Results 91 to 100 of about 5,288 (183)

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages [PDF]

, 2006
BACKGROUND: Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Olsson, Sandra, Sundler, Roger
core   +3 more sources

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 422-444, February 2026.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL) [PDF]

, 2017
Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the ...
Rajakaruna, A., Rajakaruna, A.
core  

Incidence, Prevalence, Survival and Mortality of Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma and Waldenström Macroglobulinaemia in Australia

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Mature B‐cell neoplasms chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) and waldenström macroglobulinaemia (WM) are highly prevalent in older populations. Aims This study quantified the incidence, prevalence and relative survival/mortality rate in Australia for CLL/SS and WM and reported the past trends. Materials
Dieu Nguyen, Shalika Bohingamu Mudiyanselage, Dipti Talaulikar, Fei‐Li Zhao, Boxiong Tang, Mostafa Kamal, Lan Gao   +6 more
wiley   +1 more source

Génexpressziós profil vizsgálata a pajzsmirigy hámeredetű tumoraiban = Gene-expression profiles in the thyroid tumors of epithelial origin [PDF]

, 2007
A thyroid tumorok kialakulása az epitelialis carcinogenezis többlépcsős modelljeként irható le. Tumor szuppresszor gének, és az onkogének három fő csoportjába tartozó gének (GTP-kötő protein, sejtmagi transzkripciós faktor, tirozin kináz) mutációinak ...
Ember, István, Juhász, Ferenc, Várkondi, Edit   +2 more
core  

Overcoming challenges in CAR‐T therapy for malignancies: Mechanisms and strategies

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Chimeric antigen receptor T (CAR‐T) cell therapy faces three major challenges: tumour‐intrinsic resistance mechanisms, limitations in CAR‐T cell efficacy and immunosuppressive tumour microenvironment (TME) effects. Emerging strategies address these hurdles through precision targeting enhancement, optimised CAR‐T cell persistence/functionality and TME ...
Yushan Huang, Jun Long, Changpeng Yang, Wang Lu, Husheng Mei, Wenbin Qian, Jing Yang, Aibin Liang   +7 more
wiley   +1 more source

Ibrutinib and Neurolisteriosis: Simple Coincidence?

Annals of Internal Medicine: Clinical Cases
Listeria monocytogenes is an opportunistic food-borne pathogen that can cross the blood–brain barrier and infect the central nervous system, causing potentially life-threatening neurolisteriosis, including brain abscess.
Paul Dalmas, Coline Mortier, Margaux Froidefond, Barbara Doudier, Pierre Dudouet, Aude Collignon, Mikael Ebbo, Jean-Christophe Lagier, Nadim Cassir   +8 more
doaj   +1 more source

MIF-induced stromal PKCβ/IL8 is essential in human acute myeloid leukemia [PDF]

, 2017
Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue microenvironment plays a critical role in promoting AML cell survival.
Amina M. Abdul-Aziz, Brenner, Denizot, Falantes, Federica Di Palma, Fu, Gao, Huang, Inoue, Ioannou, Kristian M. Bowles, Linenberger, Manar S. Shafat, Matthew J. Lawes, Nomellini, Park, Reikvam, Reikvam, Reuss-Borst, Rushworth, Stuart A. Rushworth, Tarang K. Mehta, Tobler, Zaitseva   +23 more
core   +2 more sources

Alterations in Gut Microbiota and Metabolic Profiles in Relapsed or Refractory Lymphoma

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Metabolomic volcano‐heatmap reveals seven upregulated metabolites in relapsed/refractory lymphoma, underscoring gut metabolic reprogramming as a potential therapeutic target. ABSTRACT To identify potential therapeutic strategies for relapsed or refractory lymphoma (R/RL) by examining differences in gut microbiota composition and metabolic profiles ...
Yu‐Ying Guo, Kang‐Jing Xue, Liao Wang, Gang‐Gang Wang, Ting‐Ting Zhang, Shu‐Ling Hou   +5 more
wiley   +1 more source

Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis [PDF]

, 2014
Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent reactive oxygen species as ...
Blanchard, Catlyn, Hattori, Hidenori, Jia, Yonghui, Jo, Hakryul, Kasorn, Anongnard, Li, Yitang, Loison, Fabien, Luo, Hongbo, McDonald, Douglas Ray, Pai, Sung-Yun, Porter, Timothy F., Sakai, Jiro, Sarraj, Bara, Serhan, Charles Nicholas, Subramanian, Kulandayan K., Zirkle, Dorothy   +15 more
core   +1 more source