Results 31 to 40 of about 177,849 (292)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang   +12 more
wiley   +1 more source

The architecture of Hungarian schools as a tool for forming the national identity. 1909-1927

open access: yesАрхитектон
School architecture in Hungary is seen as an important tool in the formation of this young nation. The Hungarian school was called upon to educate a “new citizen” and a “good Hungarian”, forming in children the image of their beloved Motherland.
Ivanova Alina P.
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

open access: yesAdvanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Old housing estates in the housing market of a post-socialist city : the case of Budapest

open access: yesGeographia Polonica
Housing estates were constructed by public authorities and private investors long before the era of large prefab housing estates. Their dwellings, like almost all flats, became privatised after 1989 in the postsocialist cities, thus they appeared in the ...
Balázs Szabó
doaj   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

open access: yesAdvanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang   +14 more
wiley   +1 more source

Budapest as a destination of migration: the view of transnational creative workers

open access: yesHungarian Geographical Bulletin, 2011
Creativity, knowledge and innovation are broadly recognised as the essential ingredients of economic success in the advanced capitalist world. Concerning further development of Europe it might be decisive how the metropolitan regions will be able to ...
Tamás Egedy, Zoltán Kovács
doaj  

Sometimes up, sometimes down on the seesaw: Experiencing industrial investment and disinvestment in Budapest’s Ganz-MÁVAG manufacturing site

open access: yesHungarian Geographical Bulletin
Drawing on Neil Smith’s “seesaw” metaphor of uneven development, this paper examines how historical cycles of industrial investment and disinvestment were/are lived, experienced, and narrated in Budapest’s former Ganz-MÁVAG manufacturing site ...
Márton Berki, Mirjam Sági
doaj   +1 more source

Budapest Past and Future [PDF]

open access: yes
The 150th anniversary of Budapest presents a prime opportunity to reflect on and identify the most critical issues and topics for research concerning our capital. The authors of this volume have embraced this task by delving into the history of Budapest,
unknown
core   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

open access: yesAdvanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu   +6 more
wiley   +1 more source

Who Are the Consumers of European Farmers' Markets? A Cross‐Country Analysis

open access: yesAgribusiness, EarlyView.
ABSTRACT With substantial growth in the number of farmers' markets (FMs) in developed countries, the number of consumers visiting FMs is also increasing. This study comparatively assesses the consumers of FMs in three European countries where FMs traditionally play a distinctive role in food supply chains.
Áron Török   +6 more
wiley   +1 more source

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