Results 121 to 130 of about 114,702 (262)
The X Factor in Immunity: Sex Differences Shaped by the X Chromosome
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic +2 more
wiley +1 more source
Bruton’s tyrosine kinase inhibitors in brain diseases
Advanced NeurologyBruton’s tyrosine kinase (BTK) is a non-receptor-bound intracellular signaling protein. It is well known for its importance in the growth and malignancy of B cells, but recent studies suggested that the BTK is also associated with many other innate immune cells.
Hongying Hao, Qiang Liu, Han Jin
openaire +1 more source
Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas
Forum of Clinical Oncology, 2017 In normal B-cells, Bruton tyrosine kinase (Btk), a non-receptor tyrosine kinase involved in B-cell receptor (BCR) signalling, is essential for cell survival and maturation. Not surprisingly, Btk is also implicated in the pathogenesis of B-cell lymphomas,
Sklavenitis-Pistofidis R. +3 more
doaj +1 more source
Involvement of STAT3 in Bladder Smooth Muscle Hypertrophy Following Bladder Outlet Obstruction [PDF]
, 2006 We examined the involvement of the signal transducer and activator of transcription 3 (STAT3) in bladder outlet obstruction (BOO)-induced bladder smooth muscle hypertrophy using a rat in vivo and in vitro study.
Asanuma, Masato +5 more
core +1 more source
Polymethoxylated N‐Carboranyl Isoquinolinones: A New Scaffold for ABCG2 Inhibitors
ChemMedChem, Volume 21, Issue 3, 12 February 2026.Combinations of a boron‐based clusters (carborane) and polymethoxy group patterns are crucial to overcome ABCG2‐mediated multidrug resistance in cancer cells. (Created in BioRender. Kuhnert, L. (2025) https://BioRender.com/h4cnh5m). ABCG2‐mediated multidrug resistance (MDR) is a major challenge among chemotherapeutic treatments of colon, pancreatic ...
Lydia Kuhnert +5 more
wiley +1 more source
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. [PDF]
, 2012 Neutrophils trigger inflammation-induced acute kidney injury (AKI), a frequent and potentially lethal occurrence in humans. Molecular mechanisms underlying neutrophil recruitment to sites of inflammation have proved elusive. In this study, we demonstrate
Block, Helena +6 more
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Machine learning methods for predicting adverse drug events: A systematic review
British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 422-444, February 2026.Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo +8 more
wiley +1 more source
Incidence and management of toxicity associated with ibrutinib and idelalisib: a practical approach
Haematologica, 2017 The use of novel B-cell receptor signaling inhibitors results in high response rates and long progression-free survival in patients with indolent B-cell malignancies, such as chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma and ...
Iris de Weerdt +3 more
doaj +1 more source
Prolonged and tunable residence time using reversible covalent kinase inhibitors. [PDF]
, 2015 Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking.
Angelina Bisconte +23 more
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