Results 71 to 80 of about 109,971 (317)

RomA, A Periplasmic Protein Involved in the Synthesis of the Lipopolysaccharide, Tunes Down the Inflammatory Response Triggered by Brucella [PDF]

, 2018
Brucellaceae are stealthy pathogens with the ability to survive and replicate in the host in the context of a strong immune response. This capacity relies on several virulence factors that are able to modulate the immune system and in their structural ...
Altabe, Silvia Graciela, Casabuono, Adriana Cristina, Cassataro, Juliana, Couto, Alicia Susana, Czibener, Cecilia, Fulgenzi, Fabiana Rosa, Guaimas, Francisco Fernando, Pasquevich, Karina Alejandra, Spera, Juan Manuel, Ugalde, Juan Esteban, Valguarnera, Pablo Ezequiel   +10 more
core   +1 more source

Immunopathology of Brucella Infection

Recent Patents on Anti-Infective Drug Discovery, 2013
In spite of the protean nature of the disease, inflammation is a hallmark of brucellosis and affected tissues usually exhibit inflammatory infiltrates. As Brucella lacks exotoxins, exoproteases or cytolysins, pathological findings in brucellosis probably arise from inflammation-driven processes.
Baldi, Pablo Cesar, Giambartolomei, Guillermo Hernan   +1 more
openaire   +4 more sources

Brucellosis remains a neglected disease inthe developing world: a call forinterdisciplinary action [PDF]

, 2018
Brucellosis places significant burdens on the human healthcare system and limits the economic growth of individuals, communities, and nations where such development is especially important to diminish the prevalence of poverty.
A Fournier, A Gregoire, A. M. Arenas-Gamboa, AH Al-Talafhah, AM Arenas-Gamboa, AS Dean, AS Dean, B Megersa, B Schumaker, B. N. Häsler, BB Asiimwe, BB Singh, C Jo, CW Cooper, D Grace, D Merriott, E Herrera, E Moreno, EL Prado, F Roth, FF Tuon, FP Poester, G Vilchez, II Musallam, J Godfroid, J McDermott, J Rushton, J Zinsstag, JA Assenga, JJ McDermott, K Pedersen, K. A. Franc, MN Seleem, NE Lucero, O Vered, P Chand, PH Bamaiyi, R Strasser, R. C. Krecek, S Kose, SC Olsen, SC Welburn, SS Mandal, TR Kelly, TW Roberts, V Racloz, YM Hegazy   +46 more
core   +1 more source

Immune Response to Mucosal Brucella Infection

Frontiers in Immunology, 2019
Brucellosis is one of the most prevalent bacterial zoonosis of worldwide distribution. The disease is caused by Brucella spp., facultative intracellular pathogens.
R. López-Santiago, Ana Beatriz Sánchez-Argáez, Liliana Gabriela De Alba-Núñez, S. Baltierra-Uribe, M. Moreno-Lafont   +4 more
semanticscholar   +1 more source

Systematic review of brucellosis in the Middle East: disease frequency in ruminants and humans and risk factors for human infection [PDF]

, 2007
This paper considers the problem of finding global states incoming to a specified global state in a Boolean network, which may be useful for pre-processing of finding a sequence of control actions for a Boolean network and for identifying the basin of ...
Abo-Shehada, M N, Guitian, J, Hegazy, Y M, Holt, H R, Musallam, I I   +4 more
core   +2 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The Phospholipid N-Methyltransferase and Phosphatidylcholine Synthase Pathways and the ChoXWV Choline Uptake System Involved in Phosphatidylcholine Synthesis Are Widely Conserved in Most, but Not All Brucella Species

Frontiers in Microbiology, 2021
The brucellae are facultative intracellular bacteria with a cell envelope rich in phosphatidylcholine (PC). PC is abundant in eukaryotes but rare in prokaryotes, and it has been proposed that Brucella uses PC to mimic eukaryotic-like features and avoid ...
Beatriz Aragón-Aranda, Leyre Palacios-Chaves, Miriam Salvador-Bescós, María Jesús de Miguel, María Jesús de Miguel, Pilar M. Muñoz, Pilar M. Muñoz, Miguel Ángel Vences-Guzmán, Amaia Zúñiga-Ripa, Leticia Lázaro-Antón, Christian Sohlenkamp, Ignacio Moriyón, Maite Iriarte, Raquel Conde-Álvarez   +13 more
doaj   +1 more source

Culture Positive Brucella Endocarditis in a Case of Baloon Mitral Valvotomy [PDF]

, 2011
Brucella endocarditis is a rare condition which occurs as a focal complication in chronic brucellosis cases. We report a rare brucella endocarditis case in a RVHD patient. A 26 years old male was admitted with fever on off for almost one year.
Aundhkar, S, Ghorpade, MV, Pawar, SK
core  

Acute brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors [PDF]

, 2015
Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNFα) medication.
Akalın, Ş., Demirkan, N., Ergin, Ç., Kutlu, Murat, Sayin-Kutlu, S., Zorbozan, O., Çobankara, V., Şahin, B., Şen-Türk, N.   +8 more
core   +1 more source

Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin‐Independent Regulation of Fpn mRNA

American Journal of Hematology, EarlyView.
ABSTRACT The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) by inhibiting the iron exporter ferroportin in target cells, causing hypoferremia. Under acute inflammation, hepcidin induction requires hemojuvelin (Hjv), a bone morphogenetic protein co‐receptor, while Fpn mRNA is also suppressed in a hepcidin‐
Siqi Liu, Sofiya Tsyplenkova, Carine Fillebeen, Kostas Pantopoulos   +3 more
wiley   +1 more source