Results 91 to 100 of about 655,557 (182)

Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma

Journal of Hematology & Oncology, 2017
Background Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms.
P. Balsas, A. Esteve-Arenys, J. Roldán, L. Jiménez, V. Rodríguez, J. G. Valero, A. Chamorro-Jorganes, R. Puig de la Bellacasa, J. Teixidó, A. Matas-Céspedes, A. Moros, A. Martínez, E. Campo, A. Sáez-Borderías, J. I. Borrell, P. Pérez-Galán, D. Colomer, G. Roué   +17 more
doaj   +1 more source

Challenging Host Specificity: Malacosporean Parasite Dynamics—Tetracapsuloides bryosalmonae Beyond Salmonids—An Infection Experiment

Journal of Fish Diseases, EarlyView.
ABSTRACT Proliferative Kidney Disease (PKD) is a severe parasitic disease of salmonids caused by the malacosporean endoparasite Tetracapsuloides bryosalmonae. In the fish intermediate host, the parasite is disseminated via the circulatory system and ultimately reaches the kidney, where it matures before releasing infective spores into the environment ...
Céline Möckli, Nicolas Diserens, Gary Delalay, Gastón Moré, Heike Schmidt‐Posthaus   +4 more
wiley   +1 more source

Discovery of a Potent, Covalent BTK Inhibitor for B‑Cell Lymphoma

, 2015
BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling and cellular assays to ...
Constantine S. Mitsiades (348466), Nathanael S. Gray (150685), Tian, Bei, Jing Liu (38537), Feiyang Liu (381060), Jennifer R. Brown (1319274), Binhua Li (1319268), Wang, Aoli, Guang Yang (154978), Liu, Jing, Mitsiades, Constantine, Sara J. Buhrlage (1319271), Chen Hu (317374), James D. Griffin (203544), Wu, Hong, Wenchao Wang (242659), Li, Hong, Qingsong Liu (381059), Buhrlage, Sara J., Yang, Guang, Wang, Wenchao, Douglas W. McMillin (348456), Yanke Liang (1319277), Bei Tian (1319283), Chen, Yongfei, Gray, Nathanael, Hu, Chen, Li, Binhua, Liu, Qingsong, Weisberg, Ellen, Hong Wu (105254), Beilei Wang (298371), Liang, Yanke, Brown, Jennifer R., Steven P. Treon (1319286), Yongfei Chen (1319262), Ellen L. Weisberg (1301688), Wang, Jinhua, Hong Li (20183), McMillin, Douglas W., Junting Liang (1319280), Liu, Feiyang, Treon, Steven, Griffin, James, Liang, Junting, Jinhua Wang (1506), Wang, Beilei, Aoli Wang (1319265), Zheng Zhao (182853), Zhao, Zheng   +49 more
core   +1 more source

Reactogenicity and Immunogenicity of RSV Vaccines in Immunocompromised Individuals With Hematological Malignancies

Transplant Infectious Disease, EarlyView.
In adults with hematologic malignancies, RSV vaccination was safe and induced antibody and T‐cell responses. However, antibody levels were lower and declined more rapidly than in healthy controls. While early immune responses were evident, reduced magnitude and durability of protection suggest the need for optimized vaccination strategies in this high ...
Alisse Hannaford, Zoe Swank, Simon D. van Haren, Natalie Izaguirre, Caitlin Syphurs, Zhou Lan, Bridget Yates, Urwah Kanwal, Grace Valentine, Ella Woehl, David Regan, Hannah Levine, Alexandra Tong, Maria Shehata, Fathia Oladipupo, Colleen Sedney, Kevin Ryff, Sanya Thomas, Joann Diray‐Arce, Xiaofang Li, Kimberly A. Dufresne, Lindsey A. Parisi, Aidan Eustace, Louise Hansen, David R. Walt, Ofer Levy, Amar Kelkar, Robert J. Soiffer, Vincent T. Ho, Lindsey R. Baden, Nicolas C. Issa, Ann E. Woolley, Amy C. Sherman   +32 more
wiley   +1 more source

Visible‐Light‐Initiated, Nickel‐Catalyzed Aminocarbonylation of Alkynyl Iodides to 2‐Ynamides

Advanced Synthesis &Catalysis, Volume 368, Issue 19, 1 October 2026.
Visible light initiates a nickel‐catalyzed aminocarbonylation of alkynyl iodides, enabling the synthesis of 2‐ynamides under low carbon monoxide pressure. The method operates under mild conditions, tolerates a broad substrate scope, and proceeds through a light‐triggered nickel(I)/nickel(III) carbonylative pathway.
Michael Weiser, Alexander Frischauf, Berthold Stöger, Ertan Turhan, Dennis Kurzbach, Katharina Bica‐Schröder   +5 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Cardiovascular Toxicity Associated With Bispecific Antibodies in Hematological Malignancies: A Comprehensive Pharmacovigilance Analysis

American Journal of Hematology, Volume 101, Issue 10, Page 2546-2556, October 2026.
ABSTRACT Cardiovascular adverse events (CVAEs) associated with bispecific T‐cell engaging antibodies (BsAbs) have not been systematically investigated across approved agents. In this disproportionality analysis of FAERS (December 2014–September 2025), reports listing BsAbs as the primary suspected drug (n = 7647) were compared with all other drugs in ...
Malak Munir, Ahmed Sayed, Dae Hyun Lee, Sanam Ghazi, Mustafa M. Houmsse, Saad Badat, Abdul Moeed, Avirup Guha, Daniel Addison, Narendranath Epperla   +9 more
wiley   +1 more source

Extranodal Organ Involvement in Chronic Lymphocytic Leukemia: Clinical Features and Outcomes With Bruton Tyrosine Kinase and BCL‐2 Inhibitors

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Although chronic lymphocytic leukemia (CLL) typically follows an indolent course involving blood, lymph nodes, and bone marrow, extranodal organ involvement is rare and poorly characterized. Methods We retrospectively analyzed 19 patients with histologically confirmed extranodal CLL or small lymphocytic lymphoma (SLL), assessing ...
Finn J. Schulze, Evgenii Shumilov, Akhil Behringer, Andrea Kerkhoff, Matthias Eckhardt, Simone Bätker, Markus Maulhardt, Georg Lenz, Alexander Pohlmann   +8 more
wiley   +1 more source

Cardiovascular Toxicity of BTKi in Chronic B-Cell Malignancies

Reviews in Cardiovascular Medicine
Bruton's tyrosine kinase (BTK) inhibitors are important targeted drugs for treating chronic B-cell malignancies, and have played a key role in improving patient prognosis and treatment efficacy.
Haojian Gan, Junling Lin, Qiyin Sun, Jiayi Xu, Qingjian He, Shuo Chen, Yu Feng, Bicheng Hu, Wenjuan Wang   +8 more
doaj   +1 more source

The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View

Journal of Experimental Pharmacology, 2021
Francesco Paolo Tambaro,1 Danilo De Novellis,1,2 William G Wierda3 1Unità Operativa di Trapianto di Midollo Osseo e Servizio Trasfusionale, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italy; 2Department of Precision Medicine ...
Tambaro FP, De Novellis D, Wierda WG
doaj