Results 211 to 220 of about 33,690 (269)
Delphi consensus: First‐line use of biologics and small molecules in hidradenitis suppurativa
Journal of the European Academy of Dermatology and Venereology, EarlyView.This Delphi Consensus study identified upgrade criteria for the use of biologics and small molecules as first‐line therapy in hidradenitis suppurativa (HS). European HS experts evaluated 16 clinical scenarios, voting on eligibility for therapy escalation.Georgios Nikolakis, Erkan Alpsoy, Florian Anzengruber, Matthias Augustin, Falk G. Bechara, Pierre‐André Becherel, Farida Benhadou, Vincenzo Bettoli, Joana Cabete, Raffaele Dante Caposiena Caro, Antonella Di Cesare, Giovanni Damiani, Valentina Dini, Evangelos J. Giamarellos‐Bourboulis, Krisztián Gáspár, Katalin Glasenhardt, Philippe Guillem, Ariela Hafner, Barbara Horvath, John R. Ingram, Vaiva Jarienè, Gregor B. E. Jemec, Alexander Katoulis, Natalia Kirsten, Georgios Kokolakis, Piotr K. Krajewski, Aikaterini I. Liakou, Flavia Manzo Margiotta, Angelo V. Marzano, Antonio Martorell, Lukasz Matusiak, Dillon Mintoff, Alejandro Molina Leyva, Andreas Pinter, Anna Pirogova, Maurizio Podda, Francesca Prignano, Jorge Romani, Marco Romanelli, Elia Rosi, Samed Sahin, Ditte M. L. Saunte, Sylke Schneider‐Burrus, Mariano Suppa, Jacek Szepietowski, Andrea Szegedi, Simon Francis Thomsen, Thrasyvoulos Tzellos, Anastasia Trigoni, Hessel H. Van Der Zee, Kelsey Van Straalen, Skaidra Valiukevičiene, Eva Vilarrasa, Esther von Stebut, Christos C. Zouboulis +54 morewiley +1 more sourceA family of NADPH/NADP<sup>+</sup> biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes. [PDF]
Nat CommunScherschel M, Niemeier JO, Jacobs LJHC, Hoffmann MDA, Diederich A, Bell C, Höhne P, Raetz S, Kroll JB, Steinbeck J, Lichtenauer S, Multhoff J, Zimmermann J, Sadhanasatish T, Rothemann RA, Grashoff C, Messens J, Ampofo E, Laschke MW, Riemer J, Roma LP, Schwarzländer M, Morgan B. +22 moreeuropepmc +1 more sourceBimekizumab efficacy using IHS4 outcomes in hidradenitis suppurativa: Results from BE HEARD I and II
Journal of the European Academy of Dermatology and Venereology, EarlyView.The majority of bimekizumab‐treated patients shifted from severe to mild and moderate IHS4 stages, and nearly 25% achieved an IHS4 of 0 by Week 48. Bimekizumab led to clinically meaningful improvements across IHS4 outcome measures. These data highlight an opportunity to address the need for effective treatments against draining tunnels.Thrasyvoulos Tzellos, Evangelos J. Giamarellos‐Bourboulis, Kelsey R. van Straalen, Antonio Martorell, Brian Kirby, Afsaneh Alavi, Koremasa Hayama, Saakshi Khattri, Wayne Gulliver, Christopher J. Sayed, Leah Davis, Robert L. Rolleri, Christina Crater, Ingrid Pansar, Jérémy Lambert, Christos C. Zouboulis +15 morewiley +1 more sourceMolecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function. [PDF]
Nat CommunCsoma N, Machin JM, Whitehouse JM, Rodrìguez-Alonso R, Olejnik M, Cahill AK, Cho SH, Schäberle TF, Iorga BI, Ranson NA, Radford SE, Calabrese AN, Collet JF. +12 moreeuropepmc +1 more sourceFrequency of arboreality is correlated with longer hand skeletons in Gorilla: Analysis of a new skeletal sample of Bwindi mountain gorillas
Journal of Anatomy, EarlyView.Variation in arboreality across gorilla populations is associated with systematic differences in manual digital lengths. Using a new dataset of linear metrics from the Bwindi mountain gorillas, we quantify metacarpal and phalangeal lengths in eastern and western gorilla populations across all five rays. Consistent with quantified behavioral differences,Elliot G. Greiner, Christopher B. Ruff, Charlotte King, Aventino Nkwasibwe, Thadee Muhire, Emmanuel Tibenda, Jason S. Massey, Juho‐Antti Junno, Rowan M. Sherwood, Jean Bosco Noheri, Fred Nizeyimana, Tierra Smiley Evans, Richard Muvunyi, Dennis Babaasa, Martha M. Robbins, Shannon C. McFarlin, Tracy L. Kivell +16 morewiley +1 more source“Design principles of a membrane-spanning ubiquitin ligase”
Williams C, Nocka LM, Hedger G, Parashara P, Pardon E, Latorraca NR, Pusapati GV, Lartey D, Gao L, Milenkovic L, Chalk R, Steyaert J, Marqusee S, Carrique L, Bazan JF, Rouse SL, Kong JH, Siebold C, Rohatgi R. +18 moreeuropepmc +1 more sourceMetabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers. [PDF]
Breast Cancer ResDerouane F, Desgres M, Moroni C, Ambroise J, Berlière M, Van Bockstal MR, Galant C, van Marcke C, Vara-Messler M, Hutten SJ, Jonkers J, Mourao L, Scheele CLGJ, Duhoux FP, Corbet C. +14 moreeuropepmc +1 more source
