Results 41 to 50 of about 78,184 (307)
Resisting the Resistance: Navigating BTK Mutations in Chronic Lymphocytic Leukemia (CLL)
Genes, 2023 Bruton’s tyrosine kinase (BTK) plays a key role in the B-cell receptor (BCR) signaling pathway and confers anti-apoptotic and proliferative properties to malignant B-cells in chronic lymphocytic leukemia (CLL). Small molecule BTK inhibitors were designed
Alexandra Chirino +3 more
semanticscholar +1 more source
Blood Advances, 2023 Key Points • Molecular profiling of MZL may assist in the rational use of BTK inhibitor therapy.• BTK and PLCG2 mutations confer acquired resistance of MZL to BTK inhibition.
M. Tatarczuch +13 more
semanticscholar +1 more source
Recent Advances in BTK Inhibitors for the Treatment of Inflammatory and Autoimmune Diseases
Molecules, 2021 Bruton’s tyrosine kinase (BTK) plays a crucial role in B-cell receptor and Fc receptor signaling pathways. BTK is also involved in the regulation of Toll-like receptors and chemokine receptors.
Datong Zhang, He Gong, Fancui Meng
doaj +1 more source
Pharmaceuticals, 2023 Bruton’s tyrosine kinase (BTK) is a critical component in B-cell receptor (BCR) signaling and is also expressed in haematogenic and innate immune cells. Inhibition of BTK hyperactivity is implicated in B-cell malignancies and autoimmune diseases.
Asim Najmi +8 more
doaj +1 more source
Blood Advances, 2022 Key Points • BCR signaling is inhibited by pirtobrutinib in vitro and in vivo regardless of BTK C481S mutation but is reactivated in vivo at progression.• BTK mutations at the gatekeeper site T474 and second-site kinase-dead mutations lead to resistance ...
A. Naeem +24 more
semanticscholar +1 more source
Bruton’s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response
Cell Death and Disease, 2021 Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) is known to manifest high prevalence of intestinal disorders including IBD. Although BTK mediates the
Di Guan +4 more
doaj +1 more source
Bruton’s Tyrosine Kinase and Its Isoforms in Cancer
Frontiers in Cell and Developmental Biology, 2021 Bruton’s tyrosine kinase (BTK) is a soluble tyrosine kinase with central roles in the development, maturation, and signaling of B cells. BTK has been found to regulate cell proliferation, survival, and migration in various B-cell malignancies.
Xianhui Wang +3 more
doaj +1 more source
Btk inhibitors in atherosclerosis [PDF]
Blood, 2018 In this issue of Blood, Busygina et al provide provocative evidence that there is a potential role for Bruton tyrosine kinase (Btk) inhibitors in inhibiting platelet aggregation specifically at the site of unstable atherosclerotic plaques ...
openaire +2 more sources
Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies
Frontiers in Cell and Developmental Biology, 2021 Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR).
Stefan F. H. Neys +2 more
doaj +1 more source
Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia.
New England Journal of Medicine, 2022 BACKGROUND Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means of dual mechanisms of action: decreased macrophage (Fcγ receptor)-mediated ...
D. Kuter +28 more
semanticscholar +1 more source