Results 71 to 80 of about 78,184 (307)

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Mártonfi Ferenc halálának 30. évfordulójára

Távol-keleti Tanulmányok, 2022
Bartos Huba emlékezése Mártonfi Ferencre.
Huba Bartos
doaj   +1 more source

Mutation in Bruton Tyrosine Kinase (BTK) A428D confers resistance To BTK-degrader therapy in chronic lymphocytic leukemia

Leukemia
Targeting BTK has profoundly changed the face of CLL treatment over the past decade. Iterative advances in the cat and mouse game of resistance and redesign have moved BTK inhibitors from covalent to non-covalent and now targeted protein degraders ...
Richard L. Wong, Michael Y. Choi, Huan-You Wang, T. Kipps   +3 more
semanticscholar   +1 more source

Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells

Frontiers in Pharmacology, 2022
Despite recent improvements in multiple myeloma (MM) treatment, MM remains an incurable disease and most patients experience a relapse. The major reason for myeloma recurrence is the persistent stem cell-like population.
Weam Othman Elbezanti, Weam Othman Elbezanti, Omar S. Al-Odat, Omar S. Al-Odat, Robert Chitren, Robert Chitren, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Krishne Gowda, Shantu Amin, Gavin P. Robertson, Venkatesh V. Nemmara, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey   +14 more
doaj   +1 more source

BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis

Nature Communications
Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability accumulation in multiple sclerosis (MS) but has not been addressed therapeutically.
Ross Gruber, Gregory S Wirak, Anna S Blazier, Lan Lee, M. Dufault, Nellwyn Hagan, Nathalie Chretien, Michael LaMorte, Timothy R. Hammond, Agnes Cheong, Sean K. Ryan, Andrew Macklin, Mindy Zhang, Nilesh Pande, E. Havari, Timothy J. Turner, Anthony Chomyk, Emilie Christie, Bruce D. Trapp, D. Ofengeim   +19 more
semanticscholar   +1 more source

-----NRX-0492 Degrades Wildtype and C481 Mutant BTK and Demonstrates in vivo Activity in CLL Patient Derived Xenografts.

Blood, 2022
Bruton tyrosine kinase (BTK) is essential for B-cell receptor (BCR) signaling, a driver of chronic lymphocytic leukemia (CLL). Covalent inhibitors bind C481 in the active site of BTK and have become a preferred CLL therapy.
Deyi Zhang, Hailey M. Harris, Jonathan Chen, J. Judy, Gabriella James, Aileen M. Kelly, J. Mcintosh, A. Tenn-McClellan, Eileen Ambing, Ying Siow (May) Tan, Hao Lu, S. Gajewski, M. Clifton, Stephanie L. Yung, Daniel W. Robbins, Mehdi Piroozia, S. Skånland, E. Gaglione, Maissa Mhibik, Chingiz Underbayev, I. Ahn, Clare Sun, S. E. Herman, M. Noviski, A. Wiestner   +24 more
semanticscholar   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

BTK drives neutrophil activation for sterilizing antifungal immunity

Journal of Clinical Investigation
We describe a previously unappreciated role for Bruton’s tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used for treating B cell lymphoid malignancies.
Jigar V. Desai, Marissa A. Zarakas, Andrew L. Wishart, M. Roschewski, Mariano A. Aufiero, Ágnes Donkó, G. Wigerblad, Neta Shlezinger, Markus Plate, M. R. James, Jean K. Lim, G. Uzel, Jenna R. E. Bergerson, Ivan Fuss, Robert A. Cramer, Luis M Franco, Emily S. Clark, Wasif N Khan, Daisuke Yamanaka, Georgios Chamilos, J. El-Benna, Mariana J. Kaplan, Louis M. Staudt, Thomas L. Leto, Steven M. Holland, Wyndham H Wilson, Tobias M. Hohl, M. Lionakis   +27 more
semanticscholar   +1 more source

Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial

Clinical and Translational Science, 2021
Safe and effective new oral therapies for autoimmune, allergic, and inflammatory conditions remain a significant therapeutic need. Here, we investigate the human pharmacokinetics, pharmacodynamics (PDs), and safety of the selective, covalent Bruton’s ...
M. Kaul, P. End, M. Cabański, Carole Schuhler, A. Jakab, M. Kistowska, A. Kinhikar, Alessio Maiolica, Angela Sinn, R. Fuhr, B. Cenni   +10 more
semanticscholar   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source