Results 91 to 100 of about 636,170 (221)

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

, 2016
The Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib has shown impressive clinical efficacy in a range of B-cell malignancies. However, acquired resistance has emerged, and second generation therapies are now being sought.
Luciana Burton (3105537), Pawan Bir Kohli (1947676), Christine Tam (1346388), Jiansheng Wu (193208), Krista Bowman (1443880), Adam R. Johnson (1638925), Hong Li (20183), Arna Katewa (2399662), Regina Choy (3105528), Emily Gogol (3105525), Elicia Penuel (357323), Alberto Estevez (3105534), Philippe Bergeron (1443877), Lisa D. Belmont (640344), Yvonne Franke (16490), Kyle Mortara (1475083), Daniel F. Ortwine (1600621), Charles Eigenbrot (1346406), James J. Crawford (1586260), Christine Yu (1346364), May Lin (3105531), Wendy B. Young (2201095)   +21 more
core   +1 more source

Bruton’s Tyrosine Kinase: A Double-Edged Sword in Cancer and Aging

Kinases and Phosphatases
Bruton’s tyrosine kinase (BTK) is a key signaling molecule involved in both hematological malignancies and solid tumors. In B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), BTK mediates B-cell receptor ...
Zahraa Qusairy, Miran Rada
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Pirtobrutinib in Richter syndrome: Outcomes from the named patient programme in Italy

British Journal of Haematology, EarlyView.
Isacco Ferrarini, Daniela Estefania Banegas, Andrea Bernardelli, Alessia Moioli, Francesca Maria Quaglia, Ester Lovato, Anna Maria Frustaci, Massimiliano Postorino, Davide Facchinelli, Monica Tani, Francesca Cibien, Chandrakala Toldo, Elisa Lucchini, Roberto Marasca, Marzia Varettoni, Chiara Rusconi, Lucia Farina, Andrea Visentin, Riccardo Moia, Carlo Visco   +19 more
wiley   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance

, 2023
Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance.
Kahn Rhrissorrakrai, Zain, Rula,, Gad Getz, Davids, Matthew S.,, Wang, Qing,, Leshchiner, Ignaty,, Smith, C. I.Edvard, Zhou, Yinglu, Wang, Qing, Svitlana Tyekucheva, Parida, Laxmi,, Slowik, Kara, Levovitz, Chaya,, Aishath Naeem, Parida, Laxmi, Naeem, Aishath,, Stephen Martindale, James A. Lederer, Jacobs, Raquel A.,, Getz, Gad,, Cha, Justin, Saksena, Gordon, Kim, Annette S.,, Mauno Vihinen, Brown, Jennifer R.,, Fernandes, Stacey M., Leshchiner, Ignaty, Yinglu Zhou, Slowik, Kara,, Ren, Yue, Lund University., Zain, Rula, Laxmi Parida, Jennifer R. Brown, Utro, Filippo, Danysh, Brian P., Danysh, Brian P.,, Martindale, Stephen, Zhou, Yinglu,, Rhrissorrakrai, Kahn,, Justin Cha, Rhrissorrakrai, Kahn, Chaya Levovitz, Cha, Justin,, Brian P. Danysh, Raquel A. Jacobs, Jacobs, Raquel A., Utro, Filippo,, Tyekucheva, Svitlana, Yue Ren, Naeem, Aishath, Gordon Saksena, C. I. Edvard Smith, Davids, Matthew S., Levovitz, Chaya, Rula Zain, Martindale, Stephen,, Ren, Yue,, Lederer, James A.,, Annette S. Kim, Filippo Utro, Qing Wang, Brown, Jennifer R., Kara Slowik, Matthew S. Davids, Kim, Annette S., Smith, C. I.Edvard,, Saksena, Gordon,, Vihinen, Mauno, Fernandes, Stacey M.,, Stacey M. Fernandes, Vihinen, Mauno,, Ignaty Leshchiner, Getz, Gad, Tyekucheva, Svitlana,, Lederer, James A.   +75 more
core   +1 more source

Challenging Host Specificity: Malacosporean Parasite Dynamics—Tetracapsuloides bryosalmonae Beyond Salmonids—An Infection Experiment

Journal of Fish Diseases, EarlyView.
ABSTRACT Proliferative Kidney Disease (PKD) is a severe parasitic disease of salmonids caused by the malacosporean endoparasite Tetracapsuloides bryosalmonae. In the fish intermediate host, the parasite is disseminated via the circulatory system and ultimately reaches the kidney, where it matures before releasing infective spores into the environment ...
Céline Möckli, Nicolas Diserens, Gary Delalay, Gastón Moré, Heike Schmidt‐Posthaus   +4 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Reactogenicity and Immunogenicity of RSV Vaccines in Immunocompromised Individuals With Hematological Malignancies

Transplant Infectious Disease, EarlyView.
In adults with hematologic malignancies, RSV vaccination was safe and induced antibody and T‐cell responses. However, antibody levels were lower and declined more rapidly than in healthy controls. While early immune responses were evident, reduced magnitude and durability of protection suggest the need for optimized vaccination strategies in this high ...
Alisse Hannaford, Zoe Swank, Simon D. van Haren, Natalie Izaguirre, Caitlin Syphurs, Zhou Lan, Bridget Yates, Urwah Kanwal, Grace Valentine, Ella Woehl, David Regan, Hannah Levine, Alexandra Tong, Maria Shehata, Fathia Oladipupo, Colleen Sedney, Kevin Ryff, Sanya Thomas, Joann Diray‐Arce, Xiaofang Li, Kimberly A. Dufresne, Lindsey A. Parisi, Aidan Eustace, Louise Hansen, David R. Walt, Ofer Levy, Amar Kelkar, Robert J. Soiffer, Vincent T. Ho, Lindsey R. Baden, Nicolas C. Issa, Ann E. Woolley, Amy C. Sherman   +32 more
wiley   +1 more source