Results 1 to 10 of about 4,101 (234)

Resistance Mutations to BTK Inhibitors Originate From the NF-κB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway

Frontiers in Immunology, 2021
Since the first clinical report in 2013, inhibitors of the intracellular kinase BTK (BTKi) have profoundly altered the treatment paradigm of B cell malignancies, replacing chemotherapy with targeted agents in patients with chronic lymphocytic leukemia ...
C. I. Edvard Smith, Jan A. Burger
doaj   +1 more source

Distinct BTK inhibitors differentially induce apoptosis but similarly suppress chemotaxis and lipid accumulation in mantle cell lymphoma

BMC Cancer, 2021
Background The more selective second-generation BTK inhibitors (BTKi) Acalabrutinib and Zanubrutinib and the first-generation BTKi Ibrutinib are highlighted by their clinical effectiveness in mantle cell lymphoma (MCL), however, similarities and ...
Zhuojun Liu, Jia Liu, Tianming Zhang, Lin Li, Shuo Zhang, Hao Jia, Yuanshi Xia, Mingxia Shi, Jing Zhang, Shuhua Yue, Xiaofang Chen, Jian Yu   +11 more
doaj   +1 more source

Effects of the Btk-Inhibitors Remibrutinib (LOU064) and Rilzabrutinib (PRN1008) With Varying Btk Selectivity Over Tec on Platelet Aggregation and in vitro Bleeding Time

Frontiers in Cardiovascular Medicine, 2021
Background: Bruton tyrosine kinase inhibitors (BTKi) are used in B-cell malignancies and in development against various autoimmune diseases. Since Btk is also involved in specific pathways of platelet activation, BTKi might be considered to target ...
Rundan Duan, Luise Goldmann, Richard Brandl, Michael Spannagl, Christian Weber, Christian Weber, Christian Weber, Wolfgang Siess, Wolfgang Siess, Philipp von Hundelshausen, Philipp von Hundelshausen   +10 more
doaj   +1 more source

Unresolved questions in selection of therapies for treatment-naïve chronic lymphocytic leukemia

Journal of Hematology & Oncology, 2023
Background The treatment landscape for chronic lymphocytic leukemia (CLL) continues to undergo considerable evolution. Optimal selection of initial therapy from multiple effective options provides a major challenge for clinicians, who need to consider ...
Rory Bennett, Mary Ann Anderson, John F. Seymour   +2 more
doaj   +1 more source

P079 | Assessment by high resolution ultrasound sonography of patients with chronic lymphocytic leukemia treated with btk inhibitors (btki). clinical and pharmacoeconomic impact

Haematologica
Introduction. IWCC and ESMO guidelines suggest abdominal ultrasound (US) and superficial lymphonodes (SLN) palpation to assess CLL patients in general practice(GP).
Maria Costanza Caparello
doaj   +1 more source

Mathematical existence results for the Doi-Edwards polymer model [PDF]

, 2015
In this paper, we present some mathematical results on the Doi-Edwards model describing the dynamics of flexible polymers in melts and concentrated solutions.
Chupin, Laurent
core   +3 more sources

Arrhythmogenic Cardiotoxicity Associated With Contemporary Treatments of Lymphoproliferative Disorders

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background There are limited data on risk of arrhythmias among patients with lymphoproliferative disorders. We designed this study to determine the risk of atrial and ventricular arrhythmia during treatment of lymphoma in a real‐world setting.
Saadia Sherazi, Susan Schleede, Scott McNitt, Carla Casulo, Jeremiah E. Moore, Eugene Storozynsky, Arpan Patel, Neelima Vidula, Mehmet K. Aktas, Clive S. Zent, Ilan Goldenberg   +10 more
doaj   +1 more source

Controllability Metrics, Limitations and Algorithms for Complex Networks [PDF]

, 2014
This paper studies the problem of controlling complex networks, that is, the joint problem of selecting a set of control nodes and of designing a control input to steer a network to a target state. For this problem (i) we propose a metric to quantify the
Bullo, Francesco, Pasqualetti, Fabio, Zampieri, Sandro   +2 more
core   +3 more sources

Structure of seeds in generalized cluster algebras [PDF]

, 2015
We study generalized cluster algebras introduced by Chekhov and Shapiro. When the coefficients satisfy the normalization and quasi-reciprocity conditions, one can naturally extend the structure theory of seeds in the ordinary cluster algebras by Fomin ...
Nakanishi, Tomoki
core   +1 more source

TP53-Altered Chronic Lymphocytic Leukemia Treated With Firstline Bruton’s Tyrosine Kinase Inhibitor-Based Therapy: A Retrospective Analysis [PDF]

, 2022
Long-term follow up of prospective studies has shown that continuous Bruton\u27s tyrosine kinase inhibitor (BTKi) therapy leads to durable remissions in previously untreated patients with TP53-altered chronic lymphocytic leukemia (CLL); however, it is ...
Burger, Jan, Cherng, Hua-Jay J, Estrov, Zeev, Ferrajoli, Alessandra, Jain, Nitin, Kanagal-Shamanna, Rashmi, Kantarjian, Hagop, Keating, Michael, Khwaja, Raamis, Sampath, Deepa, Sasaki, Koji, Tang, Guilin, Thompson, Philip, Wang, Xuemei, Wierda, William G   +14 more
core   +2 more sources