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Resistance to Bruton Tyrosine Kinase Inhibitors
Hematology/Oncology Clinics of North AmericaTargeting Bruton tyrosine kinase (BTK) has revolutionized the therapy for chronic lymphocytic leukemia. As patients remain on therapy, however, resistance develops progressively over time. The most common mechanism of resistance to covalent BTK inhibitors is mutation of the C481 target residue to serine, abrogating covalent binding.
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Pharmacovigilance analysis of cardiac risks associated with Bruton tyrosine kinase inhibitors
Expert Opinion on Drug Safety, 2023Yang Cao, Xiaofei Ye
exaly
Emerging small-molecule inhibitors of the Bruton’s tyrosine kinase (BTK): Current development
European Journal of Medicinal Chemistry, 2021Tian-tai Zhang, Dongmei Wang
exaly

