Results 21 to 30 of about 21,847 (205)

Amplifying Btk's Signal [PDF]

Immunity, 2003
The Tec kinase Btk is an important regulator of antigen receptor activation of phospholipase C-gamma (PLC-gamma). Data from Carpenter and colleagues (Saito et al., this issue of Immunity) now suggest that Btk also activates phosphatidylinositol-4-phosphate 5-kinase (PIP5K), thereby stimulating a positive feedback loop that generates PI(4,5)P2, the ...
openaire   +2 more sources

Bruton’s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response

Cell Death and Disease, 2021
Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) is known to manifest high prevalence of intestinal disorders including IBD. Although BTK mediates the
Di Guan, Zixi Wang, Jianxin Huo, Shengli Xu, Kong-Peng Lam   +4 more
doaj   +1 more source

Bruton’s Tyrosine Kinase and Its Isoforms in Cancer

Frontiers in Cell and Developmental Biology, 2021
Bruton’s tyrosine kinase (BTK) is a soluble tyrosine kinase with central roles in the development, maturation, and signaling of B cells. BTK has been found to regulate cell proliferation, survival, and migration in various B-cell malignancies.
Xianhui Wang, Leila Kokabee, Mostafa Kokabee, Douglas S. Conklin   +3 more
doaj   +1 more source

Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies

Frontiers in Cell and Developmental Biology, 2021
Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR).
Stefan F. H. Neys, Rudi W. Hendriks, Odilia B. J. Corneth   +2 more
doaj   +1 more source

Btk inhibitors in atherosclerosis [PDF]

Blood, 2018
In this issue of Blood, Busygina et al provide provocative evidence that there is a potential role for Bruton tyrosine kinase (Btk) inhibitors in inhibiting platelet aggregation specifically at the site of unstable atherosclerotic plaques ...
openaire   +2 more sources

A vajdasági/délvidéki magyarok nemzeti identitása 1990-től napjainkig – II.

Metszetek, 2019
Tanulmányunk második részében bemutatjuk a vajdasági/délvidéki magyarok harmadik generációjának, az 1990 után színre lépettek nemzeti identitásának politikai-állampolgári és kulturális-történeti összetevőinek átalakulási folyamatait.
Teréz Kovács, Igor Kiss
doaj   +1 more source

Bruton Tyrosine Kinase Inhibition and Its Role as an Emerging Treatment in Pemphigus

Frontiers in Medicine, 2021
Bruton Tyrosine Kinase (BTK) has a key role in multiple pathways involved in inflammation and autoimmunity. Therefore, BTK has become a new therapeutic target for a group of hematologic and autoimmune disorders.
Aikaterini Patsatsi, Dedee F. Murrell
doaj   +1 more source

A Comprehensive Review of Small-Molecule Inhibitors Targeting Bruton Tyrosine Kinase: Synthetic Approaches and Clinical Applications

Molecules, 2023
Bruton tyrosine kinase (BTK) is an essential enzyme in the signaling pathway of the B-cell receptor (BCR) and is vital for the growth and activation of B-cells.
Qi Zhang, Changming Wen, Lijie Zhao, Yatao Wang   +3 more
doaj   +1 more source

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Frontiers in Immunology, 2021
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of ...
Alexander P. de Porto, Zhe Liu, Zhe Liu, Regina de Beer, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll, Tom van der Poll, Alex F. de Vos, Alex F. de Vos   +16 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source