Results 41 to 50 of about 210,095 (352)

Injectable hydrogels of newly designed brush biopolymers as sustained drug-delivery vehicle for melanoma treatment

open access: yesSignal Transduction and Targeted Therapy, 2021
Novel biocompatible and brush copolymers have been developed for cancer treatment using its controlled drug-release potential. Polyurethane graft on linear dextrin has been synthesized to control the hydrophilic–hydrophobic balance for regulated drug ...
Aparna Shukla   +2 more
doaj   +1 more source

Perineuronal nets restrict transport near the neuron surface: A coarse-grained molecular dynamics study

open access: yesFrontiers in Computational Neuroscience, 2022
Perineuronal nets (PNNs) are mesh-like extracellular matrix structures that wrap around certain neurons in the central nervous system. They are hypothesized to stabilize memories in the brain and act as a barrier between cell and extracellular space.
Kine Ødegård Hanssen   +1 more
doaj   +1 more source

Confinement of two-dimensional rods in slit pores and square cavities

open access: yes, 2015
Using Monte Carlo simulation, we analyse the behaviour of two-dimensional hard rods in four different types of geometric confinement: (i) a slit pore where the particles are confined between two parallel walls with homeotropic anchoring; (ii) a hybrid ...
Geigenfeind, Thomas   +3 more
core   +1 more source

Histopathological effects of cypermethrin and Bacillus thuringiensis var. israelensis on midgut of Chironomus calligraphus larvae (Diptera: Chironomidae) [PDF]

open access: yes, 2018
Pesticides are extensively used for the control of agricultural pests and disease vectors, but they also affect non-target organisms. Cypermethrin (CYP) is a synthetic pyrethroid used worldwide. Otherwise, bioinsecticides like Bacillus thuringiensis var.
Arrighetti, Florencia   +2 more
core   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao   +10 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron   +5 more
wiley   +1 more source

Clinical comparison of liquid-based and conventional cytology of oral brush biopsies: a randomized controlled trial

open access: yesHead & Face Medicine, 2018
Background Exfoliative cytology performed on oral brush samples can help dentists to decide, whether a given oral lesion is (pre-) malignant. The use of non-invasive brush biopsies as an auxiliary tool in the diagnosis of oral mucosal lesions has gained ...
Constanze Olms   +4 more
doaj   +1 more source

Factors Associated with Malignant Biliary Strictures in Patients with Atypical or Suspicious Cells on Brush Cytology [PDF]

open access: yesClinical Endoscopy, 2019
Background/Aims Pathological diagnosis of biliary strictures with atypical or suspicious cells on endoscopic retrograde brush cytology and indeterminate strictures on imaging is challenging.
Ji Young Park, Tae Joo Jeon
doaj   +1 more source

Utility of indigenous cytology technique in the diagnosis of oral cavity lesions using normal saline as a processing fluid: A comparative study

open access: yesJournal of Cytology, 2023
Background: Oral cancer is a major health problem in developing countries. Cytology has been widely accepted as a tool in the early diagnosis of cancer.
B N Kumarguru   +3 more
doaj   +1 more source

Evaluation of pressure-stiffness coupling in brush seals [PDF]

open access: yes, 2010
Brush seals are comprised of fine diameter fibers densely packed between retaining and backing plates. To achieve seal compliance bristles are arranged to contact rotor with some lay angle.
Aksit, Mahmut Faruk   +2 more
core   +1 more source

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