Results 1 to 10 of about 114,929 (186)

Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders [PDF]

Haematologica, 2014
Chronic antigen-stimulation has been recurrently involved in the earlier stages of monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia and other B-cell chronic lymphoproliferative disorders.
Ana Henriques, Arancha Rodríguez-Caballero, Ignacio Criado, Anton W. Langerak, Wendy G. Nieto, Quentin Lécrevisse, Marcos González, Emília Cortesão, Artur Paiva, Julia Almeida, Alberto Orfao   +10 more
doaj   +7 more sources

Successful long-term monotherapy with rituximab in a patient with chronic lymphocytic leukemia of the B-cell-lineage: a case report [PDF]

Journal of Medical Case Reports, 2008
Introduction Treatment of chronic lymphocytic leukemia of the B-cell-lineage is strongly based upon clinical staging because of the heterogeneous clinical course of this disease.
Sturm Isrid, Oertel Joachim, Oertel Stephan, Westermann Jörg, Pezzutto Antonio   +4 more
doaj   +5 more sources

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax [PDF]

Haematologica, 2017
Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Ana M. Cosialls, Helena Pomares, Daniel Iglesias-Serret, José Saura-Esteller, Sonia Núñez-Vázquez, Diana M. González-Gironès, Esmeralda de la Banda, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Eva M. González-Barca, Joan Gil   +12 more
doaj   +3 more sources

Concurrent hepatic cirrhosis and chronic lymphocytic leukemia: a challenging coexistence: a case report [PDF]

Journal of Medical Case Reports
Background Chronic lymphocytic leukemia, a common B-cell malignancy in the elderly, is characterized by lymphocytosis, lymphadenopathy, and cytopenia.
Fatemeh Khodadadpour Mahani, Nazanin Zeinali Nezhad, Reza Ghaderi, Elham Jafari, Mana Khazaeli, Samaneh Omidi Kermanshahaninejad, Behrang Shamsinejad   +6 more
doaj   +2 more sources

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]

, 2015
Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa, Castelli, Monica, Chiodin, Giorgia, Facco, Monica, Frezzato, Federica, Gattazzo, Cristina, Giorgi, CARLO ALBERTO, Lessi, Federica, Martini, Veronica, Piazza, Francesco, Semenzato, GIANPIETRO CARLO, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea, Zambello, Renato   +15 more
core   +11 more sources

Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia

Haematologica, 2018
Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1
Hana Plešingerová, Pavlína Janovská, Archana Mishra, Lucie Smyčková, Lucie Poppová, Antonín Libra, Karla Plevová, Petra Ovesná, Lenka Radová, Michael Doubek, Šárka Pavlová, Šárka Pospíšilová, Vítězslav Bryja   +12 more
doaj   +1 more source

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations

Haematologica, 2018
Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown.
Andreas Agathangelidis, Viktor Ljungström, Lydia Scarfò, Claudia Fazi, Maria Gounari, Tatjana Pandzic, Lesley-Ann Sutton, Kostas Stamatopoulos, Giovanni Tonon, Richard Rosenquist, Paolo Ghia   +10 more
doaj   +1 more source

SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

Haematologica, 2016
I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this disease.
Nili Dezorella, Ben-Zion Katz, Mika Shapiro, Aaron Polliack, Chava Perry, Yair Herishanu   +5 more
doaj   +1 more source

Cytoplasmic immunoglobulins in chronic lymphocytic leukemia B cells [PDF]

Blood, 1987
It is generally assumed that chronic lymphocytic leukemia of B cell origin (B-CLL) is characterized by the presence of surface membrane immunoglobulins (SmIg) and by the absence of cytoplasmic immunoglobulins (CyIg). In a variable number of cases SmIg are not detectable because of their low density on the cellular surface.
G, Pianezze, I, Gentilini, M, Casini, P, Fabris, P, Coser   +4 more
openaire   +3 more sources

Guess what: Chronic 13q14.3+/CD5‐ /CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23‐ mantle cell lymphoma in lymph nodes! [PDF]

, 2003
Cytometry B Clin Cytom. 2003 Jan;51(1):41-4. Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
BROCHADO, P., CABEDA, J.M., CANELHAS, A., DOS ANJOS TEIXEIRA, M., FONSECA, S., JUSTICA, B., LIMA, M., MOTA, A., PINTO, L., QUEIROS, M.L., SANTOS, A.H., SILVA, C.   +11 more
core   +1 more source