Results 31 to 40 of about 17,826,638 (304)

Comparison of microRNA expression in high-count monoclonal B-cell lymphocytosis and Binet A chronic lymphocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia
Background Evidence suggests that monoclonal B-cell lymphocytosis precedes all chronic lymphocytic leukemia cases, although the molecular mechanisms responsible for disease progression are not understood.
Felipe Magalhães Furtado, Priscila Santos Scheucher, Bárbara Amélia Santana, Dalila Lucíola Zanette, Rodrigo do Tocantins Calado, Eduardo Magalhães Rego, Daniel Mazza Matos, Roberto Passetto Falcão   +7 more
doaj   +1 more source

Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies

Haematologica, 2013
While many prognostic markers in B-cell chronic lymphocytic leukemia provide insight into the biology of the disease, few have been demonstrated to be useful in the daily management of patients.
Alessandra Cesano, Omar Perbellini, Erik Evensen, Charles C. Chu, Federica Cioffi, Jason Ptacek, Rajendra N. Damle, Roberto Chignola, James Cordeiro, Xiao-jie Yan, Rachael E. Hawtin, Ilaria Nichele, Jodi R. Ware, Chiara Cavallini, Ornella Lovato, Roberta Zanotti, Kanti R. Rai, Nicholas Chiorazzi, Giovanni Pizzolo, Maria T. Scupoli   +19 more
doaj   +1 more source

Prognostic factors for survival in patiens with chronic lymphocytic leukemia [PDF]

, 2012
The purpose of this study is to analyse the quality of the prognostic factors to prognose the survival time and progression for patients with chronic lymphocytic leukemia (CLL) in early stage.
Wijaya, Ferry
core   +1 more source

Prognostic significance of Fc receptor-like 1 in patients with chronic lymphocytic leukemia, hairy cell leukemia, and various B-cell non-Hodgkin's lymphoma

Leukemia Research Reports, 2019
Fc receptor-like 1 (FCRL1) positively regulates B-cell responses and may involve in the pathogenesis of B-cell malignancies. This study examined the expression pattern of FCRL1 in B-cell non-Hodgkin's lymphoma patients using real-time PCR and flow ...
Zahra Yousefi, Nahid Eskandari
doaj   +1 more source

Survival mechanisms in B lymphoid malignancies and associated therapies [PDF]

, 2011
PhDThe apoptotic pathway plays critical roles in regulating lymphocyte survival throughout B cell development, maturation and differentiation. The whole process involves clonal expansion. In the normal B lymphocyte population the majority of cells and
Su, Bo
core   +4 more sources

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Haematologica, 2018
Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease.
Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne Lucas, Manuela Zucknick, Axel Benner, Andrew Clear, Sibylle Ohl, Selcen Öztürk, Thorsten Zenz, Stephan Stilgenbauer, Min Li-Weber, Peter H. Krammer, John G. Gribben, Peter Lichter, Martina Seiffert   +15 more
doaj   +1 more source

Quantitative flow cytometric evaluation of CD200, CD123, CD43 and CD52 as a tool for the differential diagnosis of mature B-cell neoplasms

Revista Brasileira de Hematologia e Hemoterapia
Background Distinction between mature B-cell neoplasms can be difficult due to overlapping of immunologic features and clinical manifestations. This study investigated whether quantifying mean fluorescence intensity of four monoclonal antibodies in a ...
Elissandra Machado Arlindo, Natália Aydos Marcondes, Flavo Beno Fernandes, Gustavo Adolpho Moreira Faulhaber   +3 more
doaj   +1 more source

The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells

Haematologica, 2013
Phosphatidylinositol-3-kinase pathway is constitutively activated in chronic lymphocytic leukemia mainly due to microenvironment signals, including stromal cell interaction and CXCR4 and B-cell receptor activation.
Laia Rosich, Ifigènia Saborit-Villarroya, Mónica López-Guerra, Sílvia Xargay-Torrent, Arnau Montraveta, Marta Aymerich, Neus Villamor, Elias Campo, Patricia Pérez-Galán, Gaël Roué, Dolors Colomer   +10 more
doaj   +1 more source

B‐Cell Chronic Lymphocytic Leukemia in a Cat

Veterinary Clinical Pathology
ABSTRACT Background An 8.8‐year‐old male neutered Persian cat was presented with a history of recent intermittent mild lethargy, hyporexia, and weight loss. Physical examination revealed pale mucous membranes, an enlarged right mandibular lymph node, and organomegaly suspected to be an enlarged
James Andre Mori, Emma Stacey, Yelda El Helou, Dorothee Bienzle   +3 more
openaire   +2 more sources

The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion

Haematologica, 2012
Background In spite of potent first-line therapies for chronic lymphocytic leukemia, treatment remains palliative and all patients frequently relapse. Treatment options for these patients are more limited.
Viola Biberacher, Thomas Decker, Madlen Oelsner, Michaela Wagner, Christian Bogner, Burkhard Schmidt, Robert J. Kreitman, Christian Peschel, Ira Pastan, Christian Meyer zum Büschenfelde, Ingo Ringshausen   +10 more
doaj   +1 more source