Results 71 to 80 of about 21,847 (205)
Клиническая онкогематологияИнгибиторы тирозинкиназы Брутона (BTK) коренным образом изменили подходы к лечению B-клеточных хронических лимфопролиферативных заболеваний (ЛПЗ), существенно улучшив показатели выживаемости и качество жизни пациентов.
Юлия Сергеевна Ефремова +2 more
doaj +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Entomologia Experimentalis et Applicata, EarlyView.The investigations evaluated the performance of the native parasitoid Exorista larvarum (L.) on last instar Cydalima perspectalis (Walker) larvae, using the factitious host Galleria mellonella (L.) as a control. Laboratory bioassays were conducted using no‐choice and choice (1:1 and 5:5) experimental designs.
Serena Gallizia +3 more
wiley +1 more source
Pirtobrutinib in Richter syndrome: Outcomes from the named patient programme in Italy
British Journal of Haematology, EarlyView.
Isacco Ferrarini +19 more
wiley +1 more source
Economic Burden of Chronic Lymphocytic Leukaemia in Australia
European Journal of Haematology, EarlyView.ABSTRACT Background The treatment landscape for chronic lymphocytic leukaemia (CLL) has transformed over the past decade. This study aimed to estimate the healthcare costs and health burden associated with CLL in Australia. Methods A Markov model was developed to simulate the lifetime healthcare costs and health outcomes associated with CLL in ...
Lan Gao +4 more
wiley +1 more source
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
eLifeFull-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core.
David Yin-wei Lin +5 more
doaj +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran +2 more
wiley +1 more source
Management of chronic urticaria: Current status and future prospect
Journal of the European Academy of Dermatology and Venereology, EarlyView.Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman +15 more
wiley +1 more source