Results 91 to 100 of about 350 (114)
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Nanoscience and Nanotechnology Letters, 2020
This study aimed to investigate the effect of bruceine D on the proliferation and apoptosis of human retinoblastoma cells and its effect on miR-155 expression. Y79 human retinoblastoma cells were cultured in vitro and randomly divided into the blank control group, DMSO (Dimethyl Sulphoxide) group, bruceine D 10 μmol/L group, bruceine D 20 μmol/L group,
Dongju Qin +4 more
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This study aimed to investigate the effect of bruceine D on the proliferation and apoptosis of human retinoblastoma cells and its effect on miR-155 expression. Y79 human retinoblastoma cells were cultured in vitro and randomly divided into the blank control group, DMSO (Dimethyl Sulphoxide) group, bruceine D 10 μmol/L group, bruceine D 20 μmol/L group,
Dongju Qin +4 more
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Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways
Cancer Letters, 2017Hepatocellular carcinoma (HCC) is known for high mortality and limited available treatments. Aberrant activation of the Wnt and Notch signaling pathways is critical to liver carcinogenesis and progression. Here, we identified a small molecule, bruceine D (BD), as a Notch inhibitor, using an RBP-Jκ-dependent luciferase-reporter system.
Ziying Cheng +15 more
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HPLC–MS/MS method for bioavailability study of bruceines D & E in rat plasma
Journal of Chromatography B, 2017Bruceines D and E are quassinoids from seeds of Brucea javanica (L.) Merr. exhibiting hypoglycemia effect. The crude drug is used as a traditional medicine by diabetes patients. The aim of this study is to understand the bioavailability and pharmacokinetics of both the bruceines D & E. A rapid and sensitive HPLC-MS/MS method was developed and validated
Farahdina, Man, Chee-Yan, Choo
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Chinese Herbal MedicinesAbstract B23: Brucein D suppresses pancreatic tumor growth in a mouse orthotopic nude model.
Therapy, 2012Pancreatic cancer is one of the most lethal cancers and has a 5-year survival rate less than 5.5% under the best available cancer treatment [1]. Currently, gemcitabine-based therapy remains to be the mainstay for advanced pancreatic cancer; however, the median survival time is less than 6 months for these patients [2, 3].
Ling Liu, Zhi Xiu Lin, Po Sing Leung
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Journal of Investigative Medicine, 2023
Owing to the high rates of relapse and migration, ovarian cancer (OC) has been recognized as the most lethal gynecological malignancy worldwide. The activity of the epidermal growth factor receptor (EGFR) signaling pathway is frequently associated with OC cell proliferation and migration.
Jufan, Zhu +6 more
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Owing to the high rates of relapse and migration, ovarian cancer (OC) has been recognized as the most lethal gynecological malignancy worldwide. The activity of the epidermal growth factor receptor (EGFR) signaling pathway is frequently associated with OC cell proliferation and migration.
Jufan, Zhu +6 more
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Bruceine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464
Chemical Biology & Drug Design, 2023AbstractBruceine D (BD) from Brucea javanica (L) exerts an antitumor effect in several human cancers. At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. Therefore, investigating the role and regulatory mechanisms of BD in CRC is the main thrust of this study.
Yong, Yang +4 more
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Biochemical and Biophysical Research Communications, 2020
Parkinson's disease (PD) is neurodegenerative disease, featured by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), characteristic motor symptoms and cognitive impairment. Development of effective therapeutic drugs for PD is necessary.
Yan, Yang +5 more
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Parkinson's disease (PD) is neurodegenerative disease, featured by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), characteristic motor symptoms and cognitive impairment. Development of effective therapeutic drugs for PD is necessary.
Yan, Yang +5 more
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Phytomedicine, 2019
Spinal muscular atrophy (SMA) is a rare neuromuscular disease and a leading genetic cause of infant mortality. SMA is caused primarily by the deletion of the survival motor neuron 1 (SMN1) gene, which leaves the duplicate gene SMN2 as the sole source of SMN protein.
Yang Hee Jo, Miri Choi, Hyung Won Ryu
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Spinal muscular atrophy (SMA) is a rare neuromuscular disease and a leading genetic cause of infant mortality. SMA is caused primarily by the deletion of the survival motor neuron 1 (SMN1) gene, which leaves the duplicate gene SMN2 as the sole source of SMN protein.
Yang Hee Jo, Miri Choi, Hyung Won Ryu
exaly +3 more sources
Isolation and structure of 15-O-benzoyl-brucein d, a new quassinoid from (x-ray analysis)1
Tetrahedron Letters, 1985Abstract The structure of 15-O-benzoyl-brucein D, a new quassinoid isolated from Soulamea amara Lam., has been established from spectral data and by single-crystal X-ray analysis ; the previously known picrasin B, isobrucein A and B were also isolated.
Subodh Bhatnagar +3 more
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