Results 61 to 70 of about 78,184 (307)

Bruton Tyrosine Kinase Inhibition and Its Role as an Emerging Treatment in Pemphigus

Frontiers in Medicine, 2021
Bruton Tyrosine Kinase (BTK) has a key role in multiple pathways involved in inflammation and autoimmunity. Therefore, BTK has become a new therapeutic target for a group of hematologic and autoimmune disorders.
Aikaterini Patsatsi, Dedee F. Murrell
doaj   +1 more source

Investigation of the superconducting energy gap in the compound LuNi$_{2}$B$_{2}$C by the method of point contact spectroscopy: two-gap approximation [PDF]

, 2005
It is shown that the two-gap approximation is applicable for describing the $dV/dI(V)$ spectra of LuNi$_{2}$B$_{2}$C-Ag point contacts in a wide interval of temperatures.
Beloborod'ko, S. I., Bobrov, N. L., Chernobay, V. N., Naugle, D. G., Rathnayaka, K. D. D., Tyutrina, L. V., Yanson, I. K.   +6 more
core   +2 more sources

Inverting the BTK-BCL2 order [PDF]

Blood, 2020
In this issue of Blood, Lin et al report the first long-term follow-up data showing that Bruton tyrosine kinase inhibitors (BTKi's) are effective in chronic lymphocytic leukemia (CLL) after previous progression on venetoclax.
openaire   +2 more sources

BTK Inhibitors in Chronic Lymphocytic Leukemia: Biological Activity and Immune Effects

Frontiers in Immunology, 2021
Bruton´s tyrosine kinase (BTK) inhibitor (BTKi)s block the B-cell receptor (BCR) signaling cascade by binding to the BTK enzyme preventing the proliferation and survival of malignant and normal B cells.
M. Palma, T. Mulder, A. Österborg
semanticscholar   +1 more source

Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation

eJHaem, 2022
Inactivating mutations in Bruton's tyrosine kinase (BTK) in patients with follicular lymphoma (FL) have recently been reported. These mutations were found in BTK inhibitor‐treatment naïve patients.
Lone Schejbel, Marie Fredslund Breinholt, Anne Ortved Gang, Torsten Holm Nielsen, Lars Møller Pedersen, Estrid Høgdall, Peter Nørgaard   +6 more
doaj   +1 more source

Targeting BTK in B Cell Malignancies: From Mode of Action to Resistance Mechanisms

International Journal of Molecular Sciences
The B cell receptor (BCR) signaling pathway plays a crucial role in B cell development and contributes to the pathogenesis of B cell neoplasms. In B cell malignancies, the BCR is constitutively active through both ligand-dependent and ligand-independent ...
S. Mouhssine, Nawar Maher, B. Matti, A. Alwan, G. Gaidano   +4 more
semanticscholar   +1 more source

The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection.

PLoS ONE, 2013
In this study we investigated the role of Bruton's tyrosine kinase (Btk) in the immune response to the Gram-positive intracellular bacterium Listeria monocytogenes (Lm).
Afitap Derya Köprülü, Renate Kastner, Sebastian Wienerroither, Caroline Lassnig, Eva Maria Putz, Eva Maria Putz, Olivia Majer, Benjamin Reutterer, Veronika Sexl, Karl Kuchler, Mathias Müller, Thomas Decker, Wilfried Ellmeier   +12 more
doaj   +1 more source

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Frontiers in Immunology, 2021
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of ...
Alexander P. de Porto, Zhe Liu, Zhe Liu, Regina de Beer, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll, Tom van der Poll, Alex F. de Vos, Alex F. de Vos   +16 more
doaj   +1 more source

Theory of electron transport in normal metal/superconductor junctions [PDF]

, 2000
On the basis of the Keldysh method of non-equilibrium systems, we develop a theory of electron tunneling in normal-metal/superconductor junctions. By using the tunneling Hamiltonian model (being appropriate for the tight-binding systems), the tunneling ...
Hu, Chia-Ren, Yan, Xin-Zhong, Zhao, Hongwei   +2 more
core   +2 more sources

BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair

Acta Neuropathologica
In multiple sclerosis (MS), persisting disability can occur independent of relapse activity or development of new central nervous system (CNS) inflammatory lesions, termed chronic progression.
Anastasia Geladaris, Sebastian Torke, Darius Saberi, Y. B. Alankus, Frank Streit, Sabrina Zechel, C. Stadelmann-Nessler, Andreas Fischer, U. Boschert, Darius Häusler, Martin S. Weber   +10 more
semanticscholar   +1 more source