Results 1 to 10 of about 67,656 (168)

Concurrent hepatic cirrhosis and chronic lymphocytic leukemia: a challenging coexistence: a case report [PDF]

Journal of Medical Case Reports
Background Chronic lymphocytic leukemia, a common B-cell malignancy in the elderly, is characterized by lymphocytosis, lymphadenopathy, and cytopenia.
Fatemeh Khodadadpour Mahani, Nazanin Zeinali Nezhad, Reza Ghaderi, Elham Jafari, Mana Khazaeli, Samaneh Omidi Kermanshahaninejad, Behrang Shamsinejad   +6 more
doaj   +2 more sources

Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia

Haematologica, 2018
Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1
Hana Plešingerová, Pavlína Janovská, Archana Mishra, Lucie Smyčková, Lucie Poppová, Antonín Libra, Karla Plevová, Petra Ovesná, Lenka Radová, Michael Doubek, Šárka Pavlová, Šárka Pospíšilová, Vítězslav Bryja   +12 more
doaj   +1 more source

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations

Haematologica, 2018
Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown.
Andreas Agathangelidis, Viktor Ljungström, Lydia Scarfò, Claudia Fazi, Maria Gounari, Tatjana Pandzic, Lesley-Ann Sutton, Kostas Stamatopoulos, Giovanni Tonon, Richard Rosenquist, Paolo Ghia   +10 more
doaj   +1 more source

SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

Haematologica, 2016
I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this disease.
Nili Dezorella, Ben-Zion Katz, Mika Shapiro, Aaron Polliack, Chava Perry, Yair Herishanu   +5 more
doaj   +1 more source

Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin’s lymphomas among relatives of patients with chronic lymphocytic leukemia

Haematologica, 2009
Background Previous studies have shown increased familial risk for chronic lymphocytic leukemia. In the most comprehensive study to date, we evaluated risk of chronic lymphocytic leukemia and lymphoproliferative disorders among first-degree relatives of ...
Lynn R. Goldin, Magnus Björkholm, Sigurdur Y. Kristinsson, Ingemar Turesson, Ola Landgren   +4 more
doaj   +1 more source

Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature

Journal of Medical Case Reports, 2018
Background Chronic lymphocytic leukemia and chronic myeloid leukemia are the most common types of adult leukemia. However, it is rare for the same patient to suffer from both.
Khadega A. Abuelgasim, Hinna Rehan, Maha Alsubaie, Nasser Al Atwi, Mohammed Al Balwi, Saeed Alshieban, Areej Almughairi   +6 more
doaj   +1 more source

Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome

Haematologica, 2018
Low-count monoclonal B-cell lymphocytosis is defined by the presence of very low numbers of circulating clonal B cells, usually phenotypically similar to chronic lymphocytic leukemia cells, whose biological and clinical significance remains elusive ...
Ignacio Criado, Arancha Rodríguez-Caballero, M. Laura Gutiérrez, Carlos E. Pedreira, Miguel Alcoceba, Wendy Nieto, Cristina Teodosio, Paloma Bárcena, Alfonso Romero, Paulino Fernández-Navarro, Marcos González, Julia Almeida, Alberto Orfao, The Primary Health Care Group of Salamanca for the Study of MBL   +13 more
doaj   +1 more source

Involvement of memory T-cells in the pathophysiology of chronic lymphocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2014
The role of T-cells in the pathogenesis of chronic lymphocytic leukemia has recently gained much attention due to the importance of the constant interaction between neoplastic B-cells with microenvironment substratum and T-cells.
Rodolfo Patussi Correia, Flavia Amoroso Matos e Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo P. Amarante-Mendes   +5 more
doaj   +1 more source

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

Haematologica, 2012
Background The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival and proliferation. Characterization of these signals and the pathways that propagate them
Francisco de Paula Careta, Stefania Gobessi, Rodrigo Alexandre Panepucci, Engin Bojnik, Fabio Morato de Oliveira, Daniel Mazza Matos, Roberto P. Falcão, Luca Laurenti, Marco A. Zago, Dimitar G. Efremov   +9 more
doaj   +1 more source

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

Haematologica, 2015
While the renal complications of plasma cell dyscrasia have been well-described, most information in patients with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis is derived from case reports. This is a retrospective analysis of patients
Paolo Strati, Samih H. Nasr, Nelson Leung, Curtis A. Hanson, Kari G. Chaffee, Susan M. Schwager, Sara J. Achenbach, Timothy G. Call, Sameer A. Parikh, Wei Ding, Neil E. Kay, Tait D. Shanafelt   +11 more
doaj   +1 more source