Results 71 to 80 of about 18,700 (219)

Speckle tracking echocardiography data in Brugada syndrome patients

Data in Brief, 2019
Brugada syndrome is characterized by typical electrocardiogram changes and a high risk for sudden cardiac death (Priori et al., 2013). In addition to the well known electrical substrate, morphological and functional alterations appeared to be present in ...
Esther Scheirlynck, Sophie Van Malderen, Andreea Motoc, Øyvind H. Lie, Carlo de Asmundis, Juan Sieira, Gian-Battista Chierchia, Pedro Brugada, Bernard Cosyns, Steven Droogmans   +9 more
doaj   +1 more source

Syncope following Pfizer BioNTech (bnt162b2) vaccination unmasking Brugada syndrome

Heliyon, 2023
The Brugada syndrome is an uncommon inherited condition associated with increased risk of ventricular tachyarrhythmias and sudden cardiac death. Different triggers including fever are well known to precipitate the Brugada pattern on electrocardiogram. We
Mohammad Altermanini, Mhd Baraa Habib, Dania Alkhiyami, Khaled Ali, Mohamed Salah Abdelghani, Tahseen Hamamyh, Ahmad Elyas, Mawahib Elhassan   +7 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Prevalence and characteristics of the Brugada electrocardiogram pattern in patients with arrhythmogenic right ventricular cardiomyopathy

Journal of Arrhythmia, 2021
Background Despite distinct pathophysiology, arrhythmogenic right ventricular cardiomyopathy (ARVC) and Brugada syndrome (BrS) exhibit overlapping phenotypes.
Nobuhiko Ueda, Satoshi Nagase, Naoya Kataoka, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Kenichiro Yamagata, Kohei Ishibashi, Yuko Inoue, Koji Miyamoto, Takashi Noda, Takeshi Aiba, Chisato Izumi, Teruo Noguchi, Seiko Ohno, Kengo Kusano   +15 more
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Sudden cardiac death due to adrenal insufficiency masquerading as Brugada syndrome. Case report

Евразийский Кардиологический Журнал
Sudden cardiac death in young people in 20% of cases is caused by cardiomyopathies and channelopathies. One of the forms of channelopathies is Brugada syndrome, a hereditary disease characterized by ST segment elevation in the right precordial leads (V1 ...
N. V. Kijvatova, N. V. Chumachenko, G. A. Golovina, H. V. Gordeeva, H. D. Kosmacheva   +4 more
doaj   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Adjusting for Medication Use in GWAS and Its Impact on Mendelian Randomisation Analyses: An Example of Systolic Blood Pressure in UK Biobank

Genetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT Medication use is common in large‐scale population cohorts, and can modify phenotypic traits of interest. This can potentially bias effect estimates in genome‐wide association studies (GWAS) and impact downstream analyses such as Mendelian randomisation (MR). The best approach to account for medication use in GWAS is unclear. In this study, we
Aaron Jun Yi Yap, Aimee L. Hanson, Gareth J. Griffith, Eleanor Sanderson   +3 more
wiley   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Brugada Syndrome or Brugada Electrocardiogram?

Journal of the American College of Cardiology, 2009
We read with great interest the paper by Benito et al. ([1][1]) from the Brugada group. The authors confirm that important differences exist between men and women regarding the clinical picture and outcome in patients with Brugada syndrome.
van den Berg, Maarten P., de Boer, Rudolf A., van Tintelen, J. Peter   +2 more
openaire   +2 more sources