Results 91 to 100 of about 78,184 (307)

Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer [PDF]

, 2004
X-linked agammaglobulinemia (XLA) is a human immunodeficiency caused by mutations in Bruton tyrosine kinase (Btk) and characterized by an arrest in early B-cell development, near absence of serum immunoglobulin, and recurrent bacteria infections.
Astrakhan, A., Chae, K., Ellmeier, W., Humblet, Stéphanie, Kato, R. M., Kipp, K., Rawlings, D. J., Tabuchi, R. S., Witte, O. N., Yu, P. W.   +9 more
core   +1 more source

Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models

Blood Advances, 2022
Key Points • Although the potency of BTK degradation by UBX-382 is remarkable, cereblon neosubstrates are degraded in a cell type–dependent manner.• UBX-382 can dramatically degrade resistance-associated mutations such as E41K, C481S/R/T/Y/F, and L528W ...
Ye Seul Lim, Sun-mi Yoo, V. Patil, H. Kim, Hyun-Hwi Kim, Beomseon Suh, Ji youn Park, Na-rae Jeong, Chi-Hoon Park, J. Ryu, Byung-Hoon Lee, P. Kim, Song Hee Lee   +12 more
semanticscholar   +1 more source

Radial capacity and hemodynamics evaluation in vitro and implantable feasibility validation in vivo of thinner bioresorbable polymer vascular stents

BMEMat, EarlyView.
A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen, Tao Li, Zhongyou Li, Jingyuan Zhou, Zhuo Zhang, Yan Xiong, Rifang Luo, Yu Chen, Yunbing Wang, Ping Fu   +9 more
wiley   +1 more source

Prolonged and tunable residence time using reversible covalent kinase inhibitors. [PDF]

, 2015
Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking.
Angelina Bisconte, Dane E. Karr, Danny Tam, David Finkle, David G. Loughhead, David M. Goldstein, Erik Verner, J. Hill, J. Michael Bradshaw, Jack Taunton, Jens Oliver Funk, Jesse M. Mcfarl, Jin Shu, Ken A. Brameld, Mary E, Philip A. Nunn, Principia Biopharma, Sergei Romanov, Timothy D. Owens, Tony Ton, Vaishali Patel, Vernon T. Phan, Ville O. Paavilainen, Xiaoyan Li   +23 more
core  

The role of critical current on point contact Andreev Reflection spectrum between a normal metal and a superconductor

, 2003
The point contact spectrum between a normal metal and a superconductor often shows unexpected sharp dips in the conductance at voltage values larger than the superconducting energy gap.
Mukhopadhyay, S., Raychaudhuri, P., Sheet, G.   +2 more
core   +1 more source

New means and challenges in the targeting of BTK.

Clinical Cancer Research
Bruton's tyrosine kinase (BTK) is central to the survival of malignant and normal B-lymphocytes and has been a crucial therapeutic target of several generations of kinase inhibitors and newly developed degraders.
Vindhya Nawaratne, Anya K. Sondhi, Omar Abdel-Wahab, Justin Taylor   +3 more
semanticscholar   +1 more source

BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining

Frontiers in Oncology, 2020
Tumor microenvironment (TME) plays a crucial role in the initiation and progression of lung adenocarcinoma (LUAD); however, there is still a challenge in understanding the dynamic modulation of the immune and stromal components in TME.
K. Bi, Xu-Ge Wei, Xiao-Xue Qin, Bo Li
semanticscholar   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, EarlyView.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

Clinical feasibility of endovascular recanalization with intravascular ultrasound-guided wiring for chronic total occlusion of below-the-knee arteries

CVIR Endovascular, 2023
Background Revascularization with endovascular therapy (EVT) for complex below-the-knee (BTK) chronic total occlusion (CTO) remains a challenging problem.
Naoki Hayakawa, Satoshi Kodera, Hiromi Miwa, Shinya Ichihara, Satoshi Hirano, Masataka Arakawa, Yasunori Inoguchi, Shunichi Kushida   +7 more
doaj   +1 more source

Phase 1 study of selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL.

Blood, 2019
Zanubrutinib is a potent and highly selective inhibitor of Bruton tyrosine kinase (BTK). In this first-in-human, open--label, multicenter, phase1 study, patients in part 1 (3+3) dose escalation) had relapsed/refractory B-cell malignancies and received ...
C. Tam, J. Trotman, Stephen Samuel Opat, J. Burger, G. Cull, D. Gottlieb, R. Harrup, P. Johnston, P. Marlton, J. Muñoz, J. Seymour, D. Simpson, A. Tedeschi, R. Elstrom, Yiling Yu, Zhiyu Tang, Lynn Han, Jane E. Huang, W. Novotny, Lai Wang, A. Roberts   +20 more
semanticscholar   +1 more source