Results 51 to 60 of about 16,632 (223)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Treatment of Electrical Storm with Amiodarone in Brugada Syndrome- an Unexpected Protective Effect [PDF]

, 2013
We are reporting on a 53 year old man with proven Brugada syndrome and ICD implantation for resuscitation in context of polymorphic VT. After recurrent arrhythmia he was treated with Amiodarone.
Novak, J, Lambiase, PD
core  

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

ONCOLOGIC BRUGADA

Journal of the American College of Cardiology
Structural abnormalities within the right ventricular outflow tract (RVOT) can present similarly to Brugada syndrome. A 34-year-old woman with no medical history presented with polymorphic ventricular tachycardia/ventricular fibrillation cardiac arrest and initial electrocardiogram showed type I Brugada pattern.
Julia Bast, Mallette Asmuth, Nicole Prabhu, Lavanya Kondapalli, Raymundo A. Quintana   +4 more
openaire   +2 more sources

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Pathogenesis and management of Brugada syndrome [PDF]

, 2016
Brugada syndrome is an inherited disease characterized by an increased risk of sudden cardiac death owing to ventricular arrhythmias in the absence of structural heart disease.
Gregory Dendramis, Pedro Brugada, Sieira Rodriguez-Moret, Juan Antonio, Brugada, Pedro, Juan Sieira, Dendramis, Gregory   +5 more
core   +1 more source

Model of nursing care for patients with Brugada syndrome according to the international ICNP®

Journal of Education, Health and Sport, 2019
Introduction Brugada syndrome is a rare disease involving genetic disorders of heart rhythm. The disease was discovered in 1992 by the Brugada brothers, Spanish cardiologists.
Aleksandra Stosiek, Jowita Pryszcz, Dominik Budzyna-Dawidowski, Beata Jankowska-Polańska   +3 more
doaj   +3 more sources

Case Report: Lurasidone-Induced Type 2 Brugada Pattern in a Pediatric Patient

Clinical Practice and Cases in Emergency Medicine
Introduction: Brugada syndrome, a cardiac channelopathy, manifests with ventricular arrhythmia. Diagnosis relies on a type 1 Brugada electrocardiogram (ECG) pattern, while type 2 and type 3 patterns may necessitate electrophysiologic testing to uncover ...
Ethan Start, Aldrin Enabore
doaj   +1 more source

Padrão de Brugada tipo 1 induzido pela febre

Revista Portuguesa de Cardiologia, 2015
Resumo: A síndrome de Brugada, descrita há cerca de 20 anos, caracteriza‐se eletrocardiograficamente por uma elevação convexa do segmento‐ST nas derivações precordiais direitas e pelo elevado risco de morte súbita em jovens aparentemente saudáveis.Este ...
Marta Madeira, Francisca Caetano, Rui Providência, Inês Almeida, Joana Trigo, José Nascimento, Marco Costa, António Leitão Marques   +7 more
doaj   +1 more source

Long‐Term Serial Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia on Beta‐Blocker and Flecainide Therapy

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially life‐threatening arrhythmic disorder typically treated with beta‐blockers and, occasionally, with flecainide. Methods All patients underwent genetic testing, electrocardiogram, echocardiogram, and exercise testing.
Fernando Wangüemert‐Perez, German Ostos‐Cañero, Marta Wangüemert‐Guerra, Carlos Acosta‐Materan, Aridane Cárdenes‐león, Eduardo Caballero‐Dorta, Kevin Pérez‐Rodríguez, Ramón Brugada, Josep Brugada, Efrén Martínez‐Quintana   +9 more
wiley   +1 more source