Results 101 to 110 of about 14,500 (123)

Abstract 2970: Overcoming mechanisms of escape from treatments for multiple myeloma with ISB 2001, a potential first-in-class trispecific BCMA and CD38 targeted T cell engager

Cancer Research, 2023
Immune therapies targeting a single tumor associated antigen (TAA) have demonstrated their efficacy against multiple myeloma (MM) in recent years. However, durable responses are still limited, which may be due to downregulation of the targeted TAA or ...
M. Pihlgren, Laura Carretero, Jérémy Berret, Olivia Hall, C. Estoppey, A. Drake, Daniela Pais, J. Macoin, M. Chimen, Perrine Suere, Emily Nallet, Blandine Pouleau, E. Stainnack, J. Loyau, T. Monney, Aurore Delachat, C. Dreyfus, S. Blein, Z. Kaya, T. Matthes, Rebecca Croasdale-wood, James Edwards, C. Edwards, L. Mbow, M. Dyson, C. Konto, Ankit Srivastava, Eugene Zhukovshy, M. Perro   +28 more
semanticscholar   +1 more source

Abstract BS1-1: PR

Cancer Research, 2022
Much debate exists surrounding how progesterone receptor (PR) expression and activation by native progesterone affects hormone receptor (HR)-positive breast cancer cells.
C. Hagan
semanticscholar   +1 more source

Acceptor Subsite Mutants of Limosilactobacillus fermentum NCC 2970 GtfB 4,3-α-Glucanotransferase Regulate the Ratio of (α1 → 3)/(α1 → 6) Linkages in Biosynthesized α-Glucans.

Journal of Agricultural and Food Chemistry
Limosilactobacillus fermentum NCC 2970 GtfB (Lf2970 GtfB) is the only characterized 4,3-α-glucanotransferase (4,3-α-GTase) in the glycoside hydrolase (GH) 70 family belonging to the GtfB subfamily.
Ying Chen, Jing Dong, Xiaoxiao Li, Zhengyu Jin, Birte Svensson, Yuxiang Bai   +5 more
semanticscholar   +1 more source

Abstract BS1-2: Myeloid-derived suppressor cells: many facets of regulation of tumor progression

, 2018
Tumor associated macrophages (TAM), myeloid derived suppressor cells (MDSC), represented by PMN-MDSC and M-MDSC, and dendritic cells (DC) are major components of tumor microenvironment playing critical role in tumor progression.
D. Gabrilovich
semanticscholar   +1 more source

Abstract BS1-2: Neutrophil extracellular traps promote breast cancer metastasis

Invited Speaker Abstracts, 2019
Cancer cells from a primary tumor can disseminate to other tissues, but remain dormant and clinically undetectable for many years. Little is known about the cues that cause these dormant cells to “awaken”, resume proliferation, and develop into ...
M. Egeblad
semanticscholar   +1 more source

Abstract 2970: MEDI4276, a HER2-targeting antibody tubulysin conjugate, displays potent invitroandin vivoactivity in preclinical studies

, 2016
Antibody drug conjugates (ADCs) combine the specificity of antibodies with the potent cytotoxicity of small molecule drugs and have shown to provide therapeutic options for various cancers.
John Y Li, D. Toader, Samuel R. Perry, Vanessa M. Muniz-Medina, Leslie K Wetzel, M. Rebelatto, M. Hinrichs, R. Fleming, Binyam Z Bezabeh, P. Thompson, N. Dimasi, B. Lam, Xiang-Qing Yu, Changshou Gao, R. Dixit, S. Coats, J. Osbourn, Herren Wu   +17 more
semanticscholar   +1 more source

Strong decays of the bottom mesons B1(5721), B2(5747), Bs1(5830), Bs2(5840) and B(5970)

, 2014
.In this article, we study the two-body strong decays of the bottom mesons with the heavy meson effective theory in the leading-order approximation and obtain all the analytical expressions of the decay widths of the light pseudoscalar meson transitions ...
Zhi-Gang wang
semanticscholar   +1 more source

Abstract 2970: Whole genome sequencing analysis of multiple liver cancer nodules for determination of causal events for multi-occurrence

, 2015
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide.
Mayuko Furuta, Akihiro Fujimoto, M. Ueno, S. Hayami, Y. Kawakami, K. Gotoh, T. Tsunoda, S. Miyano, H. Ohdan, K. Chayama, H. Yamaue, H. Nakagawa   +11 more
semanticscholar   +1 more source

Biological potential of Pseudomonas sp. BS1 in the control of Phytophthora root rot of soybean

, 2012
In this study, the biological potential of Pseudomonas sp. BS1 in the control of Phytophthora root rot of soybean was investigated. Fermentation filtrates of Pseudomonas sp.
J. Hou, Sining Bi, Lei Yan, Y. Zuo, Yan-jie Wang, Tong Liu, Jiewei Zhu   +6 more
semanticscholar   +1 more source

Abstract BS1-1: Essential Role for Wnt Signaling in Metastatic Colonization

, 2012
Metastatic growth in distant organs is the major cause of cancer mortality. Formation of metastasis is a multi-step process with several rate-limiting steps: while dissemination of tumour cells appears to be an early and frequent event, successful ...
J. Huelsken
semanticscholar   +1 more source