Results 81 to 90 of about 350 (114)

In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

Veterinary Parasitology, 2011
The present study was designated to ascertain the anthelmintic activity of the dried fruits of Brucea javanica and to isolate and characterise the active constituents. The methanol extract from the fruits of B. javanica showed significant anthelmintic activity against Dactylogyrus intermedius (EC(50) (median effective concentration) value=49.96 mg l(-1)
Gao-Xue Wang, Jing Han
exaly   +3 more sources

Bruceine D Sensitizes Human Ovarian Cancer Cells to Paclitaxel Through JNK and STAT3 Signal Regulation

Revista Brasileira De Farmacognosia, 2022
AbstractExploring novel regimens is essential to ensure the efficacy of paclitaxel-based chemotherapy in epithelial ovarian cancer. Brucea javanica (L.) Merr., Simaroubaceae, oil emulsion benefits the patients who received sequential chemotherapy, and bruceine D is identified as the major active tetracyclic quassinoid.
Zhipeng Yan, Zhihong Jin, Hongying Sui   +2 more
exaly   +2 more sources

Bruceine D Acts as a Potential Insecticide by Antagonizing 20E–EcR/USP Signal Transduction

Journal of Agricultural and Food Chemistry, 2023
Bruceine D (BD) is an effective insecticidal compound found in the Chinese herb Brucea javanica (L.) Merr. BD inhibits the growth and metamorphosis of Plutella xylostella and Drosophila melanogaster; however, its target protein and the molecular mechanism of insecticidal activity remain unclear.
Dongping Chen, Kang Li, Bingfeng Wang, Huimin Chen, Heng Jiang, Chen Zhao, Guangkai Yao, Sheng Li, Hanhong Xu   +8 more
openaire   +2 more sources

Development and validation of a sensitive LC–MS/MS assay for quantification of bruceine D in rat plasma

Biomedical Chromatography, 2016
AbstractA sensitive LC–MS/MS method for the determination of bruceine D in rat plasma was developed. The analyte and IS were separated on a Luna C18 column (2.1 × 50 mm, 1.7 μm) using a mobile phase of acetonitrile and 0.1% formic acid in water (40:60, v/v) at a flow rate of 0.25 mL/min.
Yong Zhen
exaly   +3 more sources

Bruceine D induces apoptosis in human non-small cell lung cancer cells through regulating JNK pathway

Biomedicine and Pharmacotherapy, 2019
Bruceine D (BD) is the quassinoids isolated from the traditional Chinese herbal medicine Brucea javanica's fruit, which exhibits anti-cancer activity. Here, we demonstrated that BD inhibited human non-small cell lung cancer (NSCLC) cell lines in vitro that were attributed to the induction of cell apoptosis.
Biqin Tan, Lihua Lan, Lijun Ye
exaly   +3 more sources

Bruceines D, E and H

Journal of Heterocyclic Chemistry, 1989
AbstractThe absolute stereochemistry of bruceines D, E and H has been confirmed to be 1S, 5S, 7R, 8R, 9R, 10S, 11R, 12S, 13R, 14R, 15R and additionally 2S for bruceine E by a combination of 2D nmr [1H‐1H and 1H‐13C (one‐bond and long‐range) COSY] nOe and cd spectroscopic analyses.
Xian Li, Lijun Wu, Yaeko Konda, Mieko Iguchi, Hiroshi Takahasi, Yoshihiro Harigaya, Masayuki Onda   +6 more
openaire   +1 more source

Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway

IUBMB Life, 2022
AbstractThe Akt signaling pathway is an oncogenic cascade activated in the bone marrow microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled proliferation. Abrogation of Akt signaling has been presented as one of the prime therapeutic targets in the treatment of MM.
Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Jae‐Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn   +7 more
openaire   +2 more sources

Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma

European Journal of Pharmacology, 2014
Brucea javanica fruit has been used to treat amebic dysentery, malaria and various parasites and it has been applied as an anti-cancer agent in Traditional Chinese Medicine. Brucein D (BD) is a naturally occurring compound extracted from Brucea javanica fruit which shows anti-cancer activity against pancreatic cancer. Here, we further demonstrated that
Zhangang, Xiao, Sheung, Ching Chow, Chi, Han Li, Shing, Chun Tang, Stephen K W, Tsui, Zhixiu, Lin, Yangchao, Chen   +6 more
openaire   +2 more sources

Antiphytoviral activity of bruceine‐D from Brucea javanica seeds

Pest Management Science, 2007
AbstractBACKGROUND: Brucea javanica (L.) Merr. is widely distributed throughout the southern parts of China and has been used in traditional medicine to treat a variety of diseases. The objective of the present study was to identify the active antiphytoviral compound in the seeds of B.
Jian-Guo, Shen, Zheng-Kun, Zhang, Zu-Jian, Wu, Ming-An, Ouyang, Lian-Hui, Xie, Qi-Ying, Lin   +5 more
openaire   +2 more sources

Exploring the mechanism of Bruceine D against cervical cancer by network pharmacology and the effect of Bruceine D on the EGFR pathway

Journal of Pharmaceutical and Biomedical Analysis
Cervical cancer (CC) remains a formidable challenge in oncology due to its high incidence and mortality rates. Despite recent advances in treatment, an immediate necessity exists for innovating advanced pharmacological interventions boasting augmented effectiveness.
Ju-Fan, Zhu, Yuan-Qiu, Wang, Si-Meng, Yang, Yu-Li, Wang, Yan, Hu, Xin-Yue, Dai   +5 more
exaly   +3 more sources