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Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher+6 more
wiley +1 more source
From Subprime and Eurozone Crisis with Full Speed into the Next Financial Crisis
This paper offers an analysis of the road from subprime and eurozone crisis to the elements of a new systemic crisis. Our aim is to research common issues that accompany each of these crises and to explore elements that hint that the financial systems ...
Strašek Sebastjan
doaj +1 more source
Bubble nucleation around heterogeneities in $φ^4$-field theories [PDF]
Localised heterogeneities have been recently discovered to act as bubble-nucleation sites in nonlinear field theories. Vacuum decay seeded by black holes is one of the most remarkable applications. This article proposes a simple and exactly solvable $\phi^4$ model exhibiting bubble nucleation around localised heterogeneities.
arxiv +1 more source
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Decarburization and Inclusion Removal Process in Single Snorkel Vacuum Degasser
In the current work, the coupled mathematical models for decarburization, fluid flow model and inclusion collision-aggregation model were solved to investigate the spatial distribution of carbon, inclusion’s collision-aggregation and removal in a single ...
Dian-Qiao Geng, Lei Hong, He Ji-Cheng
doaj +1 more source
Bubbles Tomorrow and Bubbles Yesterday, but Never Bubbles Today? [PDF]
Considering their importance and the amount of effort that has gone into understanding them, asset price bubbles continue to perplex. The evidence of these bubbles seldom squares with what would be expected from standard asset price theory. Unlike the suggestions from theory, expectations of prices of both stocks and houses tend to be procyclical—price
openaire +4 more sources
Bubble, bubble, toil and trouble? [PDF]
From the Division of Cardiothoracic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, Tex. Disclosures: Authors have nothing to disclose with regard to commercial support. Received for publication April 19, 2016; accepted for publication April 20, 2016.
Patrick T. Roughneen, Abelardo DeAnda
openaire +3 more sources
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran+16 more
wiley +1 more source
Electrical Trees and Their Growth in Silicone Rubber at Various Voltage Frequencies
The insulation property at high voltage frequencies has become a tough challenge with the rapid development of high-voltage and high-frequency power electronics.
Yunxiao Zhang+4 more
doaj +1 more source
We demonstrate that thermocapillary forces may drive bubbles against liquid flow in 'anomalous' mixtures. Unlike 'ordinary' liquids, in which bubbles migrate towards higher temperatures, we have observed vapour bubbles migrating towards lower temperatures, therefore against the flow. This unusual behaviour may be explained by the temperature dependence
Martin E. R. Shanahan, Khellil Sefiane
openaire +3 more sources