Results 221 to 230 of about 210,095 (352)

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

open access: yesAnnals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang   +10 more
wiley   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

open access: yesAdvanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna   +9 more
wiley   +1 more source

Discovery and Validation of Molecular Biomarkers for Differentiation of Nondysplastic Barrett's Esophagus from High-grade Dysplasia and Esophageal Adenocarcinoma. [PDF]

open access: yesCancer Prev Res (Phila)
Matchett CL   +22 more
europepmc   +1 more source

Adhesion of Helicobacter pylori to polarized T84 human intestinal cell monolayers induces a reorganization of the brush border and is PH dependent

open access: bronze, 1995
I. Corthésy‐Theulaz   +7 more
openalex   +1 more source

USH2A-Mutated Human Retinal Organoids Model Rod-Cone Dystrophy. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Ashworth KE   +4 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy