Chronic lymphocytic leukaemia: An immunobiology approach [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 B cell chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia that follows an extremely variable clinical course. Several important prognostic parameters defining pathogenic and clinical subgroups of CLL have been identified and validated
Kostareli Efterpi +4 more
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Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells [PDF]
, 2013 Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid ...
Alison M. McCaig +14 more
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Human leukocyte antigens and genetic susceptibility to lymphoma [PDF]
, 2015 Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited susceptibility plays a role in the development of lymphoma, and the search for genetic risk factors has highlighted the contribution of the human leukocyte antigen (
Jarrett, R.F., McAulay, K.A.
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Társult tumorok előfordulása krónikus lymphoid leukaemiában | Occurrence of associated tumours in chronic lymphocytic leukemia [PDF]
, 2016 Absztrakt Bevezetés: A krónikus lymphoid leukaemia az egyik leggyakoribb hematológiai rosszindulatú kórkép. Célkitűzés: A 2000–2015 között diagnosztizált krónikus lymphoid leukaemiás betegek ...
Jakó, János +2 more
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Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
Nature Communications, 2021 The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with ...
Wei-Yu Lin +35 more
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A rare case of appendicular skeleton localization in a patient with chronic lymphocytic leukemia successfully treated with salvage radiation therapy [PDF]
, 2017 Bone involvements in chronic lymphocytic leukemia (CLL) are considered rare events, and the English-language medical literature describes them only in sporadic case reports. Consequently, robust indications for a rational clinical management are lacking.
Al Sayyad, Said +12 more
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Frontiers in HematologyBackgroundChronic Lymphocytic Leukaemia (CLL) is a slow-progressing condition often managed through active monitoring (“watch and wait”) strategies, which can lead to uncertainty for patients about prognosis, symptom management, and immunity-related ...
Kathryn Huntley +6 more
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The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil
Case Reports in Hematology, 2020 Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter’s syndrome. While Richter’s syndrome can present in untreated or relapsed-refractory cases, it may occur
Teng Fong Ng +4 more
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The Lancet OncologyBACKGROUND Most patients with chronic lymphocytic leukaemia progress after treatment or retreatment with targeted therapy or chemoimmunotherapy and have limited subsequent treatment options.
A. Kater +26 more
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Frontiers in HematologyBackgroundDisease-specific factors associated with decreased quality of life (QoL) in patients with leukemia have not been studied in a large-scale, global, observational study.MethodsThis cross-sectional study used the validated Hematological Malignancy
Sam Salek +12 more
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