Results 41 to 50 of about 21,847 (205)

Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.

PLoS Pathogens, 2013
Phagocytosis of the opportunistic fungal pathogen Candida albicans by cells of the innate immune system is vital to prevent infection. Dectin-1 is the major phagocytic receptor involved in anti-fungal immunity. We identify two new interacting proteins of
Karin Strijbis, Fikadu G Tafesse, Gregory D Fairn, Martin D Witte, Stephanie K Dougan, Nicki Watson, Eric Spooner, Alexandre Esteban, Valmik K Vyas, Gerald R Fink, Sergio Grinstein, Hidde L Ploegh   +11 more
doaj   +1 more source

Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells

Frontiers in Pharmacology, 2022
Despite recent improvements in multiple myeloma (MM) treatment, MM remains an incurable disease and most patients experience a relapse. The major reason for myeloma recurrence is the persistent stem cell-like population.
Weam Othman Elbezanti, Weam Othman Elbezanti, Omar S. Al-Odat, Omar S. Al-Odat, Robert Chitren, Robert Chitren, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Krishne Gowda, Shantu Amin, Gavin P. Robertson, Venkatesh V. Nemmara, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey   +14 more
doaj   +1 more source

Preclinical Serial Assessment of Virtual Physiology After Implantation of a Novel Endoluminal Resorbable Fibrillated Scaffold

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The resorbable fibrillated scaffold (RFS) is a novel electrospun, polylactide‐based endoluminal scaffold developed for peripheral arterial applications. Its porous microfibre architecture is intended to support host cell infiltration and vascular restoration.
Kotaro Miyashita, Lucas Hatzikostas, Emiliano Bianchini, Milosz Dziarmaga, Chun‐Ting Shih, Jouke Dijkstra, Eric K. W. Poon, Bart Sanders, Golo von Basum, Rick de Vries, Kim van Noort, Marc van Sambeek, Jos C. van den Berg, Albert Chinhenzva, Scot Garg, Yoshinobu Onuma, Patrick W. Serruys   +16 more
wiley   +1 more source

Trends in adherence with a home blood pressure monitoring intervention among pregnant women in Ghana: A prospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study evaluates trends in adherence with home blood pressure (BP) monitoring in a cohort of Ghanaian pregnant women. Methods In this prospective cohort study, participants were pregnant women receiving antenatal care at a tertiary hospital in Ghana.
Emma R. Lawrence, Perez Sepenu, Betty A. Nartey, Clara Buxton, Andrea Pangori, Roxanne F. Harfmann, Sarah Compton, Titus K. Beyuo, Cheryl A. Moyer, Jody R. Lori, Samuel A. Oppong   +10 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Immunomodulating effects of antitumor drugs Bruton tyrosine kinase inhibitors and the possibility of their use in allergic and infectious diseases

Медицинская иммунология, 2023
Bruton's tyrosine kinase (BTK) inhibitors represent a class of drugs that have demonstrated their efficacy and safety in patients with chronic lymphocytic leukemia and non-Hodgkin's lymphomas who were considered refractory to any previously used type of ...
Yu. S. Torshina, N. B. Serebryanaya, T. V. Glazanova, M. A. Mikhalyova, S. V. Voloshin   +4 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Quantitative Systems Pharmacology Model to Predict Target Occupancy by Bruton Tyrosine Kinase Inhibitors in Patients With B‐Cell Malignancies

CPT: Pharmacometrics & Systems Pharmacology
The effectiveness of Bruton tyrosine kinase (BTK) inhibitors is influenced by the level of BTK occupancy in target tissues. In randomized phase 3 studies, progression‐free survival (PFS) with zanubrutinib was superior to ibrutinib, whereas acalabrutinib ...
Oleg Demin Jr, Ying Ou, Galina Kolesova, Dmitry Shchelokov, Alexander Stepanov, Veronika Musatova, Sri Sahasranaman, Yating Zhao, Xiangyu Liu, Zhiyu Tang, William D. Hanley   +10 more
doaj   +1 more source

Az identitás és a társas normák szerepe a videójáték-felhasználók motivációinak hátterében

In Medias Res, 2021
A világon több száz millió ember játszik online vagy offline videójátékokkal. Fontos tisztázni, hogy kiket nevezünk videójátékosnak, gamernek. Egyes megközelítések szerint minden olyan személy, aki videójátékokkal játszik, gamernek mondható.
Tamás Győri, Balázs Jagodics
doaj   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source