Results 1 to 10 of about 114,065 (338)
Chronic lymphocytic leukaemia [PDF]
Nature Reviews Disease Primers, 2017 Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and lymphoid tissues. Signalling via surface immunoglobulin, which constitutes the major part of the B cell receptor, and several genetic alterations play a part in CLL pathogenesis ...
Stevenson, Freda +8 more
semanticscholar +13 more sources
PLoS ONE, 2020 Relapse of chronic lymphocytic leukaemia and non-Hodgkin's lymphoma after standard of care treatment is common and new therapies are needed. The targeted alpha therapy with 212Pb-NNV003 presented in this study combines cytotoxic α-particles from 212Pb ...
Astri Fjelde Maaland +6 more
doaj +2 more sources
Real-world disease characteristics and frontline treatments used in chronic lymphocytic leukaemia in Bulgaria: An observational cohort study (DESCRIBE) [PDF]
Journal of International Medical ResearchObjective Bruton tyrosine kinase inhibitors and B-cell lymphoma 2 inhibitors are currently the new standard active agents in chronic lymphocytic leukaemia. This observational study describes the real-world use of frontline treatment in Bulgarian patients
Vasko Graklanov +15 more
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Regularities of cytokine status changes in chronic lymphocytic leukaemia and their role in pathogenesis of progressive forms of disease [PDF]
Саратовский научно-медицинский журнал, 2012 The aim of the research is to study and to analyze results of investigations of cytokine blood profile in patients with B-cellular chronic lymphocytic leukaemia.
Shelekhova T.V. +2 more
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Nature Communications, 2017 Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with
Paul Yeh +25 more
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Nature Communications, 2017 Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune ...
Philip J. Law +96 more
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Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
Nature Communications, 2017 Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them ...
Claudia Minici +14 more
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Efficacy and Mechanism EvaluationBackground Chronic lymphocytic leukaemia is the most common leukaemia subtype and associated with profound immunosuppression. Bruton Tyrosine Kinase inhibitors have revolutionised chronic lymphocytic leukaemia management; however, Bruton Tyrosine Kinase ...
Jonathan A Cook +16 more
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Haematological Malignancy Presenting in an Unusual Manner [PDF]
Journal of Clinical and Diagnostic Research, 2022 Chronic lymphocytic leukaemia is a haematological malignancy that occurs due to an increased proliferation of mature B lymphocytes. It is considered to be the most common leukaemia in adults. Hyponatraemia is commonly seen in such patients.
Ponvijaya Muthuswamy Yadav +4 more
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Chronic Lymphocytic Leukaemia Unmasked by COVID-19 Infection: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2021 Corona Virus Disease 2019 (COVID-19) caused by SARS Cov-2 is an Ribonucleic Acid (RNA) virus which spreads through respiratory route. It was first detected in Wuhan, China in December 2019.
BHUMIKA GUPTA +4 more
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