Results 21 to 30 of about 17,826,638 (304)

Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome

Haematologica, 2018
Low-count monoclonal B-cell lymphocytosis is defined by the presence of very low numbers of circulating clonal B cells, usually phenotypically similar to chronic lymphocytic leukemia cells, whose biological and clinical significance remains elusive ...
Ignacio Criado, Arancha Rodríguez-Caballero, M. Laura Gutiérrez, Carlos E. Pedreira, Miguel Alcoceba, Wendy Nieto, Cristina Teodosio, Paloma Bárcena, Alfonso Romero, Paulino Fernández-Navarro, Marcos González, Julia Almeida, Alberto Orfao, The Primary Health Care Group of Salamanca for the Study of MBL   +13 more
doaj   +1 more source

Involvement of memory T-cells in the pathophysiology of chronic lymphocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2014
The role of T-cells in the pathogenesis of chronic lymphocytic leukemia has recently gained much attention due to the importance of the constant interaction between neoplastic B-cells with microenvironment substratum and T-cells.
Rodolfo Patussi Correia, Flavia Amoroso Matos e Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo P. Amarante-Mendes   +5 more
doaj   +1 more source

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

Haematologica, 2012
Background The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival and proliferation. Characterization of these signals and the pathways that propagate them
Francisco de Paula Careta, Stefania Gobessi, Rodrigo Alexandre Panepucci, Engin Bojnik, Fabio Morato de Oliveira, Daniel Mazza Matos, Roberto P. Falcão, Luca Laurenti, Marco A. Zago, Dimitar G. Efremov   +9 more
doaj   +1 more source

Cytoplasmic immunoglobulins in chronic lymphocytic leukemia B cells [PDF]

Blood, 1987
It is generally assumed that chronic lymphocytic leukemia of B cell origin (B-CLL) is characterized by the presence of surface membrane immunoglobulins (SmIg) and by the absence of cytoplasmic immunoglobulins (CyIg). In a variable number of cases SmIg are not detectable because of their low density on the cellular surface.
G, Pianezze, I, Gentilini, M, Casini, P, Fabris, P, Coser   +4 more
openaire   +3 more sources

Disease-specific complications of chronic lymphocytic leukemia in binet stage a patients [PDF]

, 2012
Disease-specific Complications of Chronic Lymphocytic Leukemia in Binet Stage A Patients: Analysis of Immunodeficiency, Autoimmune Constellations and Infections in the CLL1-Protocol.
Kwag, Doo Young
core   +1 more source

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

Haematologica, 2015
While the renal complications of plasma cell dyscrasia have been well-described, most information in patients with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis is derived from case reports. This is a retrospective analysis of patients
Paolo Strati, Samih H. Nasr, Nelson Leung, Curtis A. Hanson, Kari G. Chaffee, Susan M. Schwager, Sara J. Achenbach, Timothy G. Call, Sameer A. Parikh, Wei Ding, Neil E. Kay, Tait D. Shanafelt   +11 more
doaj   +1 more source

Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases

Revista Brasileira de Hematologia e Hemoterapia, 2015
BACKGROUND: Monoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis.
Daniel Mazza Matos, Felipe Magalhães Furtado, Roberto Passetto Falcão   +2 more
doaj   +1 more source

Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders

Haematologica, 2014
Chronic antigen-stimulation has been recurrently involved in the earlier stages of monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia and other B-cell chronic lymphoproliferative disorders.
Ana Henriques, Arancha Rodríguez-Caballero, Ignacio Criado, Anton W. Langerak, Wendy G. Nieto, Quentin Lécrevisse, Marcos González, Emília Cortesão, Artur Paiva, Julia Almeida, Alberto Orfao   +10 more
doaj   +1 more source

The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia

Haematologica, 2015
Chronic lymphocytic leukemia is a malignancy of mature auto-reactive B cells. Genetic and functional studies implicate B-cell receptor signaling as a pivotal pathway in its pathogenesis.
Adrian Wiestner
doaj   +1 more source

Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients

Haematologica, 2011
Background Signaling through the B-cell receptor appears to be a major contributor to the pathogenesis of chronic lymphocytic leukemia. Toll-like receptors bridge the innate and adaptive immune responses by acting as co-stimulatory signals for B cells ...
Eleni Arvaniti, Stavroula Ntoufa, Nikos Papakonstantinou, Tasoula Touloumenidou, Nikolaos Laoutaris, Achilles Anagnostopoulos, Klea Lamnissou, Federico Caligaris-Cappio, Kostas Stamatopoulos, Paolo Ghia, Marta Muzio, Chrysoula Belessi   +11 more
doaj   +1 more source