Results 11 to 20 of about 1,722,968 (253)

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]

, 2012
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
McCaig, Alison M., Alison M McCaig, Alison M. Mccaig, Cosimo Emilio, Alison M. Michie, Leach Michael T., Alison M Michie, Emilio Cosimo, Michael T. Leach, McCaig Alison M., Michael T Leach, Michie, Alison M., Michie Alison M., Cosimo, Emilio, Leach, Michael T.   +14 more
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Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment [PDF]

, 2004
Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal
Hallek, M., Emmerich, B., Bergmann, M.
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Expression patterns of CD180 in the lymph nodes of patients with chronic lymphocytic leukaemia [PDF]

, 2021
There is strong evidence implicating microenvironmental sensors, including toll-like receptors (TLRs), in the pathobiology of chronic lymphocytic leukaemia (CLL).1, 2 We have previously demonstrated that the orphan TLR CD180 is heterogeneously expressed ...
Sayed, U, Lydyard, P, Edwards, K., John G. Gribben, Nino Porakishvili, Sergey Krysov, Nathwani, A, Porakishvili, N, Zaitseva, K, Amit Nathwani, Volpi, E., Peter Lydyard, Edwards, K, Sayed, U., Uzma Sayed, Gribben, JG, Porakishvili, N., Krysov, S., Krysov, S, Kurtis Edwards, Zaitseva, K., Volpi, EV, Lydyard, P.M., Nathwani, D.A., Kristina Zaitseva, Emanuela V. Volpi, Gribben, J., Lydyard, P., Volpi, V.E.   +28 more
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In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia [PDF]

, 2010
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world, and continues to have very low cure rates. The bulk of the tumour cells are non-cycling peripheral cells that accumulate from a minority of dividing cells within ...
Hayden, Rachel Elizabeth
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Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 [PDF]

, 2013
The authors acknowledge TENOVUS Tayside for funding the studyTenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-
Coates, Philip J., Groves, M.J., Prescott, A.R., Nicolaou, A., Murray, Karen, Ganley, Ian G.; id_orcid, Lain, S., Tauro, S., Haydock, S., Appleyard, V., Ganley, I.G., James, John, Nicolaou, Anna; id_orcid, Cunningham, Joan, Cunningham, J., Tauro, Sudhir, Murray, K., Prescott, Alan R., Drbal, Abed Alnaser A.A., Coates, P.J., James, J., MacCallum, S., Lain, Sonia, Drbal, A.A., MacCallum, Stephanie F., Drbal, Abed A., Haydock, Sally, Westwood, N.J., Prescott, Alan R.; id_orcid, Ganley, Ian G., Groves, Michael J., Nicolaou, Anna, Westwood, Nicholas J., Appleyard, Virginia, Prescott, AR, Murray, K, Nicolaou, A, Haydock, S, Drbal, AA, Cunningham, J, Appleyard, V, James, J, MacCallum, SF, Groves, MJ   +43 more
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Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

Nature Communications, 2022
Proteomics can be used to refine cancer classification. Here, the authors characterise chronic lymphocytic leukaemia patients by proteogenomics, and identified a subtype of patients with poor prognosis associated with aberrant B cell receptor signalling.
Sophie A. Herbst, Mattias Vesterlund, Alexander J. Helmboldt, Rozbeh Jafari, Ioannis Siavelis, Matthias Stahl, Eva C. Schitter, Nora Liebers, Berit J. Brinkmann, Felix Czernilofsky, Tobias Roider, Peter-Martin Bruch, Murat Iskar, Adam Kittai, Ying Huang, Junyan Lu, Sarah Richter, Georgios Mermelekas, Husen Muhammad Umer, Mareike Knoll, Carolin Kolb, Angela Lenze, Xiaofang Cao, Cecilia Österholm, Linus Wahnschaffe, Carmen Herling, Sebastian Scheinost, Matthias Ganzinger, Larry Mansouri, Katharina Kriegsmann, Mark Kriegsmann, Simon Anders, Marc Zapatka, Giovanni Del Poeta, Antonella Zucchetto, Riccardo Bomben, Valter Gattei, Peter Dreger, Jennifer Woyach, Marco Herling, Carsten Müller-Tidow, Richard Rosenquist, Stephan Stilgenbauer, Thorsten Zenz, Wolfgang Huber, Eugen Tausch, Janne Lehtiö, Sascha Dietrich   +47 more
doaj   +1 more source

Stomach Cancer in a Patient with Chronic Lymphocytic Leukaemia

Креативная хирургия и онкология, 2019
Introduction. Chronic lymphocytic leukaemia (CLL) is a malignant clonal lymphoproliferative disorder characterised by the accumulation of atypical mature CD5/CD19/CD23-positive B lymphocytes, predominantly in blood, bone marrow, lymph glands, liver and ...
R. A. Maier, B. A. Bakirov, M. V. Timerbulatov   +2 more
doaj   +1 more source

FT-infrared spectroscopic studies of lymphoma, lymphoid and myeloid leukaemia cell lines [PDF]

, 2007
This paper presents a novel method to characterise spectral differences that distinguish leukaemia and lymphoma cell lines. This is based on objective spectral measurements of major cellular biochemical constituents and multivariate spectral ...
Babrah, Jaspreet, McCarthy, Keith P., Lush, Richard, Bessant, Conrad M., Rye, Adam D., Stone, Nicholas, Jaspreet Babrah, Adam D. Rye, Nicholas Stone, Keith P. McCarthy, Richard Lush, Conrad Bessant   +11 more
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Chronic lymphocytic leukaemia: An immunobiology approach [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2008
B cell chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia that follows an extremely variable clinical course. Several important prognostic parameters defining pathogenic and clinical subgroups of CLL have been identified and validated
Kostareli Efterpi, Smilevska Tatjana, Stamatopoulos Kostas, Kouvatsi Anastasia, Anagnostopoulos Achilles   +4 more
doaj   +1 more source

EZN-2208 treatment suppresses chronic lymphocytic leukaemia by interfering with environmental protection and increases response to fludarabine [PDF]

Open Biology, 2020
The transcription factor HIF-1α is overexpressed in chronic lymphocytic leukaemia (CLL), where it promotes leukaemia progression by favouring the interaction of leukaemic cells with protective tissue microenvironments. Here, we tested the hypothesis that
Roberta Valsecchi, Nadia Coltella, Daniela Magliulo, Lucia Bongiovanni, Lydia Scarfò, Paolo Ghia, Maurilio Ponzoni, Rosa Bernardi   +7 more
doaj   +1 more source