Results 1 to 10 of about 21,847 (205)
Recent Advances in BTK Inhibitors for the Treatment of Inflammatory and Autoimmune Diseases
Molecules, 2021 Bruton’s tyrosine kinase (BTK) plays a crucial role in B-cell receptor and Fc receptor signaling pathways. BTK is also involved in the regulation of Toll-like receptors and chemokine receptors.
Datong Zhang, Fancui Meng
exaly +3 more sources
The Immunomodulatory Functions of BTK Inhibition in the Central Nervous System
Journal of Inflammation Research, 2022 Tingyu Cao,1 Zengguang Wang,2 Xiaodong Zhu1 1Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Department of Neurosurgery, Tianjin Neurological Institute, Tianjin ...
Zengguang Wang, Tingyu Cao, Xiaodong Zhu
exaly +2 more sources
Targeting Bruton's Tyrosine Kinase in CLL: Selectivity, Resistance Mechanisms, and Emerging Therapeutic Strategies. [PDF]
CellsKinases are highly explored drug targets due to their central role in cell growth, differentiation, and cell death, as well as their relationship to cancer initiation and progression.
Bravo E +4 more
europepmc +2 more sources
Cancer Biology & Medicine, 2022 Objective: B-cell antigen receptor (BCR) signaling is required to maintain the physiological functions of normal B cells and plays an important pathogenic role in B-cell malignancies. Bruton tyrosine kinase (BTK), a critical mediator of BCR signaling, is
Liao Wang +7 more
doaj +1 more source
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Platelets, 2021 Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi +4 more
doaj +1 more source
Megjegyzések a lokális Craig interpolációhoz
Elpis, 2022 Zalán Molnár, Övge Öztürk
doaj +1 more source
Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia.
Tony Eight Lin +10 more
doaj +1 more source
Metszetek, 2022 Az elmúlt évtizedekben egyre nagyobb figyelmet kap a környezeti problémák és az ezzel ös - szefüggő társadalmi jelenségek vizsgálata. Az egyetemi hallgatók környezettudatosságának és környezettudatosságukat befolyásoló tényezőknek a megismerése ...
Ferenc Mónus +2 more
doaj +1 more source
Exploration of Targeted Anti-tumor Therapy, 2020 Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell receptor signaling and the irreversible BTK inhibitor ...
Rachael Arthur +3 more
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Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
eLife, 2023 The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec homology (PH-TH) module connected by a proline-rich linker to a ‘Src module’, an SH3-SH2-kinase unit also found in Src-family kinases and Abl. We showed previously that Btk is
Laura M Nocka +4 more
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