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Genetic and Molecular Mechanisms in Brugada Syndrome
Cells, 2023 Brugada syndrome is a rare hereditary arrhythmia disorder characterized by a distinctive electrocardiogram pattern and an elevated risk of ventricular arrhythmias and sudden cardiac death in young adults.
Josep Brugada, Errol Moras
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Current Sports Medicine Reports, 2005
Brugada syndrome is a recognized cause of sudden cardiac death worldwide. An inherited ion channel abnormality produces abnormal repolarization leading to characteristic ST-segment elevation in precordial leads V1 to V3 and a pseudo right bundle branch block on electrocardiogram.
Erin B, Drifmeyer, Kenneth B, Batts
openaire +2 more sources
Brugada syndrome is a recognized cause of sudden cardiac death worldwide. An inherited ion channel abnormality produces abnormal repolarization leading to characteristic ST-segment elevation in precordial leads V1 to V3 and a pseudo right bundle branch block on electrocardiogram.
Erin B, Drifmeyer, Kenneth B, Batts
openaire +2 more sources
Current Opinion in Cardiology, 2007
The Brugada syndrome has been an area of intensive investigation since its earliest description in 1992, both on a clinical and on a basic research level. In this review, we will focus on recent achievements in the molecular dissection of the disease pathophysiology and on large multicenter studies dealing with prognostic markers and the natural ...
Rossenbacker T, PRIORI, SILVIA GIULIANA
openaire +2 more sources
The Brugada syndrome has been an area of intensive investigation since its earliest description in 1992, both on a clinical and on a basic research level. In this review, we will focus on recent achievements in the molecular dissection of the disease pathophysiology and on large multicenter studies dealing with prognostic markers and the natural ...
Rossenbacker T, PRIORI, SILVIA GIULIANA
openaire +2 more sources
Herzschrittmachertherapie + Elektrophysiologie, 2013
Brugada syndrome is an ion channel disease which is associated with an increased risk of sudden cardiac death. Most probably the pathogenesis of ventricular fibrillation in these patients is a combination of both genetically determined repolarisation abnormalities and conduction delay in the right ventricular epicardium.
Christian, Wolpert +4 more
openaire +2 more sources
Brugada syndrome is an ion channel disease which is associated with an increased risk of sudden cardiac death. Most probably the pathogenesis of ventricular fibrillation in these patients is a combination of both genetically determined repolarisation abnormalities and conduction delay in the right ventricular epicardium.
Christian, Wolpert +4 more
openaire +2 more sources
Acta Cardiologica, 2009
The Brugada syndrome is an inherited cardiac disorder initially described in 1992 by Pedro and Josep Brugada, with variable electrocardiographic features characteristic of right bundle-branch block, persistent ST-segment elevation in the precordial leads (VI-V3) at rest and sudden cardiac death.
Ricardo O, Escárcega +4 more
openaire +2 more sources
The Brugada syndrome is an inherited cardiac disorder initially described in 1992 by Pedro and Josep Brugada, with variable electrocardiographic features characteristic of right bundle-branch block, persistent ST-segment elevation in the precordial leads (VI-V3) at rest and sudden cardiac death.
Ricardo O, Escárcega +4 more
openaire +2 more sources
The American Journal of Emergency Medicine, 2003
Brugada syndrome describes the syndrome of sudden cardiac death in the setting of the following electrocardiographic findings: right bundle branch block pattern with ST-segment elevation in the right precordial leads. The right bundle branch block may be incomplete while the ST segment elevation is minimal.
Amal, Mattu +4 more
openaire +2 more sources
Brugada syndrome describes the syndrome of sudden cardiac death in the setting of the following electrocardiographic findings: right bundle branch block pattern with ST-segment elevation in the right precordial leads. The right bundle branch block may be incomplete while the ST segment elevation is minimal.
Amal, Mattu +4 more
openaire +2 more sources
Cardiac Electrophysiology Clinics, 2016
Brugada syndrome might stay undetected in patients until surviving cardiac arrest. Despite the prominent advances in exploring the disease in the past 2 decades, many questions remain unanswered and the controversies continue. Despite all mutations identified to be associated with the disease, two-thirds of cases have a negative genetic test.
Marwan M, Refaat +2 more
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Brugada syndrome might stay undetected in patients until surviving cardiac arrest. Despite the prominent advances in exploring the disease in the past 2 decades, many questions remain unanswered and the controversies continue. Despite all mutations identified to be associated with the disease, two-thirds of cases have a negative genetic test.
Marwan M, Refaat +2 more
openaire +2 more sources
Current Opinion in Cardiology, 2010
The Brugada syndrome has been investigated in depth since its description in 1992 both on a clinical and on a basic research level. Since the discovery of the first genetic defect in 1998, several genes have been subsequently identified. However, to date all these genes together explain only 30% of the cases, indicating that there is still an important
Oscar, Campuzano +2 more
openaire +2 more sources
The Brugada syndrome has been investigated in depth since its description in 1992 both on a clinical and on a basic research level. Since the discovery of the first genetic defect in 1998, several genes have been subsequently identified. However, to date all these genes together explain only 30% of the cases, indicating that there is still an important
Oscar, Campuzano +2 more
openaire +2 more sources
Cardiology in Review, 1999
In 1992, Brugada and Brugada reported a distinct subgroup of patients with episodes of "idiopathic"polymorphic ventricular tachycardia or ventricular fibrillation characterized by a unique electrocardiographic (ECG) pattern, which consisted of right bundle branch block and ST-segment elevation from V1 to V2-V3. As in patients with long QT syndrome, the
CORRADO, DOMENICO +4 more
openaire +3 more sources
In 1992, Brugada and Brugada reported a distinct subgroup of patients with episodes of "idiopathic"polymorphic ventricular tachycardia or ventricular fibrillation characterized by a unique electrocardiographic (ECG) pattern, which consisted of right bundle branch block and ST-segment elevation from V1 to V2-V3. As in patients with long QT syndrome, the
CORRADO, DOMENICO +4 more
openaire +3 more sources
Future Cardiology, 2013
More than 20 years have passed since the description of Brugada syndrome as a clinical entity. The original case series depicted patients who all had coved ST-segment elevation in the right precordial leads, associated with a high risk of sudden death and no apparent structural heart disease.
Anthony, Li, Elijah R, Behr
openaire +2 more sources
More than 20 years have passed since the description of Brugada syndrome as a clinical entity. The original case series depicted patients who all had coved ST-segment elevation in the right precordial leads, associated with a high risk of sudden death and no apparent structural heart disease.
Anthony, Li, Elijah R, Behr
openaire +2 more sources