Results 51 to 60 of about 37,617 (261)

The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities [PDF]

, 2018
O-Linked GlcNAc transferase (OGT) possesses dual glycosyltransferase-protease activities. OGT thereby stably glycosylates serines and threonines of numerous proteins and, via a transient glutamate glycosylation, cleaves a single known substrate-the so ...
Borodkin, Vladimir S., Herr, Winship, Kapuria, Vaibhav, Lammers, Fabienne, Röhrig, Ute F., van Aalten, Daan M. F., Waridel, Patrice, Zoete, Vincent   +7 more
core   +4 more sources

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

"100 per cent, Body and Soul”:The Ability of an Agent to Act for a Competitor of his Principal [PDF]

, 2013
No abstract ...
Chalmers, J., Leverick, F.
core   +2 more sources

The impacts of biological invasions

Biological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source

Ten years of application of the Brussels II bis regulation

, 2015
Regulation Brussels II bis entered into force on 1 August 2004 but its application has began on March 1, 2005. Ten years of its application by the courts of the Member States gave rise to the interpretation of its provisions as evidenced by requests for ...
Bernadet Bordaš
semanticscholar   +1 more source

Barriers and Enablers of Circular Economy in Electrical and Electronic Equipment: A Systematic Literature Review

Business Strategy and the Environment, EarlyView.
ABSTRACT Rapid technological change, shorter lifecycles and rising demand for electrical and electronic equipment (EEE) are increasing waste electrical and electronic equipment (WEEE) and emphasise the need for a circular economy. This paper identifies barriers and enablers of the circular transition in EEE and outlines interventions.
Aya Abdelmeguid, Lucia Corsini
wiley   +1 more source

The Impact of Freedom of Speech on Conspiracy Beliefs

European Journal of Social Psychology, EarlyView.
ABSTRACT Conspiracy beliefs are often portrayed as a threat to democracies. However, less is known about the extent to which the state of democracy may affect conspiracy beliefs. Hence, we investigated the impact of the societal level of freedom of speech on conspiracy beliefs. In Study 1, using aggregated nation‐level data (N = 68 countries), we found
Paul Bertin, Elisa Tognon, Kenzo Nera, Rrita Bajraktari, Pit Klein, Vincent Yzerbyt, Olivier Klein   +6 more
wiley   +1 more source

The Role of European Union (EU) Metagovernance in Supporting the Voluntary and Community Sector in Northern Ireland

European Policy Analysis, EarlyView.
ABSTRACT This article argues that European Union (EU) peacebuilding scholarship can benefit from organizational research on the socio‐spatial dynamics of policy implementation. It introduces a strategic‐relational heuristic to address two key gaps: the marginalization of grassroots agency in spatial analyses and the separation of strategy from ...
Giada Lagana, Sioned Pearce
wiley   +1 more source

Brussels I bis Regulation and Special Rules: Opportunities to Enhance Judicial Cooperation

, 2021
The Volume collects the results of the EU co-funded Project Enhancing Enforcement under Brussels Ia – EN2BRIa, European Union Justice Programme 2014-2020, JUST-JCOO-AG-2018 JUST 831598. It critically and thoroughly addresses art. 67 Brussels I bis Regulation, which determines the relationships between the Regulation and other EU law instruments ...
Ilaria Queirolo, Rosario Espinosa Calabuig, Giulio Cesare Giorgini, Nada Dollani, Chiara E Tuo, Laura Carpaneto, Stefano Dominelli   +6 more
openaire   +1 more source

EU Policy‐Making in the Digital Age: Major Trends and Insights From Public Policy Research

European Policy Analysis, EarlyView.
ABSTRACT Has digitalization changed policy‐making dynamics at the European Union (EU) level? To investigate this issue, this article presents a scoping review of the literature on EU digital policy‐making. While much scholarship adopts a ‘Governance’ approach, two conceptually rich strands emerge: critical approaches, and digital sovereignty.
Chloé Bérut
wiley   +1 more source