Results 281 to 290 of about 636,478 (335)

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson   +8 more
wiley   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

open access: yesAnnals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang   +10 more
wiley   +1 more source

USH2A-Mutated Human Retinal Organoids Model Rod-Cone Dystrophy. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Ashworth KE   +4 more
europepmc   +1 more source

Design and experiment of a novel intelligent device suitable for automation vegetable plug seedling. [PDF]

open access: yesPLoS One
Haifei Q   +6 more
europepmc   +1 more source

Time‐Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε‐caprolactone)‐Poly(N,N′‐dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media

open access: yesAngewandte Chemie, EarlyView.
Synthesis of hydrolytically degradable poly(N,N′‐dimethylacrylamide)‐poly(ɛ‐caprolactone) nanoparticles via reverse sequence polymerization‐induced self‐assembly (PISA) at 80 °C is studied by time‐resolved small‐angle X‐ray scattering (SAXS). This technique reveals the formation of molten poly(ɛ‐caprolactone) (PCL) droplets prior to water addition, a ...
Matthew A. H. Farmer   +4 more
wiley   +1 more source

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