Results 301 to 310 of about 80,266 (330)
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On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors
Cancer Discovery, 2022Abstract Resistance to noncovalent BTK inhibitors is mediated by non-C481 BTK and PLCγ2 mutations.
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Cardiotoxicity of BTK inhibitors: ibrutinib and beyond
Expert Review of Hematology, 2022Introduction The development of Brutons Tyrosine Kinase (BTK) inhibitors has transformed the treatment of B-cell malignancies and other non-malignant conditions. Management of the unique cardiotoxic profile of these agents requires prompt recognition and
Bradley W Christensen +2 more
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Current Topics in Medicinal Chemistry, 2022
Bruton's tyrosine kinase (BTK) plays a vital role in B-cell antigen receptor (BCR) signalling transduction pathway. Controlling BCR signalling by BTK inhibitors is a promising therapeutic approach for the treatment of inflammatory and autoimmune diseases.
Debasis Das +2 more
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Bruton's tyrosine kinase (BTK) plays a vital role in B-cell antigen receptor (BCR) signalling transduction pathway. Controlling BCR signalling by BTK inhibitors is a promising therapeutic approach for the treatment of inflammatory and autoimmune diseases.
Debasis Das +2 more
semanticscholar +1 more source
Development of btk Transgenic Mice
1995B cell development is characterized by the orderly expression of cell surface markers and responses to specific activation signals [1]. Tyrosine kinases are involved in signalling pathways that regulate these events [2]. Bruton’s tyrosine kinase (Btk) is a tyrosine kinase expressed in B and myeloid cells [3,4].
E A, Faust +3 more
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BTK-Hemmung plus Chemotherapie
Info Onkologie, 2015In der Phase-III-Studie HELIOS wurde untersucht, ob die Kombination von Ibrutinib mit einer Chemotherapie einen zusatzlichen Vorteil fur Patienten mit rezidivierter/refraktarer CLL bietet.
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Science Signaling, 2001
The members of the Tec family of tyrosine kinases contain Src homology 2 (SH2), SH3, and pleckstrin homology (PH) domains, in addition to their kinase domains. Unlike the Src family of tyrosine kinases, which have a negative regulatory tyrosine located at their COOH-termini, members of the Tec family do not have an obvious negative ...
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The members of the Tec family of tyrosine kinases contain Src homology 2 (SH2), SH3, and pleckstrin homology (PH) domains, in addition to their kinase domains. Unlike the Src family of tyrosine kinases, which have a negative regulatory tyrosine located at their COOH-termini, members of the Tec family do not have an obvious negative ...
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BTK inhibitors and next-generation BTK-targeted therapeutics for B-cell malignancies
Archives of Pharmacal ResearchBruton's tyrosine kinase (BTK) is a therapeutically validated drug target. Small-molecule inhibitors of BTK have changed the treatment paradigms of multiple B-cell malignancies and evolved over three generations to overcome clinical challenges. Four drugs are now approved by the FDA, including the first-in-class drug ibrutinib and successively approved
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Bruton's Tyrosine Kinase (Btk)
2012Bruton's tyrosine kinase (Btk) is a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B-cell development, differentiation and signalling through the B-cell antigen receptor (BCR) as is evident by its genetic association to a human primary immunodeficiency disease known as X-linked Agammaglobulinemia (XLA).
MARK E. SCHNUTE +2 more
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