes, 1957
Common Stock report for Big Bear stores. The cover reads, "325,000 shares Big Bear Stores Company Class A Common Stock Price: $10.00 per share. The Ohio Company Investments | 51 N. High St. CApital 1-4431 Columbus 15, Ohio.
Big Bear
core  

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

open access: yesAdvanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim   +2 more
wiley   +1 more source

Color photograph of the Big Bear 1958 nerve center

open access: yes, 1953
Color photo from Big Bear Stores annual report in 1958, showing the memory drum used in connection with the RAMAC computer. The description reads, "At left is the fabuous memory drum used in con-nection with the RAMAC equipment on which is recorded the ...
Big Bear
core  

Sustainable Carbon Fibers Enable Stable Long‐Term Lithium Metal Deposition for Prospective Zero‐Excess Lithium Metal Batteries

open access: yesAdvanced Energy Materials, EarlyView.
This work presents lightweight, lignin‐derived carbon fiber current collectors that enable controlled lithium deposition. Structural defects and intermediate‐sized pores stabilize pre‐nucleation quasi‐metallic lithium clusters, promoting uniform lithium plating and stripping.
Samantha L. S. Southern   +13 more
wiley   +1 more source

Photograph of cattle at Big Bear Farms

open access: yes, 1962
Black and white photograph of cattle and Big Bear stores President, Wayne E. Brown, at Big Bear Farms in Powell, Ohio. Big Bear Farms provided a good portion of the meats offered by the self service Big Bear chain stores. The farm was located near Powell,
Big Bear
core  

Asymmetric Multi‐Site Ion Exchange in Porous Carbon Electrodes

open access: yesAdvanced Energy Materials, EarlyView.
A lognormal‐distribution 2D EXSY NMR framework uncovers the full spectrum of ion dynamics in hierarchical porous carbons, bridging fast surface exchange and confined in‐pore transport—establishing structure–transport relationships for next‐generation energy storage, gas storage, and ion removal materials.
Henry R. N. B. Enninful   +5 more
wiley   +1 more source

Extreme Weather Events and Consumer Food Responses

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study investigates consumer food responses to Hurricanes Helene and Milton, which affected a swath of the Southeastern U.S. in 2024. Using representative consumer survey data from six affected states, we analyze 10 distinct food responses classified into ex ante and ex post responses, and examine their associations with food insufficiency
Ahmad Zia Wahdat, Joseph Balagtas
wiley   +1 more source

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