Adverse Effects of Low Serum HDL-C Levels on Prognosis and Tumor Immune Microenvironment in Patients With Newly Diagnosed Chronic Lymphocytic Leukemia. [PDF]
Cancer MedABSTRACT Disorders of lipid metabolism contribute to the occurrence and progression of hematological malignancies, including chronic lymp hocytic leukemia (CLL). The objective of this study was to investigate the association between serum lipid levels and prognosis in patients with CLL.
Lv W +9 more
europepmc +2 more sources
New pieces in the BTKi resistance puzzle [PDF]
Blood, 2018 In this issue of Blood, Chen et al1 report about novel mechanisms of ibrutinib resistance related to BTK Cys481 point mutations in Waldenstrom macroglobulinemia (WM). They transfected WM and diffuse large B-cell lymphoma (DLBCL) cells with vectors containing wild-type (BTKWT) or Cys481Ser mutated (BTKCys481Ser) BTK, and examined effects of the ...
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Should Patients with Waldenström Macroglobulinemia Receive a BTK Inhibitor as Frontline Therapy?
Hemato, 2022 Waldenström Macroglobulinemia (WM) is a rare indolent lymphoma with heterogeneous clinical presentation. As there are no randomised trials suggesting the best treatment option in treatment-naive patients, guidelines suggest either rituximab-combining ...
Marina Deodato +5 more
doaj +1 more source
Real-world experience among patients with relapsed/refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure in Europe: The SCHOLAR-2 retrospective chart review study [PDF]
, 2023 Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy.
Chen J. M. H. +24 more
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A herding perspective on global games and multiplicity [PDF]
, 2003 Recently, it has been claimed that full-information multiple equilibria in games with strategic complementarities are not robust, because generalizing to allow slightly heterogeneous information implies uniqueness.
Costain, James S.
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Identification of six hub genes in mantle cell lymphoma patients with BTKi resistance
Annals of Translational Medicine, 2022 Bruton tyrosine kinase inhibitor (BTKi) resistance is an unsolved problem in the treatment of relapse/recurrence (R/R) mantle cell lymphoma (MCL). Although salvage therapy following ibrutinib resistance has been attempted in recent years, the survival of resistant patients was significantly reduced.
Liu, Shuozi +6 more
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Cell Death and Disease, 2021 Aberrant microRNA (miR) expression plays an important role in pathogenesis of different types of cancers, including B-cell lymphoid malignancies and in the development of chemo-sensitivity or -resistance in chronic lymphocytic leukemia (CLL) as well as ...
Isha Kapoor +3 more
doaj +1 more source
Blood Cancer Journal, 2022 Constitutively activated B cell receptor (BCR) signaling is a primary biological feature of chronic lymphocytic leukemia (CLL). The biological events controlled by BCR signaling in CLL are not fully understood and need investigation. Here, by analysis of
Zhiquan Wang +15 more
doaj +1 more source
Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti-spike neutralizing IgG to SARS-CoV-2 variants, but preserved antigen-specific T cell responses [PDF]
, 2023 Patients with indolent lymphoma undertaking recurrent or continuous B cell suppression are at risk of severe COVID-19. Patients and healthy controls (HC; N = 13) received two doses of BNT162b2: follicular lymphoma (FL; N = 35) who were treatment naïve ...
Aggarwal, A +21 more
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